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FW1256

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

FW1256  纯度: ≥98.0%

FW1256 是一种苯基类似物，也是一种缓释硫化氢 (H2S) 供体。FW1256 抑制 NF-κB 活性，并可诱导细胞凋亡 (apoptosis)，具有有效的抗炎作用，并可用于癌症和心血管疾病的研究。

FW1256

FW1256 Chemical Structure

CAS No. : 117089-08-4

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥3850 In-stock
5 mg ￥3500 In-stock
10 mg ￥6500 In-stock
50 mg ￥22500 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

FW1256 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Immunology/Inflammation Compound Library
  • NF-κB Signaling Compound Library
  • Stem Cell Signaling Compound Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Antioxidants Compound Library
  • Differentiation Inducing Compound Library
  • Oxygen Sensing Compound Library
  • Anti-Cardiovascular Disease Compound Library
  • Pyroptosis Compound Library
  • Anti-Breast Cancer Compound Library
  • Anti-Pancreatic Cancer Compound Library
  • Anti-Blood Cancer Compound Library
  • Anti-Obesity Compound Library
  • Transcription Factor Targeted Library
  • Anti-Liver Cancer Compound Library

生物活性

FW1256 is a phenyl analogue and a slow-releasing hydrogen sulfide (H2S) donor. FW1256 inhibits NF-κB activity and induces cell apoptosis. FW1256 exerts potent anti-inflammatory effects and has the potential for cancer and cardiovascular disease treatment[1][2].

体外研究
(In Vitro)

FW1256 (200 µM; 24.5 hours; AW264.7 cells) treatment significantly reduces IL-1β, COX-2 and iNOS mRNA and protein in LPS-stimulated RAW264.7 macrophages[1].
FW1256 (200 µM; 24.5 hours; AW264.7 cells) treatment significantly reduces IL-1β, COX-2 and iNOS PROTE and protein in LPS-stimulated RAW264.7 macrophages[1].
FW1256 concentration dependently decreases TNF-α (IC50 of 61.2 µM), IL-6 (IC50 of 11.7 µM), PGE2 (IC50 of 25.5 µM) and NO (IC50 of 34.6 µM) generation in LPS-stimulated RAW264.7 macrophages and bone marrow-derived macrophages (BMDMs) (IC50s of 414.9 µM, 300.2 µM, 4 µM and 9.5 µM for TNF-α, IL-6, PGE2 and NO, respectively) [1].
FW1256 decreases NF-κB activation as evidenced by reduced cytosolic phospho-IκBα levels and reduces nuclear p65 levels in LPS-stimulated RAW264.7 macrophages treated with FW1256[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: RAW264.7 cells
Concentration: 200 µM
Incubation Time: 24.5 hours
Result: Significantly reduced IL-1β, COX-2 and iNOS mRNA in LPS-stimulated RAW264.7 macrophages..

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 200 µM
Incubation Time: 24.5 hours
Result: Significantly reduced IL-1β, COX-2 and iNOS proteinin LPS-stimulated RAW264.7 macrophages..

体内研究
(In Vivo)

FW1256 (100 mg/kg; intraperitoneal injection; male C57BL/6 mice) treatment reduces IL-1β, TNFα, nitrate/nitrite and PGE2 levels in LPS-treated mice[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (20-25 g, 6-10 weeks) injected with E. coli lipopolysaccharide (LPS)[1]
Dosage: 100 mg/kg
Administration: Intraperitoneal injection
Result: Reduced IL-1β, TNFα, nitrate/nitrite and PGE2 levels in LPS-treated mice.

分子量

247.25

Formula

C12H10NOPS
CAS 号

117089-08-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 250 mg/mL (1011.12 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.0445 mL 20.2224 mL 40.4449 mL
5 mM 0.8089 mL 4.0445 mL 8.0890 mL
10 mM 0.4044 mL 2.0222 mL 4.0445 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Huang CW, et al. A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and in vivo. Pharmacol Res. 2016 Nov;113(Pt A):533-546.

