hA2A/hCA XII modulator 1

发表于2024年11月8日由上海金畔生物科技有限公司

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

hA2A/hCA XII modulator 1

hA2A/hCA XII modulator 1 (compound 14) 是一种三唑并吡嗪，一种有效的 hA2A 腺苷受体 (hA_2AAR) 拮抗剂，对 hA_2AAR、hA₁AR、hA₃AR 的 K_i 分别为 6.4 nM、4.819 μM、>30 μM。hA2A/hCA XII modulator 1 是一种有效的人碳酸酐酶 XII (hCA XII) 抑制剂，对 hCA XII、hCA II、hCA IX 和 hCA I 的 K_i 分别为 6.2 nM、46 nM、466 nM、8.351 μM。hA2A/hCA XII modulator 1 具有用于癌症研究的潜力。

hA2A/hCA XII modulator 1 Chemical Structure

CAS No. : 2548963-55-7

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生物活性

hA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent hA_2A adenosine receptor (hA_2AAR) antagonist with K_is of 6.4 nM, 4.819 μM, >30 μM for hA_2AAR, hA₁AR, hA₃AR, respectively. hA2A/hCA XII modulator 1 is a potent human carbonic anhydrase XII (hCA XII) inhibitor with K_is of 6.2 nM, 46 nM, 466 nM, 8.351 μM for hCA XII, hCA II, hCA IX and hCA I, respectively. hA2A/hCA XII modulator 1 has the potential for cancer research^[1].

IC₅₀ & Target^[1]

hA_2AAR

6.4 nM (Ki)

hA₁AR

4.819 μM (Ki)

hA₃

>30 μM (Ki)

分子量

501.52

Formula

C₂₄H₁₉N₇O₄S

CAS 号

2548963-55-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Costanza Ceni, et al. Discovery of first-in-class multi-target adenosine A 2A receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents. Eur J Med Chem. 2020 Sep 1;201:112478.

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hCAII-IN-3

发表于2023年12月12日由上海金畔生物科技有限公司

hCAII-IN-3

hCAII-IN-3 (Compound 16) 是一种人碳酸酐酶 (hCA) 抑制剂，对 hCA I、hCA II、hCA IX 和 hCA XII 的 K_i 值分别为 403.8、5.1、10.2 和 5.2 nM。

hCAII-IN-3 Chemical Structure

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生物活性	hCAII-IN-3 (Compound 16) is a human carbonic anhydrase (hCA) inhibitor with K_i values of 403.8, 5.1, 10.2 and 5.2 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. hCA IX-IN-2 shows anticancer activity^[1].
IC₅₀ & Target	K_i: 5.1 nM (hCA II), 5.2 nM (hCA XII), 10.2 nM (hCA IX), 403.8 nM (hCA I)^[1]
分子量	347.43
Formula	C₁₇H₂₁N₃O₃S
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Elbadawi MM, et al. Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors. Eur J Med Chem. 2022 Apr 27;238:114412.

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hCA IX-IN-1

发表于2023年12月10日由上海金畔生物科技有限公司

hCA IX-IN-1

hCA IX-IN-1 (Compound 6f) 是一种人碳酸酐酶 (hCA) 抑制剂，对 hCA I、hCA II、hCA IX 和 hCA XII 的 K_i 值分别为 331.4、28.4、9.4 和 17.8 nM。

hCA IX-IN-1 Chemical Structure

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生物活性	hCA IX-IN-1 (Compound 6f) is a human carbonic anhydrase (hCA) inhibitor with K_i values of 331.4, 28.4, 9.4 and 17.8 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. hCA IX-IN-1 shows anticancer activity^[1].
IC₅₀ & Target	K_i: 9.4 nM (hCA IX), 17.8 nM (hCA XII), 28.4 nM (hCA II), 331.4 nM (hCA I)^[1]
分子量	354.42
Formula	C₁₉H₁₈N₂O₃S
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Elbadawi MM, et al. Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors. Eur J Med Chem. 2022 Apr 27;238:114412.

