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FR901464

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

FR901464  纯度: 99.79%

FR901464 是一种有效的剪切体 (spliceosome) 抑制剂，具有显著的抗肿瘤和抗癌作用。

FR901464

FR901464 Chemical Structure

CAS No. : 146478-72-0

规格 价格 是否有货 数量
1 mg ￥4000 In-stock
5 mg ￥12000 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

FR901464 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects[1].

体外研究
(In Vitro)

FR901464 (10-20 ng/ml; 6-24 hours) inhibits the growth of murine solid tumors, Colon 38 carcinoma and Meth A fibrosarcoma. FR901464 induces characteristic G1 and G2/M phase arrest in the cell cycle and internucleosomal degradation of genomic DNA with the same kinetics as activation of SV40 promoter-dependent cellular transcription in M-8 tumor cells[1].
FR901464 (1-10 ng/ml; 16 hours) suppresses the transcription of some inducible endogenous genes but not house keeping genes in M-8 cells[1].
FR901464 exhibits potent anticancer activity. It shows enhancement of activity of a promoter of the SV40 DNA tumor virus at 10 nM concentration in M-8 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

507.62

Formula

C27H41NO8
CAS 号

146478-72-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (197.00 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9700 mL 9.8499 mL 19.6998 mL
5 mM 0.3940 mL 1.9700 mL 3.9400 mL
10 mM 0.1970 mL 0.9850 mL 1.9700 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.92 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.92 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.92 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.92 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. J Antibiot (Tokyo). 1996 Dec;49(12):1204-11.

    [2]. Arun K Ghosh, et al. Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives. J Org Chem. 2014 Jun 20;79(12):5697-709.

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三-O-苄基FR 900098

发表于由

三-O-苄基FR 900098

受保护的抗生素FR 900098

有货

三-O-苄基FR 900098

CAS编号 1003599-68-5 | 品牌：Jinpan
Tri-O-benzyl FR 900098

MSDS

质检证书(CoA)

相似产品

  • 分子式 C₂₆H₃₀NO₅P
  • 分子量467.49
  • PubChem编号 71752687

货号 (SKU) 包装规格 是否现货 价格 数量
T351533-25mg 25mg 期货 三-O-苄基FR 900098  

基本信息

产品名称 三-O-苄基FR 900098
英文名称 Tri-O-benzyl FR 900098
英文别名 Tri-O-benzyl Antibiotic FR 900098
运输条件 常规运输

一般描述

PTri-O-苄基FR 900098是一种受保护的抗生素FR 900098。

PTri-O-benzyl FR 900098 is a protected Antibiotic FR 900098.

相关属性

CAS编号 1003599-68-5
分子量 467.49
分子式 C₂₆H₃₀NO₅P
品牌 Jinpan
Smiles CC(=O)N(CCCP(=O)(OCC1=CC=CC=C1)OCC2=CC=CC=C2)OCC3=CC=CC=C3
PubChem CID 71752687

FR 900098单钠盐

发表于由

FR 900098单钠盐

独特的膦酸天然产物类别的成员
98%

有货

FR 900098单钠盐

CAS编号 66508-32-5 | 品牌：Jinpan
FR 900098 Monosodium Salt

MSDS

质检证书(CoA)

相似产品

  • 分子式 C₅H₁₁NNaO₅P
  • 分子量219.11
  • PubChem编号 162204

货号 (SKU) 包装规格 是否现货 价格 数量
F342775-10mg 10mg 期货 FR 900098单钠盐  

基本信息

产品名称 FR 900098单钠盐
英文名称 FR 900098 Monosodium Salt
规格或纯度 98%
运输条件 超低温冰袋运输

一般描述

FR 900098单钠盐是一类独特的膦酸天然产物，可抑制类异戊二烯生物合成的非甲羟戊酸途径。

FR 900098 Monosodium Salt is a member of a unique class of phosphonic acid natural products that inhibit the nonmevalonate pathway for isoprenoid biosynthesis.