    [2]. Feng W, et al. Discovery of New H2S Releasing Phosphordithioates and 2,3-Dihydro-2-phenyl-2-sulfanylenebenzo[d][1,3,2]oxazaphospholes with Improved Antiproliferative Activity. J Med Chem. 2015 Aug 27;58(16):6456-80.

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中科美菱 -40℃超低温冷冻储存箱（DW-FW251）

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中科美菱 -40℃超低温冷冻储存箱（DW-FW251）

中科美菱 -40℃超低温冷冻储存箱（DW-FW251）

  • 商品品牌： 中科美菱
    商品编号：DW-FW251
  • 商品价格： 请与我们联系

    • 中科美菱 -40℃超低温冷冻储存箱（DW-FW251）-中科美菱-DW-FW251

    • 产品类型:低温冰箱
    • 温度 :-40℃
    • 容积:201～300L
    • 外观形状 :卧式
    • 品牌属性:国产
    实验室常用设备|||实验箱体|||低温冰箱|||中科美菱-40℃超低温冷冻储存箱（DW-FW251）
    中科美菱/国产/卧式/医用冷藏箱/医用低温箱/-40℃低温冰箱/-40℃医用冰箱

    中科美菱 -40℃超低温冷冻储存箱（DW-FW251）

    功能介绍

    • 控温方式：高精度微电脑温度控制系统；
    • 采用微电脑精确控制器，温度在-10～-40℃范围内自由设定，数码温度显示
    • 完善的声光报警功能，具有高温报警、低温报警、传感器故障报警等多种报警功能
    • 开机延时、停机间隔等保护功能，确保运行可靠；
    • 压缩机：采用国际名牌高效压缩机，节能静音，无氟环保制冷剂
    • 风扇电机：采用名牌风扇电机

    商品属性

    • 产品类型:低温冰箱
    • 温度 :-40℃
    • 容积:201～300L
    • 外观形状 :卧式
    • 品牌属性:国产
    商品属性
    商品名称 中科美菱 -40℃超低温冷冻储存箱（DW-FW251）-DW-FW251-中科美菱
    型号 DW-FW251
    类别 实验室常用设备|||实验箱体|||低温冰箱|||中科美菱-40℃超低温冷冻储存箱（DW-FW251）
    品牌 中科美菱
    品牌简介 中科美菱
    关键字 中科美菱/国产/卧式/医用冷藏箱/医用低温箱/-40℃低温冰箱/-40℃医用冰箱,温度,卧式,低温,超低温,微电脑,功能

    中科美菱 -40℃超低温冷冻储存箱（DW-FW251）

    中科美菱 -40℃超低温冷冻储存箱（DW-FW110）

    发表于由
    中科美菱 -40℃超低温冷冻储存箱（DW-FW110）

    中科美菱 -40℃超低温冷冻储存箱（DW-FW110）

  • 商品品牌： 中科美菱
    商品编号：DW-FW110
  • 商品价格： 请与我们联系

    • 中科美菱 -40℃超低温冷冻储存箱（DW-FW110）-中科美菱-DW-FW110

    • 产品类型:低温冰箱
    • 温度 :-40℃
    • 容积:101～200L
    • 外观形状 :卧式
    • 品牌属性:国产
    实验室常用设备|||实验箱体|||低温冰箱|||中科美菱-40℃超低温冷冻储存箱（DW-FW110）
    中科美菱/国产/立式/医用冷藏箱/医用低温箱/-40℃低温冰箱/-40℃医用冰箱

    中科美菱 -40℃超低温冷冻储存箱

    （DW-FW110）

    功能介绍

    • 控温方式：高精度微电脑温度控制系统；
    • 采用微电脑精确控制器，温度在-10～-40℃范围内自由设定，数码温度显示
    • 完善的声光报警功能，具有高温报警、低温报警、传感器故障报警等多种报警功能
    • 开机延时、停机间隔等保护功能，确保运行可靠；
    • 压缩机：采用国际名牌高效压缩机，节能静音，无氟环保制冷剂
    • 风扇电机：采用名牌风扇电机

