标签归档：hdm

Siremadlin(Synonyms: NVP-HDM201; HDM201)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Siremadlin (Synonyms: NVP-HDM201; HDM201) 纯度: 99.82%

Siremadlin (NVP-HDM201) 是口服有效的选择性 p53-MDM2 抑制剂。

Siremadlin(Synonyms: NVP-HDM201; HDM201)

Siremadlin Chemical Structure

CAS No. : 1448867-41-1

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2566 In-stock
1 mg ￥750 In-stock
5 mg ￥2100 In-stock
10 mg ￥3200 In-stock
50 mg ￥11000 In-stock
100 mg ￥17500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

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生物活性

Siremadlin (NVP-HDM201) is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor.

体外研究
(In Vitro)

Siremadlin (NVP-HDM201) disrupts both human and murine TP53- MDM2 interactions, with nanomolar cellular IC50 values, blocking TP53 degradation[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Siremadlin (NVP-HDM201) is an imidazolopyrrolidinone analogue, showing a very advantageous in vivo profile. NVP-HDM201 has recently entered Phase 1 clinical trials in cancer patients[2]. Constitutive PB mutagenesis in Arf−/− mice provides a collection of spontaneous tumors with characterized insertional genetic landscapes. Tumors are allografted in large cohorts of mice to assess the pharmacologic effects of Siremadlin (NVP-HDM201). Sixteen out of 21 allograft models are sensitive to Siremadlin (NVP-HDM201) but ultimately relapse under treatment. A comparison of tumors with acquired resistance to Siremadlin (NVP-HDM201) and untreated tumors identified 87 genes that are differentially and significantly targeted by the PB transposon[1]. Siremadlin (NVP-HDM201) administered either daily at a low dose or once at a high dose revealed a differentiated engagement of the p53 molecular response. In contrast to the daily low dose treatment regimen, the single high dose Siremadlin (NVP-HDM201) regimen results in a rapid and dramatic induction of p53-dependent PUMA expression and apoptosis. This is consistent with the finding that a single high dose Siremadlin (NVP-HDM201) treatment, administered orally or intravenously, results in a robust and sustained tumor regression. Overall, both daily and once every 3 weeks dosing regimen shows comparable long term efficacy in preclinical studies. The ongoing clinical trial is currently designed to compare both dosing regimens with regard to efficacy and tolerability[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

555.41

Formula

C26H24Cl2N6O4
CAS 号

1448867-41-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 56.75 mg/mL (102.18 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8005 mL 9.0024 mL 18.0047 mL
5 mM 0.3601 mL 1.8005 mL 3.6009 mL
10 mM 0.1800 mL 0.9002 mL 1.8005 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.50 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.50 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.50 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.50 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

  • 3.

    请依序添加每种溶剂： 5% DMSO    40% PEG300    5% Tween-80    50% saline

    Solubility: ≥ 2.5 mg/mL (4.50 mM); Clear solution

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Chapeau EA, et al. Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf-/- mouse model. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3151-3156.

    [2]. Furet P, et al. Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4837-41.

    [3]. Stéphane F, et al. Abstract 1224: Insights into the mechanism of action of NVP-HDM201, a differentiated and versatile Next-Generation small-molecule inhibitor of Mdm2, under evaluation in phase I clinical trials. Insights into the mechanism of action of NVP-HDM201, a differentiated and versatile Next-Generation small-molecule inhibitor of Mdm2, under evaluation in phase I clinical trials. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1224.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

常州国华恒温电热套HDM-2000

发表于由

常州国华恒温电热套HDM-2000

  • 品牌 国华|GUOHUA
  • 型号 HDM-2000
  • 商品详情

    调温电热套广泛适用于大中院校、石油、化工、医药、环保等行业的实验室的液体加热，它采用耐高温无碱玻璃纤维作绝缘材料，将镍铬材料的电阻丝密封在绝缘层内编织成半球形内热式加热器，具有加热面积大，升温快，无明火，加热均匀，安全节能等优点。

     

    使用说明：
    1、将装有试验样品的容器外部清洁干净后放入电热套中，并固定好。

    2、接通电源，合上电源开关，指示灯亮。

    3、将温度探头放入溶液内。

    4、根据机器调温刻度调节设定温度，此时机器根据设定温度自动加热或保温。

    5、工作完毕后切断电源，将调温旋钮置于最低温位置。

    6、清洁机器。

     

    技术参数

    型    号

    HDM-250

    HDM-500

    HDM-1000

    HDM-2000

    容    量

    250ML

    500ML

    1000ML

    2000ML

    加热功率

    200W

    400W

    800W

    1500W

    温控范围

    室温~200℃

    室温~200℃

    室温~200℃

    室温~200℃

    外形尺寸mm

    300×260×200

    380×280×200

    450×300×200

    450×350×200

     