相关属性

CAS编号 66508-32-5
熔点 184-186°C (lit.)
储存温度 -20°C储存
分子量 219.11
分子式 C₅H₁₁NNaO₅P
品牌 Jinpan
Smiles CC(=O)N(CCCP(=O)(O)O)O
PubChem CID 162204

FR 180204

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

FR 180204  纯度: 99.47%

FR 180204 是一种 ATP 竞争性的选择性 ERK 抑制剂，对 ERK1 和 ERK2 的 Ki 值分别为 0.31 μM 和 0.14 μM。IC50 值分别为0.51 μM 和0.33 μM。

FR 180204

FR 180204 Chemical Structure

CAS No. : 865362-74-9

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥968 In-stock
5 mg ￥880 In-stock
10 mg ￥1550 In-stock
50 mg ￥7280 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

FR 180204 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Immunology/Inflammation Compound Library
  • Kinase Inhibitor Library
  • MAPK Compound Library
  • Stem Cell Signaling Compound Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Reprogramming Compound Library
  • Oxygen Sensing Compound Library
  • Glutamine Metabolism Compound Library
  • Anti-Pancreatic Cancer Compound Library
  • Anti-Obesity Compound Library
  • Angiogenesis Related Compound Library
  • Anti-Liver Cancer Compound Library
  • Anti-Colorectal Cancer Compound Library

生物活性

FR 180204 is an ATP-competitive and selective ERK inhibitor. FR 180204 inhibits ERK1 and ERK2 with IC50s of 0.51 μM (Ki=0.31 μM) and 0.33 μM (Ki=0.14 μM), respectively[1].

IC50 & Target[1]

ERK1

0.31 μM (Ki)

ERK2

0.14 μM (Ki)

ERK2

0.33 μM (IC50)

ERK1

0.51 μM (IC50)

体外研究
(In Vitro)

In AP-1-transfected cells, FR180204 dose-dependently inhibits AP-1 transactivation with IC50 of 3.1 μM[1]. FR 180204 inhibits spontaneous mesothelioma cell growth[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

FR180204 (100 mg/kg, i.p., b.i.d.) significantly decreases the severity of symptoms and body weight loss in collagen-induced arthritis mice[2]. In a mouse model of dengue virus (DENV) infection, FR180204 limits hepatocyte apoptosis, reduces DENV-induced liver injury, and improves clinical parameters[4].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

327.34

Formula

C18H13N7
CAS 号

865362-74-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 50 mg/mL (152.75 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0549 mL 15.2746 mL 30.5493 mL
5 mM 0.6110 mL 3.0549 mL 6.1099 mL
10 mM 0.3055 mL 1.5275 mL 3.0549 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.64 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (7.64 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.64 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (7.64 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Ohori M, et al. Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex. Biochem Biophys Res Commun. 2005 Oct 14;336(1):357-63.

    [2]. Ohori M, et al. FR180204, a novel and selective inhibitor of extracellular signal-regulated kinase, ameliorates collagen-induced arthritis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2007 Jan;374(4):311-6.

    [3]. Honda M, et al. Mesothelioma cell proliferation through autocrine activation of PDGF-ββ receptor. Cell Physiol Biochem. 2012;29(5-6):667-74

    [4]. Sreekanth GP, et al. Role of ERK1/2 signaling in dengue virus-induced liver injury. Virus Res. 2014 Aug 8;188:15-26
Kinase Assay
[1]

Nunc-Immuno MaxiSorp plates are coated with 20 μg/mL MBP solution in phosphate-buffered saline (PBS). After washing with PBS containing 0.05% Tween 20 (T-PBS), blocking buffer (T-PBS containing 3% BSA) is added to each well and the plates are incubated for 10 min at room temperature. After washing with T-PBS, chemical compounds, ATP and recombinant ERK2 diluted in assay dilution buffer (20 mM Mops, pH 7.2, 25 mM β-glycerol phosphate, 5 mM EGTA, 1 mM sodium orthovanadate, 1 mM dithiothreitol, and 50 μg/mL BSA) and are added to each well. Vehicle groups (containing 0.1% DMSO) and kinase-withdrawal groups are used for the control and basal determinations. After incubation for 1 h at room temperature, plates are washed twice with T-PBS. Anti-phospho MBP antibody (0.2 μg/mL) is added to each well, and the plates are incubated for 1 h at room temperature. After washing, anti-mouse HRP-conjugated polyclonal antibodies are added and the plates are incubated for 30 min.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[2]