    商品属性

    • 产品类型:低温冰箱
    • 温度 :-40℃
    • 容积:101～200L
    • 外观形状 :卧式
    • 品牌属性:国产
    商品属性
    商品名称 中科美菱 -40℃超低温冷冻储存箱（DW-FW110）-DW-FW110-中科美菱
    型号 DW-FW110
    类别 实验室常用设备|||实验箱体|||低温冰箱|||中科美菱-40℃超低温冷冻储存箱（DW-FW110）
    品牌 中科美菱
    品牌简介 中科美菱
    关键字 中科美菱/国产/立式/医用冷藏箱/医用低温箱/-40℃低温冰箱/-40℃医用冰箱,温度,低温,超低温,微电脑,卧式,功能

    中科美菱 -40℃超低温冷冻储存箱（DW-FW110）

    中科美菱 -40℃超低温冷冻储存箱（DW-FW351）

    发表于由
    中科美菱 -40℃超低温冷冻储存箱（DW-FW351）

    中科美菱 -40℃超低温冷冻储存箱（DW-FW351）

  • 商品品牌： 中科美菱
    商品编号：DW-FW351
  • 商品价格： 请与我们联系

    • 中科美菱 -40℃超低温冷冻储存箱（DW-FW351）-中科美菱-DW-FW351

    • 产品类型:低温冰箱
    • 温度 :-40℃
    • 容积:301～500L
    • 外观形状 :卧式
    • 品牌属性:国产
    实验室常用设备|||实验箱体|||低温冰箱|||中科美菱-40℃超低温冷冻储存箱（DW-FW351）
    中科美菱/国产/卧式/医用冷藏箱/医用低温箱/-40℃低温冰箱/-40℃医用冰箱

    中科美菱 -40℃超低温冷冻储存箱

    （DW-FW351）

    功能介绍

    • 控温方式：高精度微电脑温度控制系统；
    • 采用微电脑精确控制器，温度在-10～-40℃范围内自由设定，数码温度显示
    • 完善的声光报警功能，具有高温报警、低温报警、传感器故障报警等多种报警功能
    • 开机延时、停机间隔等保护功能，确保运行可靠；
    • 压缩机：采用国际名牌高效压缩机，节能静音，无氟环保制冷剂
    • 风扇电机：采用名牌风扇电机

    商品属性

    • 产品类型:低温冰箱
    • 温度 :-40℃
    • 容积:301～500L
    • 外观形状 :卧式
    • 品牌属性:国产
    商品属性
    商品名称 中科美菱 -40℃超低温冷冻储存箱（DW-FW351）-DW-FW351-中科美菱
    型号 DW-FW351
    类别 实验室常用设备|||实验箱体|||低温冰箱|||中科美菱-40℃超低温冷冻储存箱（DW-FW351）
    品牌 中科美菱
    品牌简介 中科美菱
    关键字 中科美菱/国产/卧式/医用冷藏箱/医用低温箱/-40℃低温冰箱/-40℃医用冰箱,温度,卧式,低温,超低温,微电脑,功能

    中科美菱 -40℃超低温冷冻储存箱（DW-FW351）

    德国弗鲁克电子搅拌器-主机,FW30

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    德国弗鲁克电子搅拌器-主机,FW30

  • 品牌 弗鲁克|FLUKO
  • 型号 FW30
  • 货号 13301
  • 商品详情

    设备简介

    强力机械式搅拌，具备转速及扭矩调节，自动扭矩补偿、恒定转速输出、转速显示等特点，结构可靠，性能优异，可连续运行数百小时。


    适用工艺

    适用于实验室多黏度体系的分散、搅拌等混合工艺。

    功率：120W

    电源：220V，50Hz

    搅拌量  (H₂O)：50-20000ml

    最大处理粘度：100000CP

    速度范围I级：60～500rpm/I级240～2000rpm

    转速显示：四位液晶显示

    搅拌轴最大转矩：150Ncm

    接触物料材质：SS316L

    过热保护有(70℃）

    标准搅拌桨配置四叶片螺旋搅拌桨

    允许环境温度：5-40℃

    允许相对湿度：80%

    搅拌桨固定方式 钻夹头

    钻夹头夹持直径范围：0.5-10mm

    工作架、底座标配

    工序类型：分批处理

    外形尺寸：375×198×728

    重量：~9kg

    包装：纸箱

    • Conglobatin(Synonyms: FW-04-806)