    • 常州国华恒温电热套HDM-1000

    发表于由

    常州国华恒温电热套HDM-1000

  • 品牌 国华|GUOHUA
  • 型号 HDM-1000
  • 商品详情

    调温电热套广泛适用于大中院校、石油、化工、医药、环保等行业的实验室的液体加热，它采用耐高温无碱玻璃纤维作绝缘材料，将镍铬材料的电阻丝密封在绝缘层内编织成半球形内热式加热器，具有加热面积大，升温快，无明火，加热均匀，安全节能等优点。

     

    使用说明：
    1、将装有试验样品的容器外部清洁干净后放入电热套中，并固定好。

    2、接通电源，合上电源开关，指示灯亮。

    3、将温度探头放入溶液内。

    4、根据机器调温刻度调节设定温度，此时机器根据设定温度自动加热或保温。

    5、工作完毕后切断电源，将调温旋钮置于最低温位置。

    6、清洁机器。

     

    技术参数

    型    号

    HDM-250

    HDM-500

    HDM-1000

    HDM-2000

    容    量

    250ML

    500ML

    1000ML

    2000ML

    加热功率

    200W

    400W

    800W

    1500W

    温控范围

    室温~200℃

    室温~200℃

    室温~200℃

    室温~200℃

    外形尺寸mm

    300×260×200

    380×280×200

    450×300×200

    450×350×200

     

    • 常州国华恒温电热套HDM-500

    发表于由

    常州国华恒温电热套HDM-500

  • 品牌 国华|GUOHUA
  • 型号 HDM-500
  • 商品详情

    调温电热套广泛适用于大中院校、石油、化工、医药、环保等行业的实验室的液体加热，它采用耐高温无碱玻璃纤维作绝缘材料，将镍铬材料的电阻丝密封在绝缘层内编织成半球形内热式加热器，具有加热面积大，升温快，无明火，加热均匀，安全节能等优点。

     

    使用说明：
    1、将装有试验样品的容器外部清洁干净后放入电热套中，并固定好。

    2、接通电源，合上电源开关，指示灯亮。

    3、将温度探头放入溶液内。

    4、根据机器调温刻度调节设定温度，此时机器根据设定温度自动加热或保温。

    5、工作完毕后切断电源，将调温旋钮置于最低温位置。

    6、清洁机器。

     

    技术参数

    型    号

    HDM-250

    HDM-500

    HDM-1000

    HDM-2000

    容    量

    250ML

    500ML

    1000ML

    2000ML

    加热功率

    200W

    400W

    800W

    1500W

    温控范围

    室温~200℃

    室温~200℃

    室温~200℃

    室温~200℃

    外形尺寸mm

    300×260×200

    380×280×200

    450×300×200

    450×350×200

     

    • 常州国华恒温电热套HDM-250

    发表于由

    常州国华恒温电热套HDM-250

  • 品牌 国华|GUOHUA
  • 型号 HDM-250
  • 商品详情

    调温电热套广泛适用于大中院校、石油、化工、医药、环保等行业的实验室的液体加热，它采用耐高温无碱玻璃纤维作绝缘材料，将镍铬材料的电阻丝密封在绝缘层内编织成半球形内热式加热器，具有加热面积大，升温快，无明火，加热均匀，安全节能等优点。

     

    使用说明：
    1、将装有试验样品的容器外部清洁干净后放入电热套中，并固定好。

    2、接通电源，合上电源开关，指示灯亮。

    3、将温度探头放入溶液内。

    4、根据机器调温刻度调节设定温度，此时机器根据设定温度自动加热或保温。

    5、工作完毕后切断电源，将调温旋钮置于最低温位置。

    6、清洁机器。

     

    技术参数

    型    号

    HDM-250

    HDM-500

    HDM-1000

    HDM-2000

    容    量

    250ML

    500ML

    1000ML

    2000ML

    加热功率

    200W

    400W

    800W

    1500W

    温控范围

    室温~200℃

    室温~200℃

    室温~200℃

    室温~200℃

    外形尺寸mm

    300×260×200

    380×280×200

    450×300×200

    450×350×200

     

    • HLI373

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    HLI373 

    HLI373 是一种有效的 Hdm2 抑制剂。HLI373 抑制 Hdm2 泛素连接酶活性。HLI373 可有效诱导肿瘤细胞 (对 DNA 破坏剂敏感的) 凋亡 (apoptosis)。具有抗疟疾 (antimalarial) 活性。

    HLI373

    HLI373 Chemical Structure

    CAS No. : 502137-98-6

    规格 价格 是否有货
    5 mg ￥7500 询问价格 & 货期

    * Please select Quantity before adding items.

    生物活性

    HLI373 is an efficacious Hdm2 inhibitor. HLI373 inhibits the ubiquitin ligase activity of Hdm2. HLI373 is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents[1]. Antimalarial activity[2].