In brief, mice are randomized and grouped by body weight immediately before treatment. Bovine CII is dissolved in 0.1mol/Lacetic acid at the concentration of 10 mg/mL and then emulsified in an equal volume of Freund’s complete adjuvant H37Rv. Apart from a naive group, each mouse is immunized with 25 μL of the CII emulsion into the tail base, followed by a boost injection 3 weeks after primary injection (day 0). FR180204 and methylprednisolone are ground and suspended in 0.1% methylcellulose solution to a volume of 5 mL/kg. Drugs are given by twice daily intraperitoneal injection from days 0 to 12 in accordance with pharmacokinetic studies with superior area under the curve and Cmax values of i.p. versus s.c. or p.o. administration. The initial administration is 30 min before the boost CII injection. The clinical score of arthritis is obtained by summing the visual severity grade of each limb, scored as follows: 0, no arthritis; 1, one swollen digit; 2, two or more swollen digits or swelling of the entire paw without ankylosis; 3, gross swelling with ankylosis of the paw. Body weight is measured on day 12.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Ohori M, et al. Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex. Biochem Biophys Res Commun. 2005 Oct 14;336(1):357-63.

    [2]. Ohori M, et al. FR180204, a novel and selective inhibitor of extracellular signal-regulated kinase, ameliorates collagen-induced arthritis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2007 Jan;374(4):311-6.

    [3]. Honda M, et al. Mesothelioma cell proliferation through autocrine activation of PDGF-ββ receptor. Cell Physiol Biochem. 2012;29(5-6):667-74

    [4]. Sreekanth GP, et al. Role of ERK1/2 signaling in dengue virus-induced liver injury. Virus Res. 2014 Aug 8;188:15-26

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

(6R)-FR054

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

(6R)-FR054  纯度: ≥98.0%

(6R)-FR054 是 FR054 的一个低活性异构体。

(6R)-FR054

(6R)-FR054 Chemical Structure

CAS No. : 10378-06-0

规格 价格 是否有货 数量
5 mg ￥3800 In-stock
10 mg ￥6000 In-stock
25 mg ￥11500 In-stock
50 mg 询价
100 mg 询价

* Please select Quantity before adding items.

(6R)-FR054 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Anti-Cancer Compound Library

生物活性

(6R)-FR054 is a less active isomer of FR054.

分子量

329.30

Formula

C14H19NO8
CAS 号

10378-06-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (303.67 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0367 mL 15.1837 mL 30.3674 mL
5 mM 0.6073 mL 3.0367 mL 6.0735 mL
10 mM 0.3037 mL 1.5184 mL 3.0367 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.59 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (7.59 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.59 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (7.59 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.59 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (7.59 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Francesca Ricciardiello, et al. Inhibition of the Hexosamine Biosynthetic Pathway by Targeting PGM3 Causes Breast Cancer Growth Arrest and Apoptosis. Cell Death Dis. 2018 Mar 7;9(3):377.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

德国CMVC离心机CMVC FR

发表于由

德国CMVC离心机CMVC FR

  • 品牌 CMVC|CMVC
  • 型号 CMVC FR
  • 货号 EY0109
  • 商品详情

    产品详情

    ◎ 德国制造

    ◎ 微处理器控制

    ◎ 可永久性安装在滚轴上或从滚轴上拆除

    ◎ 无需维修，无刷感应式驱动

    ◎ 不锈钢腔室,外加额外的内部保护环

    ◎ 超速检测,不平衡检测和断电

    ◎ 彩色大屏液晶显示当前和预设数值,包括速度、重力、时间和温度(只有在 CH-FR 冷冻模式下显示温度)