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Conglobatin (Synonyms: FW-04-806)

    Conglobatin (FW-04-806) 是一种从 Streptomyces conglobatus 培养物中分离得到的大环内酯双内酯。Conglobatin 是一种具有口服活性的 Hsp90 抑制剂，可以与 Hsp90 的 N 末端域结合，并破坏 Hsp90-Cdc37 复合物的形成。Conglobatin 可诱导人乳腺癌细胞和食道鳞状细胞癌细胞凋亡，并在体内表现出抗肿瘤活性。

    Conglobatin(Synonyms: FW-04-806)

    Conglobatin Chemical Structure

    CAS No. : 72263-05-9

    规格 价格 是否有货
    500 μg ￥2500 询问价格 & 货期
    1 mg ￥3800 询问价格 & 货期
    5 mg ￥14500 询问价格 & 货期

    * Please select Quantity before adding items.

    生物活性

    Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus. Conglobatin is an orally active Hsp90 inhibitor. Conglobatin can bind to the N-terminal domain of Hsp90 and disrupt Hsp90-Cdc37 complex formation. Conglobatin induces apoptosis in human breast cancer cells and esophageal squamous cell carcinoma cells, and exhibits antitumor activity in vivo[1][2][3].

    IC50 & Target[2]

    HSP90

     

    体外研究
    (In Vitro)

    Conglobatin (6.25-100 μM; 48 h) markedly inhibits the proliferation of SKBR3 and MCF-7 cells, with IC50s of 12.11 and 39.44 μM, respectively[2].
    Conglobatin inhibits cell proliferation in EC109, KYSE70, KYSE450, KYSE150, KYSE180, and KYSE510 cells, with IC50s of 16.43, 15.89, 10.94, 10.50, 10.28, and 9.31 μM, respectively[3].
    Conglobatin (10-40 μM; 24 h) displays obvious arrest of SKBR3 and MCF-7 cells in the G2/M phase. Conglobatin induces apoptosis through caspase-dependent pathways in SKBR3 and MCF-7 cells[2].
    Conglobatin (10-40 μM; 3-24 h) reduces Hsp90 client protein levels and induces proteasome-dependent degradation[2].
    Conglobatin binds to the N-terminal of Hsp90, does not affect ATP-binding capability of Hsp90, but inhibits Hsp90/Cdc37 chaperone/co-chaperone interactions[2].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Proliferation Assay[2]

    Cell Line: SKBR3 and MCF-7 cells
    Concentration: 6.25, 12.5, 25, 50, 100 μM
    Incubation Time: 48 hours
    Result: Inhibited the proliferation of SKBR3 and MCF-7 cells in a dose-dependent manner.

    Cell Cycle Analysis[2]

    Cell Line: SKBR3 and MCF-7 cells
    Concentration: 10, 20, 40 μM
    Incubation Time: 24 hours
    Result: Increased the G2/M cell population and decreased the population in the S and G0/G1 phases.

    Western Blot Analysis[2]

    Cell Line: SKBR3 and MCF-7 cells
    Concentration: 10, 20, 40 μM
    Incubation Time: 3, 6, 12, 24 hours
    Result: Decreased the levels of the client proteins HER2, p-HER2, Raf-1, Akt, and p-Akt in a dose and time-dependent manner in SKBR3 cells.
    Reduced the the levels of the client proteins Raf-1, Akt, and p-Akt in a dose and time-dependent manner in MCF-7 cells.