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hCAI/II-IN-1

发表于2023年12月10日由上海金畔生物科技有限公司

hCAI/II-IN-1

hCAI/II-IN-1 (Compound 3h) 是一种人碳酸酐酶 I 和 II (hCA I/II) 抑制剂，对 hCA I 和 hCA II 的 IC₅₀ 值分别为 0.047 µM 和 0.024 µM。

hCAI/II-IN-1 Chemical Structure

CAS No. : 2422028-82-6

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生物活性	hCAI/II-IN-1 (Compound 3h) is a human carbonic anhydrase I and II (hCA I/II) inhibitor with IC₅₀ values of 0.047 µM and 0.024 µM against hCA I and hCA II, respectively^[1].
IC₅₀ & Target	IC₅₀: 0.024 µM (hCA II), 0.047 µM (hCA I)^[1] K_i: 0.013 µM (hCA II), 0.032 µM (hCA I)^[1]
分子量	459.65
Formula	C₁₈H₂₉N₅O₃S₃
CAS 号	2422028-82-6
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Sağlık BN, et al. Synthesis, characterization and carbonic anhydrase I and II inhibitory evaluation of new sulfonamide derivatives bearing dithiocarbamate. Eur J Med Chem. 2020 Jul 15;198:112392.

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hCAII-IN-2

发表于2023年12月10日由上海金畔生物科技有限公司

hCAII-IN-2

hCAII-IN-2 (Compound 11f) 是一种胞质型人碳酸酐酶 (hCA) 抑制剂，对 hCA I、hCA II、hCA IX 和 hCA XII 的 K_i 分别为 261.4、3.8、19.6 和 45.2 nM

hCAII-IN-2 Chemical Structure

CAS No. : 2408599-78-8

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生物活性	hCAII-IN-2 (Compound 11f) is a cytosolic human carbonic anhydrase (hCA) inhibitor with K_i values of 261.4, 3.8, 19.6 and 45.2 nM against hCA I, hCA II, hCA IX and hCA XII, respectively^[1].
IC₅₀ & Target	K_i: 3.8 nM (hCA II), 19.6 nM (hCA IX), 45.2 nM (hCA XII), 261.4 nM (hCA I)^[1]
分子量	519.96
Formula	C₂₅H₁₈ClN₅O₄S
CAS 号	2408599-78-8
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Khalil OM, et al. Pyrrolo and pyrrolopyrimidine sulfonamides act as cytotoxic agents in hypoxia via inhibition of transmembrane carbonic anhydrases. Eur J Med Chem. 2020 Feb 15;188:112021.

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Carbonic anhydrase inhibitor 7

发表于2023年11月19日由上海金畔生物科技有限公司

Carbonic anhydrase inhibitor 7

Carbonic anhydrase inhibitor 7 (化合物 5b) 是一种有效的人碳酸酐酶 (hCA) 抑制剂，对 hCA IX，hCA II，hCA XII 和 hCA I 的 K_i 值分别为 6.5 nM, 7.1 nM, 72.1 nM, and 255.8 nM。

Carbonic anhydrase inhibitor 7 Chemical Structure

CAS No. : 546105-61-7

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生物活性	Carbonic anhydrase inhibitor 7 (compound 5b) is a potent inhibitor of human carbonic anhydrase (hCA), with K_is of 6.5 nM, 7.1 nM, 72.1 nM, and 255.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively^[1].
分子量	447.46
Formula	C₂₃H₁₇N₃O₅S
CAS 号	546105-61-7
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Swain B, et, al. Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases. Eur J Med Chem. 2022 Apr 15;234:114247.

