上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。
Ecteinascidin 770 (Synonyms: Ecteinascidine 770; Et-770) 纯度: ≥99.0%
Ecteinascidin 770 (ET-770)是具有抗癌活性的1,2,3,4-四氢异喹啉生物碱，抑制U373MG cells的IC50值为4.83 nM。
Ecteinascidin 770 Chemical Structure
CAS No. : 114899-80-8
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| 5 mg | ￥2800 | In-stock | |
| 10 mg | ￥4000 | In-stock | |
| 50 mg | ￥12000 | In-stock | |
| 100 mg | 询价 | ||
| 200 mg | 询价 |
* Please select Quantity before adding items.
Ecteinascidin 770 相关产品
•相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
- Apoptosis Compound Library
- Natural Product Library
- Anti-Cancer Compound Library
- Phenols Library
- Alkaloids Library
- Anti-Lung Cancer Compound Library
- Anti-Blood Cancer Compound Library
- Microbial Metabolite Library
| 生物活性 |
Ecteinascidin 770 (ET-770) is a 1,2,3,4-tetrahydroisoquinoline alkaloid with potent anti-cancer activities; inhibits U373MG cells with an IC50 of 4.83 nM. |
IC50 & Target |
IC50: 4.83 nM (U373MG cell)[1]; 0.6 nM (HCT116 cell), 2.4 nM (QG56 cell), 0.81 nM (DU145)[2] |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 体外研究 (In Vitro) |
Ecteinascidin 770 induces apoptosis of U373MG cells. The IC50 concentration of ecteinascidin 770 for killing U373MG glioblastoma cells in culture by using the MTT assay is 4.83 nM by a 72 hour-treatment[1]. The IC50 values against human cell lines HCT116, QG56, and DU145 are 0.6, 2.4, and 0.81 nM, respectively[2]. ET-770 is shown to enhance anoikis response of human lung cancer H23 cells in a dose-dependent manner. Ecteinascidin 770 sensitizes the cells by activating the p53 protein, which in turn down-regulates anti-apoptotic myeloid cell leukemia sequence-1 (MCL1) and up-regulates BCL2-associated X protein (BAX) proteins. However, B-cell lymphoma-2 (BCL2) proteins are not significantly affected by Ecteinascidin 770. The anoikis sensitization of ET-770 is observed in H460 lung cancer cells[3]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||||||
| 分子量 |
770.85 |
||||||||||||||||
| Formula |
C40H42N4O10S |
||||||||||||||||
| CAS 号 |
114899-80-8 |
||||||||||||||||
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||||||
| 储存方式 |
-20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
||||||||||||||||
| 溶解性数据 |
In Vitro:
DMSO : 50 mg/mL (64.86 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂： ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
|
||||||||||||||||
| 参考文献 |
|
| Cell Assay [3] |
Ecteinascidin 770 is dissolved in DMSO and diluted with appropriate medium. H23 and H460 cells are seeded into 96-well plates at 1×105 cell/mL for 24 h and then treated with different concentrations of ecteinascidin 770 for 24 h. Cells are then incubated with 20 μM of XTT reagent for a further 4 h at 37°C. The intensity of the formazan product is measured at 450 nm using a microplate reader. The cell viability is calculated from the optical density (OD) ratio of treated to non-treated control cells and is presented as a percentage to that of the non-treated controls[3]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
|---|---|
| 参考文献 |
|
所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务
![(Cys(Et)2·7)-α-CGRP (human) 编码 [196413-73-7]](http://www.fluoroprobe.com/wp-content/uploads/2022/10/20221006_633e5b14ca71b.png)
![(Cys(Et)2·7)-α-CGRP (human) 编码 [196413-73-7]](http://www.fluoroprobe.com/wp-content/uploads/2022/10/20221006_633e5b15297f7.jpg)
![(Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytoc 编码 [90779-69-4]](http://www.fluoroprobe.com/wp-content/uploads/2022/10/20221006_633e5a243af57.png)
![(Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytoc 编码 [90779-69-4]](http://www.fluoroprobe.com/wp-content/uploads/2022/10/20221006_633e5a2499c1f.jpg)