    体内研究
    (In Vivo)

    Conglobatin (50-200 mg/kg; i.g. q3d for 24 d) inhibits the tumor growth of SKBR3 and MCF-7 human breast cancer xenograft models in a dose-dependent manner[2].
    Conglobatin (4-8 mg/kg; i.p. daily for 21 days) inhibits tumor growth in EC109 and KYSE510 tumor xenograft models with low toxicity[3]

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: BALB/c (nu/nu) athymic mice with SKBR3 and MCF-7 tumor xenograft[2]
    Dosage: 50, 100, 200 mg/kg
    Administration: Oral gavage every 3 days for 24 days
    Result: Showed inhibition of tumor growth at a rate of 39.1%, 52.7%, and 67.5% in the SKBR3 cell line groups and 27.3%, 39.8%, 54.3% in the MCF-7 cell line groups at the three increasing doses, respectively.
    Was well tolerated.

    分子量

    498.61

    Formula

    C28H38N2O6
    CAS 号

    72263-05-9
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Westley JW, et, al. Conglobatin, a novel macrolide dilactone from Streptomyces conglobatus ATCC 31005. J Antibiot (Tokyo). 1979 Sep;32(9):874-7.

      [2]. Huang W, et, al. FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation. Mol Cancer. 2014 Jun 14;13:150.

      [3]. Li LY, et, al. Macrolide analog F806 suppresses esophageal squamous cell carcinoma (ESCC) by blocking β1 integrin activation. Oncotarget. 2015 Jun 30;6(18):15940-52.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    Conglobatin(Synonyms: FW-04-806)

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Conglobatin (Synonyms: FW-04-806)

    Conglobatin (FW-04-806) 是一种从 Streptomyces conglobatus 培养物中分离得到的大环内酯双内酯。Conglobatin 是一种具有口服活性的 Hsp90 抑制剂，可以与 Hsp90 的 N 末端域结合，并破坏 Hsp90-Cdc37 复合物的形成。Conglobatin 可诱导人乳腺癌细胞和食道鳞状细胞癌细胞凋亡，并在体内表现出抗肿瘤活性。

    Conglobatin(Synonyms: FW-04-806)

    Conglobatin Chemical Structure

    CAS No. : 72263-05-9

    规格 价格 是否有货
    500 μg ￥2500 询问价格 & 货期
    1 mg ￥3800 询问价格 & 货期
    5 mg ￥14500 询问价格 & 货期

    * Please select Quantity before adding items.

    生物活性

    Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus. Conglobatin is an orally active Hsp90 inhibitor. Conglobatin can bind to the N-terminal domain of Hsp90 and disrupt Hsp90-Cdc37 complex formation. Conglobatin induces apoptosis in human breast cancer cells and esophageal squamous cell carcinoma cells, and exhibits antitumor activity in vivo[1][2][3].

    IC50 & Target[2]

    HSP90

     

    体外研究
    (In Vitro)

    Conglobatin (6.25-100 μM; 48 h) markedly inhibits the proliferation of SKBR3 and MCF-7 cells, with IC50s of 12.11 and 39.44 μM, respectively[2].
    Conglobatin inhibits cell proliferation in EC109, KYSE70, KYSE450, KYSE150, KYSE180, and KYSE510 cells, with IC50s of 16.43, 15.89, 10.94, 10.50, 10.28, and 9.31 μM, respectively[3].
    Conglobatin (10-40 μM; 24 h) displays obvious arrest of SKBR3 and MCF-7 cells in the G2/M phase. Conglobatin induces apoptosis through caspase-dependent pathways in SKBR3 and MCF-7 cells[2].
    Conglobatin (10-40 μM; 3-24 h) reduces Hsp90 client protein levels and induces proteasome-dependent degradation[2].
    Conglobatin binds to the N-terminal of Hsp90, does not affect ATP-binding capability of Hsp90, but inhibits Hsp90/Cdc37 chaperone/co-chaperone interactions[2].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Proliferation Assay[2]

    Cell Line: SKBR3 and MCF-7 cells
    Concentration: 6.25, 12.5, 25, 50, 100 μM
    Incubation Time: 48 hours
    Result: Inhibited the proliferation of SKBR3 and MCF-7 cells in a dose-dependent manner.