    IC50 & Target

    Hdm2[1]; Apoptosis[1]; Antimalarial[2]
    体外研究
    (In Vitro)

    HLI373 (3-15 μM; 15 hours) selectively kills tumor cells harboring wild type p53[1].
    HLI373 (10-50 μM) stabilizes cellular Hdm2 in a dose-dependent manner.
    HLI373 (3 μM) activates p53 transcription[1].
    HLI373 selectively inhibits auto-ubiquitylation of Hdm2[1].
    Co-transfection with plasmids encoding p53 and Hdm2 results in degradation of p53. Incubation with HLI373 (5-10 μM; 8 hours) blocks p53 degradation. HLI373 increases p53 and Hdm2 protein levels in cells[1].
    HLI 373 also shows lower IC50 values (below 6 μM) against both chloroquine-sensitive P. falciparum D6 strain (PfD6) and chloroquine-resistant P. falciparum W2 strain (PfW2) and exhibits early growth inhibition[2].
    HLI-373 is a MDM2 inhibitor interrupting its ubiquitin E3 ligase activity, could abolish the ubiquitylation of its substrate protein p53. HLI-373 targets the C-terminus functioning as an E3 ubiquitin ligase[3].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: Wild type p53 mouse embryo fibroblasts (MEFs), and p53-deficient MEFs
    Concentration: 3, 10, 15 μM
    Incubation Time: 15 hours
    Result: Increased cell death in wild type p53 MEFs in a dose-dependent manner, p53-deficient MEFs were relatively resistant.

    Western Blot Analysis[1]

    Cell Line: U2OS cells
    Concentration: 5, 10 μM
    Incubation Time: 8 hours
    Result: Blocked p53 degradation caused by co-transfection with plasmids encoding p53 and Hdm2.

    分子量

    341.41

    Formula

    C18H23N5O2
    CAS 号

    502137-98-6
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Jirouta Kitagaki, et al. Targeting Tumor Cells Expressing p53 With a Water-Soluble Inhibitor of Hdm2. Mol Cancer Ther. 2008 Aug;7(8):2445-54.

      [2]. Jagrati Jain, et al. Inhibitors of Ubiquitin E3 Ligase as Potential New Antimalarial Drug Leads. BMC Pharmacol Toxicol. 2017 Jun 2;18(1):40.

      [3]. Ying Chen, et al. MDM2 Promotes Epithelial-Mesenchymal Transition and Metastasis of Ovarian Cancer SKOV3 Cells. Br J Cancer. 2017 Oct 10;117(8):1192-1201.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    HLI373

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    HLI373 

    HLI373 是一种有效的 Hdm2 抑制剂。HLI373 抑制 Hdm2 泛素连接酶活性。HLI373 可有效诱导肿瘤细胞 (对 DNA 破坏剂敏感的) 凋亡 (apoptosis)。具有抗疟疾 (antimalarial) 活性。

    HLI373

    HLI373 Chemical Structure

    CAS No. : 502137-98-6

    规格 价格 是否有货
    5 mg ￥7500 询问价格 & 货期

    * Please select Quantity before adding items.

    生物活性

    HLI373 is an efficacious Hdm2 inhibitor. HLI373 inhibits the ubiquitin ligase activity of Hdm2. HLI373 is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents[1]. Antimalarial activity[2].

    IC50 & Target

    Hdm2[1]; Apoptosis[1]; Antimalarial[2]
    体外研究
    (In Vitro)

    HLI373 (3-15 μM; 15 hours) selectively kills tumor cells harboring wild type p53[1].
    HLI373 (10-50 μM) stabilizes cellular Hdm2 in a dose-dependent manner.
    HLI373 (3 μM) activates p53 transcription[1].
    HLI373 selectively inhibits auto-ubiquitylation of Hdm2[1].
    Co-transfection with plasmids encoding p53 and Hdm2 results in degradation of p53. Incubation with HLI373 (5-10 μM; 8 hours) blocks p53 degradation. HLI373 increases p53 and Hdm2 protein levels in cells[1].
    HLI 373 also shows lower IC50 values (below 6 μM) against both chloroquine-sensitive P. falciparum D6 strain (PfD6) and chloroquine-resistant P. falciparum W2 strain (PfW2) and exhibits early growth inhibition[2].
    HLI-373 is a MDM2 inhibitor interrupting its ubiquitin E3 ligase activity, could abolish the ubiquitylation of its substrate protein p53. HLI-373 targets the C-terminus functioning as an E3 ubiquitin ligase[3].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: Wild type p53 mouse embryo fibroblasts (MEFs), and p53-deficient MEFs
    Concentration: 3, 10, 15 μM
    Incubation Time: 15 hours
    Result: Increased cell death in wild type p53 MEFs in a dose-dependent manner, p53-deficient MEFs were relatively resistant.