    技术参数：

    德国CMVC离心机CMVC FR

    德国CMVC离心机CMVC FR

    • FR054

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    FR054  纯度: ≥95.0%

    FR054 是 HBO 酶 PGM3 的抑制剂，具有明显的抗乳腺癌活性。

    FR054

    FR054 Chemical Structure

    CAS No. : 35954-65-5

    规格 价格 是否有货 数量
    5 mg ￥500 In-stock
    10 mg ￥750 In-stock
    50 mg ￥1600 In-stock
    100 mg ￥2500 In-stock
    200 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    FR054 相关产品

    •相关化合物库:

    • Bioactive Compound Library Plus
    • Anti-Cancer Compound Library
    • Endoplasmic Reticulum Stress Compound Library
    • Anti-Breast Cancer Compound Library

    生物活性

    FR054 is an inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect[1].

    体外研究
    (In Vitro)

    FR054 (0.5-1 mM, 24-48 h) induces an early proliferation arrest followed by a marked cell death increase in breast cancer cells and induces apoptosis. The effect of FR054 occurs through PGM3 inhibition instead of other off-target effects[1].
    FR054 (250 μM, 24 h) treatment efficiently affects both N- and O-glycosylation levels in MDA-MB-231 cells[1].
    FR054 induces endoplasmic reticulum (ER) stress and a ROS-dependent apoptotic cell death[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: MDA-MB-231 cells.
    Concentration: 0.5-1 mM.
    Incubation Time: 48 h.
    Result: Reduced viability and a significant increase of the apoptosis as compared to the control clone.

    体内研究
    (In Vivo)

    FR054 (1000 mg/kg, ip) suppresses cancer growth in MDA-MB-231 xenograft mice[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Mice were subcutaneously injected with MDA-MB-231 cells[1].
    Dosage: 1000 mg/kg.
    Administration: IP, single or fractionated dose (twice a day 500 mg/kg/dose).
    Result: Appears to have an in vivo antitumor efficacy that is higher when administered twice a day compared to single administration.

    分子量

    329.30

    Formula

    C14H19NO8
    CAS 号

    35954-65-5
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Pure form -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    In Vitro: 

    DMSO : 100 mg/mL (303.67 mM; Need ultrasonic)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 3.0367 mL 15.1837 mL 30.3674 mL
    5 mM 0.6073 mL 3.0367 mL 6.0735 mL
    10 mM 0.3037 mL 1.5184 mL 3.0367 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

    In Vivo:

    请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

    ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
    分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

    • 1.

      请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (7.59 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (7.59 mM，饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

      将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

    • 2.

      请依序添加每种溶剂： 10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (7.59 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (7.59 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

    *以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
    参考文献

    • [1]. Francesca Ricciardiello, et al. Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis. Cell Death Dis. 2018 Mar 7;9(3):377.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    FR901463

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    FR901463 

    FR901463 是一种有效的抗癌试剂 (anti-cancer agent)，可用于癌症研究。FR901463 增强 SV40 DNA 病毒启动子的转录活性。

    FR901463

    FR901463 Chemical Structure

    CAS No. : 146478-74-2

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    FR901463 is a potent anti-cancer agent and can be used for cancer research. FR901463 enhances the transcriptional activity of the promoter of SV40 DNA virus[1].

    分子量

    544.08

    Formula

    C27H42ClNO8
    CAS 号

    146478-74-2
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1996 Dec;49(12):1196-203.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    FR901465

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    FR901465 

    FR901465 是一种有效的抗癌 (anti-cancer) 和抗肿瘤试剂。FR901465 可用于癌症研究。

    FR901465

    FR901465 Chemical Structure

    CAS No. : 146478-73-1

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    FR901465 is a potent anti-cancer and anti-tumor agent. FR901465 can be used for cancer research[1].