    Cell Cycle Analysis[2]

    Cell Line: SKBR3 and MCF-7 cells
    Concentration: 10, 20, 40 μM
    Incubation Time: 24 hours
    Result: Increased the G2/M cell population and decreased the population in the S and G0/G1 phases.

    Western Blot Analysis[2]

    Cell Line: SKBR3 and MCF-7 cells
    Concentration: 10, 20, 40 μM
    Incubation Time: 3, 6, 12, 24 hours
    Result: Decreased the levels of the client proteins HER2, p-HER2, Raf-1, Akt, and p-Akt in a dose and time-dependent manner in SKBR3 cells.
    Reduced the the levels of the client proteins Raf-1, Akt, and p-Akt in a dose and time-dependent manner in MCF-7 cells.

    体内研究
    (In Vivo)

    Conglobatin (50-200 mg/kg; i.g. q3d for 24 d) inhibits the tumor growth of SKBR3 and MCF-7 human breast cancer xenograft models in a dose-dependent manner[2].
    Conglobatin (4-8 mg/kg; i.p. daily for 21 days) inhibits tumor growth in EC109 and KYSE510 tumor xenograft models with low toxicity[3]

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: BALB/c (nu/nu) athymic mice with SKBR3 and MCF-7 tumor xenograft[2]
    Dosage: 50, 100, 200 mg/kg
    Administration: Oral gavage every 3 days for 24 days
    Result: Showed inhibition of tumor growth at a rate of 39.1%, 52.7%, and 67.5% in the SKBR3 cell line groups and 27.3%, 39.8%, 54.3% in the MCF-7 cell line groups at the three increasing doses, respectively.
    Was well tolerated.

    分子量

    498.61

    Formula

    C28H38N2O6
    CAS 号

    72263-05-9
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Westley JW, et, al. Conglobatin, a novel macrolide dilactone from Streptomyces conglobatus ATCC 31005. J Antibiot (Tokyo). 1979 Sep;32(9):874-7.

      [2]. Huang W, et, al. FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation. Mol Cancer. 2014 Jun 14;13:150.

      [3]. Li LY, et, al. Macrolide analog F806 suppresses esophageal squamous cell carcinoma (ESCC) by blocking β1 integrin activation. Oncotarget. 2015 Jun 30;6(18):15940-52.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    Conglobatin(Synonyms: FW-04-806)

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Conglobatin (Synonyms: FW-04-806)

    Conglobatin (FW-04-806) 是一种从 Streptomyces conglobatus 培养物中分离得到的大环内酯双内酯。Conglobatin 是一种具有口服活性的 Hsp90 抑制剂，可以与 Hsp90 的 N 末端域结合，并破坏 Hsp90-Cdc37 复合物的形成。Conglobatin 可诱导人乳腺癌细胞和食道鳞状细胞癌细胞凋亡，并在体内表现出抗肿瘤活性。

    Conglobatin(Synonyms: FW-04-806)

    Conglobatin Chemical Structure

    CAS No. : 72263-05-9

    规格 价格 是否有货
    500 μg ￥2500 询问价格 & 货期
    1 mg ￥3800 询问价格 & 货期
    5 mg ￥14500 询问价格 & 货期

    * Please select Quantity before adding items.

    生物活性

    Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus. Conglobatin is an orally active Hsp90 inhibitor. Conglobatin can bind to the N-terminal domain of Hsp90 and disrupt Hsp90-Cdc37 complex formation. Conglobatin induces apoptosis in human breast cancer cells and esophageal squamous cell carcinoma cells, and exhibits antitumor activity in vivo[1][2][3].