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Carbonic anhydrase inhibitor 6

发表于2023年11月19日由上海金畔生物科技有限公司

Carbonic anhydrase inhibitor 6

Carbonic anhydrase inhibitor 6 (化合物 9b) 是一种有效的人碳酸酐酶 (hCA) 抑制剂，对 hCA IX，hCA II，hCA XII 和 hCA I 的 K_i 值分别为 9.7 nM, 35.2 nM, 88.5 nM, and 91.8 nM。

Carbonic anhydrase inhibitor 6 Chemical Structure

CAS No. : 1013213-84-7

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生物活性	Carbonic anhydrase inhibitor 6 (compound 9b) is a potent inhibitor of human carbonic anhydrase (hCA), with K_is of 9.7 nM, 35.2 nM, 88.5 nM, and 91.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively^[1].
分子量	491.56
Formula	C₂₆H₂₅N₃O₅S
CAS 号	1013213-84-7
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Swain B, et, al. Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases. Eur J Med Chem. 2022 Apr 15;234:114247.

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Carbonic anhydrase inhibitor 7

发表于2023年11月19日由上海金畔生物科技有限公司

Carbonic anhydrase inhibitor 7

Carbonic anhydrase inhibitor 7 Chemical Structure

CAS No. : 546105-61-7

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生物活性	Carbonic anhydrase inhibitor 7 (compound 5b) is a potent inhibitor of human carbonic anhydrase (hCA), with K_is of 6.5 nM, 7.1 nM, 72.1 nM, and 255.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively^[1].
分子量	447.46
Formula	C₂₃H₁₇N₃O₅S
CAS 号	546105-61-7
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Swain B, et, al. Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases. Eur J Med Chem. 2022 Apr 15;234:114247.

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Carbonic anhydrase inhibitor 7

发表于2023年11月19日由上海金畔生物科技有限公司

Carbonic anhydrase inhibitor 7

Carbonic anhydrase inhibitor 7 Chemical Structure

CAS No. : 546105-61-7

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生物活性	Carbonic anhydrase inhibitor 7 (compound 5b) is a potent inhibitor of human carbonic anhydrase (hCA), with K_is of 6.5 nM, 7.1 nM, 72.1 nM, and 255.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively^[1].
分子量	447.46
Formula	C₂₃H₁₇N₃O₅S
CAS 号	546105-61-7
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Swain B, et, al. Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases. Eur J Med Chem. 2022 Apr 15;234:114247.

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Carbonic anhydrase inhibitor 6

发表于2023年11月19日由上海金畔生物科技有限公司

Carbonic anhydrase inhibitor 6

Carbonic anhydrase inhibitor 6 Chemical Structure

CAS No. : 1013213-84-7

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生物活性	Carbonic anhydrase inhibitor 6 (compound 9b) is a potent inhibitor of human carbonic anhydrase (hCA), with K_is of 9.7 nM, 35.2 nM, 88.5 nM, and 91.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively^[1].
分子量	491.56
Formula	C₂₆H₂₅N₃O₅S
CAS 号	1013213-84-7
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Swain B, et, al. Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases. Eur J Med Chem. 2022 Apr 15;234:114247.

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Carbonic anhydrase inhibitor 6

发表于2023年11月19日由上海金畔生物科技有限公司

Carbonic anhydrase inhibitor 6

Carbonic anhydrase inhibitor 6 Chemical Structure

CAS No. : 1013213-84-7

规格		是否有货
100 mg		询价
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生物活性	Carbonic anhydrase inhibitor 6 (compound 9b) is a potent inhibitor of human carbonic anhydrase (hCA), with K_is of 9.7 nM, 35.2 nM, 88.5 nM, and 91.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively^[1].
分子量	491.56
Formula	C₂₆H₂₅N₃O₅S
CAS 号	1013213-84-7
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Swain B, et, al. Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases. Eur J Med Chem. 2022 Apr 15;234:114247.

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whatman (沃特曼)

英国沃特曼 Millipore PALL中国代理商金畔官网

标签归档：hca

hA2A/hCA XII modulator 1

hCAII-IN-3

hCA IX-IN-1

hCAI/II-IN-1

hCAII-IN-2

Carbonic anhydrase inhibitor 7

Carbonic anhydrase inhibitor 6

Carbonic anhydrase inhibitor 7

Carbonic anhydrase inhibitor 7

Carbonic anhydrase inhibitor 6

Carbonic anhydrase inhibitor 6

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