    体外研究
    (In Vitro)

    FR901465 prolongs the life of mice bearing murine ascitic tumor P388 leukemia (T/C values 127% for FR901465 in mice bearing murine ascitic tumors[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    523.62

    Formula

    C27H41NO9
    CAS 号

    146478-73-1
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. J Antibiot (Tokyo). 1996 Dec;49(12):1204-11.

      [2]. H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. III. Structures of FR901463, FR901464 and FR901465. J Antibiot (Tokyo). 1997 Jan;50(1):96-9.

      [3]. Ratnakar N. Asolkar, et al. Discovery and Development of Natural Products for Pest Management. RETURN TO BOOKPREVCHAPTERNEXT

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    FR901463

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    FR901463 

    FR901463 是一种有效的抗癌试剂 (anti-cancer agent)，可用于癌症研究。FR901463 增强 SV40 DNA 病毒启动子的转录活性。

    FR901463

    FR901463 Chemical Structure

    CAS No. : 146478-74-2

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    FR901463 is a potent anti-cancer agent and can be used for cancer research. FR901463 enhances the transcriptional activity of the promoter of SV40 DNA virus[1].

    分子量

    544.08

    Formula

    C27H42ClNO8
    CAS 号

    146478-74-2
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1996 Dec;49(12):1196-203.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    FR901463

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    FR901463 

    FR901463 是一种有效的抗癌试剂 (anti-cancer agent)，可用于癌症研究。FR901463 增强 SV40 DNA 病毒启动子的转录活性。

    FR901463

    FR901463 Chemical Structure

    CAS No. : 146478-74-2

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    FR901463 is a potent anti-cancer agent and can be used for cancer research. FR901463 enhances the transcriptional activity of the promoter of SV40 DNA virus[1].

    分子量

    544.08

    Formula

    C27H42ClNO8
    CAS 号

    146478-74-2
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1996 Dec;49(12):1196-203.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    FR901465

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    FR901465 

    FR901465 是一种有效的抗癌 (anti-cancer) 和抗肿瘤试剂。FR901465 可用于癌症研究。

    FR901465

    FR901465 Chemical Structure

    CAS No. : 146478-73-1

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    FR901465 is a potent anti-cancer and anti-tumor agent. FR901465 can be used for cancer research[1].

    体外研究
    (In Vitro)

    FR901465 prolongs the life of mice bearing murine ascitic tumor P388 leukemia (T/C values 127% for FR901465 in mice bearing murine ascitic tumors[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    523.62

    Formula

    C27H41NO9
    CAS 号

    146478-73-1
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. J Antibiot (Tokyo). 1996 Dec;49(12):1204-11.

      [2]. H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. III. Structures of FR901463, FR901464 and FR901465. J Antibiot (Tokyo). 1997 Jan;50(1):96-9.

      [3]. Ratnakar N. Asolkar, et al. Discovery and Development of Natural Products for Pest Management. RETURN TO BOOKPREVCHAPTERNEXT

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    FR901465

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    FR901465 

    FR901465 是一种有效的抗癌 (anti-cancer) 和抗肿瘤试剂。FR901465 可用于癌症研究。

    FR901465

    FR901465 Chemical Structure

    CAS No. : 146478-73-1

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    FR901465 is a potent anti-cancer and anti-tumor agent. FR901465 can be used for cancer research[1].

    体外研究
    (In Vitro)

    FR901465 prolongs the life of mice bearing murine ascitic tumor P388 leukemia (T/C values 127% for FR901465 in mice bearing murine ascitic tumors[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    523.62

    Formula

    C27H41NO9
    CAS 号

    146478-73-1
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. J Antibiot (Tokyo). 1996 Dec;49(12):1204-11.

      [2]. H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. III. Structures of FR901463, FR901464 and FR901465. J Antibiot (Tokyo). 1997 Jan;50(1):96-9.

      [3]. Ratnakar N. Asolkar, et al. Discovery and Development of Natural Products for Pest Management. RETURN TO BOOKPREVCHAPTERNEXT

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务