    IC50 & Target[2]

    HSP90

     

    体外研究
    (In Vitro)

    Conglobatin (6.25-100 μM; 48 h) markedly inhibits the proliferation of SKBR3 and MCF-7 cells, with IC50s of 12.11 and 39.44 μM, respectively[2].
    Conglobatin inhibits cell proliferation in EC109, KYSE70, KYSE450, KYSE150, KYSE180, and KYSE510 cells, with IC50s of 16.43, 15.89, 10.94, 10.50, 10.28, and 9.31 μM, respectively[3].
    Conglobatin (10-40 μM; 24 h) displays obvious arrest of SKBR3 and MCF-7 cells in the G2/M phase. Conglobatin induces apoptosis through caspase-dependent pathways in SKBR3 and MCF-7 cells[2].
    Conglobatin (10-40 μM; 3-24 h) reduces Hsp90 client protein levels and induces proteasome-dependent degradation[2].
    Conglobatin binds to the N-terminal of Hsp90, does not affect ATP-binding capability of Hsp90, but inhibits Hsp90/Cdc37 chaperone/co-chaperone interactions[2].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Proliferation Assay[2]

    Cell Line: SKBR3 and MCF-7 cells
    Concentration: 6.25, 12.5, 25, 50, 100 μM
    Incubation Time: 48 hours
    Result: Inhibited the proliferation of SKBR3 and MCF-7 cells in a dose-dependent manner.

    Cell Cycle Analysis[2]

    Cell Line: SKBR3 and MCF-7 cells
    Concentration: 10, 20, 40 μM
    Incubation Time: 24 hours
    Result: Increased the G2/M cell population and decreased the population in the S and G0/G1 phases.

    Western Blot Analysis[2]

    Cell Line: SKBR3 and MCF-7 cells
    Concentration: 10, 20, 40 μM
    Incubation Time: 3, 6, 12, 24 hours
    Result: Decreased the levels of the client proteins HER2, p-HER2, Raf-1, Akt, and p-Akt in a dose and time-dependent manner in SKBR3 cells.
    Reduced the the levels of the client proteins Raf-1, Akt, and p-Akt in a dose and time-dependent manner in MCF-7 cells.

    体内研究
    (In Vivo)

    Conglobatin (50-200 mg/kg; i.g. q3d for 24 d) inhibits the tumor growth of SKBR3 and MCF-7 human breast cancer xenograft models in a dose-dependent manner[2].
    Conglobatin (4-8 mg/kg; i.p. daily for 21 days) inhibits tumor growth in EC109 and KYSE510 tumor xenograft models with low toxicity[3]

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: BALB/c (nu/nu) athymic mice with SKBR3 and MCF-7 tumor xenograft[2]
    Dosage: 50, 100, 200 mg/kg
    Administration: Oral gavage every 3 days for 24 days
    Result: Showed inhibition of tumor growth at a rate of 39.1%, 52.7%, and 67.5% in the SKBR3 cell line groups and 27.3%, 39.8%, 54.3% in the MCF-7 cell line groups at the three increasing doses, respectively.
    Was well tolerated.

    分子量

    498.61

    Formula

    C28H38N2O6
    CAS 号

    72263-05-9
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Westley JW, et, al. Conglobatin, a novel macrolide dilactone from Streptomyces conglobatus ATCC 31005. J Antibiot (Tokyo). 1979 Sep;32(9):874-7.

      [2]. Huang W, et, al. FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation. Mol Cancer. 2014 Jun 14;13:150.

      [3]. Li LY, et, al. Macrolide analog F806 suppresses esophageal squamous cell carcinoma (ESCC) by blocking β1 integrin activation. Oncotarget. 2015 Jun 30;6(18):15940-52.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    泰斯特FW177中草药粉碎机

    发表于由

    泰斯特FW177中草药粉碎机

  • 品牌 泰斯特|TAISITE
  • 型号 FW177
  • 商品详情

    产品介绍

    主要用于各中药店、大小医院、工矿企业、科研单位实验室可以对各种中草药、粮食、土壤、矿石、矿物质进行粉碎处理。

    产品特征

    1、本产品粉碎室采用优质不锈钢制作。

    2、选用风冷式高速电机，能快速粉碎各种中草药。

    3、清洁便利，操作简便、粉碎效果好。

     

    技术参数

    型 号
    Model

    投入量(g)

    电源电压(V)

    功率
    (W)

    转速
    (r/min)

    粉碎效果 目

    产品外形尺寸(mm)

    包装外形尺寸(mm)

    净重(kg)

    毛重
    (kg)

    FW135

    200

    220

    800

    24000

    60-200

    200×220×330

    250×250×400

    6.5

    7

    FW177

    400

    220

    1200

    24000

    60-200

    200×240×360

    250×250×430

    9.5

    10

    • 泰斯特FW135中草药粉碎机

    发表于由

    泰斯特FW135中草药粉碎机

  • 品牌 泰斯特|TAISITE
  • 型号 FW135
  • 商品详情

    产品介绍

    主要用于各中药店、大小医院、工矿企业、科研单位实验室可以对各种中草药、粮食、土壤、矿石、矿物质进行粉碎处理。

    产品特征

    1、本产品粉碎室采用优质不锈钢制作。

    2、选用风冷式高速电机，能快速粉碎各种中草药。

    3、清洁便利，操作简便、粉碎效果好。

     

    技术参数

    型 号
    Model

    投入量(g)

    电源电压(V)

    功率
    (W)

    转速
    (r/min)

    粉碎效果 目

    产品外形尺寸(mm)

    包装外形尺寸(mm)

    净重(kg)

    毛重
    (kg)

    FW135

    200

    220

    800

    24000

    60-200

    200×220×330

    250×250×400

    6.5

    7

    FW177

    400

    220

    1200

    24000

    60-200

    200×240×360

    250×250×430

    9.5

    10

    • 泰斯特FW100高速万能粉碎机

    发表于由

    泰斯特FW100高速万能粉碎机

  • 品牌 泰斯特|TAISITE
  • 型号 FW100
  • 商品详情

    产品介绍

    主要用于工业、农业、工矿、医药卫生、煤炭、地质等科研单位，可以对各种粮食、土壤、药物、砂石、矿质物进行粉碎处理。

    产品特征

    1、粉碎室采用全不锈钢制做。

    2、粉碎室上盖装有透明观察窗可以直接观察粉碎物的粉碎效果。

    3、本产品具有体积小、粉碎效率高、操作简单、造型美观、等特点。

     

    技术参数

    型 号
    Model

    电源电压

    (V)

    电机功率(w)

     

    转速(r/min)

    粉碎效果(目)

    产品外形尺寸(mm)
    圆×高 (R×H)

    包装外形尺寸(mm)

    整机重量(kg)
    t

    毛重 (kg)

    FW80

    220

    200

    10000

    60-200

    ф130×280

    300×160×180

    4±0.3

    4.5

    FW100

    220

    460

    24000

     

    ф140×290

    325×180×190

    3±0.3

    3.5

    • 泰斯特FW80高速万能粉碎机

    发表于由

    泰斯特FW80高速万能粉碎机

  • 品牌 泰斯特|TAISITE
  • 型号 FW80
  • 商品详情

    产品介绍

    主要用于工业、农业、工矿、医药卫生、煤炭、地质等科研单位，可以对各种粮食、土壤、药物、砂石、矿质物进行粉碎处理。

    产品特征

    1、粉碎室采用全不锈钢制做。

    2、粉碎室上盖装有透明观察窗可以直接观察粉碎物的粉碎效果。

    3、本产品具有体积小、粉碎效率高、操作简单、造型美观、等特点。

     

    技术参数

    型 号
    Model

    电源电压

    (V)

    电机功率(w)

     

    转速(r/min)

    粉碎效果(目)

    产品外形尺寸(mm)
    圆×高 (R×H)

    包装外形尺寸(mm)

    整机重量(kg)
    t

    毛重 (kg)

    FW80

    220

    200

    10000

    60-200

    ф130×280

    300×160×180

    4±0.3

    4.5

    FW100

    220

    460

    24000

     

    ф140×290

    325×180×190

    3±0.3

    3.5