    Western Blot Analysis[1]

    Cell Line: U2OS cells
    Concentration: 5, 10 μM
    Incubation Time: 8 hours
    Result: Blocked p53 degradation caused by co-transfection with plasmids encoding p53 and Hdm2.

    分子量

    341.41

    Formula

    C18H23N5O2
    CAS 号

    502137-98-6
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Jirouta Kitagaki, et al. Targeting Tumor Cells Expressing p53 With a Water-Soluble Inhibitor of Hdm2. Mol Cancer Ther. 2008 Aug;7(8):2445-54.

      [2]. Jagrati Jain, et al. Inhibitors of Ubiquitin E3 Ligase as Potential New Antimalarial Drug Leads. BMC Pharmacol Toxicol. 2017 Jun 2;18(1):40.

      [3]. Ying Chen, et al. MDM2 Promotes Epithelial-Mesenchymal Transition and Metastasis of Ovarian Cancer SKOV3 Cells. Br J Cancer. 2017 Oct 10;117(8):1192-1201.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    HLI373

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    HLI373 

    HLI373 是一种有效的 Hdm2 抑制剂。HLI373 抑制 Hdm2 泛素连接酶活性。HLI373 可有效诱导肿瘤细胞 (对 DNA 破坏剂敏感的) 凋亡 (apoptosis)。具有抗疟疾 (antimalarial) 活性。

    HLI373

    HLI373 Chemical Structure

    CAS No. : 502137-98-6

    规格 价格 是否有货
    5 mg ￥7500 询问价格 & 货期

    * Please select Quantity before adding items.

    生物活性

    HLI373 is an efficacious Hdm2 inhibitor. HLI373 inhibits the ubiquitin ligase activity of Hdm2. HLI373 is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents[1]. Antimalarial activity[2].

    IC50 & Target

    Hdm2[1]; Apoptosis[1]; Antimalarial[2]
    体外研究
    (In Vitro)

    HLI373 (3-15 μM; 15 hours) selectively kills tumor cells harboring wild type p53[1].
    HLI373 (10-50 μM) stabilizes cellular Hdm2 in a dose-dependent manner.
    HLI373 (3 μM) activates p53 transcription[1].
    HLI373 selectively inhibits auto-ubiquitylation of Hdm2[1].
    Co-transfection with plasmids encoding p53 and Hdm2 results in degradation of p53. Incubation with HLI373 (5-10 μM; 8 hours) blocks p53 degradation. HLI373 increases p53 and Hdm2 protein levels in cells[1].
    HLI 373 also shows lower IC50 values (below 6 μM) against both chloroquine-sensitive P. falciparum D6 strain (PfD6) and chloroquine-resistant P. falciparum W2 strain (PfW2) and exhibits early growth inhibition[2].
    HLI-373 is a MDM2 inhibitor interrupting its ubiquitin E3 ligase activity, could abolish the ubiquitylation of its substrate protein p53. HLI-373 targets the C-terminus functioning as an E3 ubiquitin ligase[3].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: Wild type p53 mouse embryo fibroblasts (MEFs), and p53-deficient MEFs
    Concentration: 3, 10, 15 μM
    Incubation Time: 15 hours
    Result: Increased cell death in wild type p53 MEFs in a dose-dependent manner, p53-deficient MEFs were relatively resistant.

    Western Blot Analysis[1]

    Cell Line: U2OS cells
    Concentration: 5, 10 μM
    Incubation Time: 8 hours
    Result: Blocked p53 degradation caused by co-transfection with plasmids encoding p53 and Hdm2.

    分子量

    341.41

    Formula

    C18H23N5O2
    CAS 号

    502137-98-6
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Jirouta Kitagaki, et al. Targeting Tumor Cells Expressing p53 With a Water-Soluble Inhibitor of Hdm2. Mol Cancer Ther. 2008 Aug;7(8):2445-54.

      [2]. Jagrati Jain, et al. Inhibitors of Ubiquitin E3 Ligase as Potential New Antimalarial Drug Leads. BMC Pharmacol Toxicol. 2017 Jun 2;18(1):40.

      [3]. Ying Chen, et al. MDM2 Promotes Epithelial-Mesenchymal Transition and Metastasis of Ovarian Cancer SKOV3 Cells. Br J Cancer. 2017 Oct 10;117(8):1192-1201.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    p53-HDM2-IN-1

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    p53-HDM2-IN-1 

    p53-HDM2-IN-1 是一种有效的 p53-HDM2 蛋白-蛋白相互作用抑制剂，IC50 值为 0.103 μM。p53-HDM2-IN-1 可用于癌症研究。

    p53-HDM2-IN-1

    p53-HDM2-IN-1 Chemical Structure

    规格 是否有货
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    生物活性

    p53-HDM2-IN-1 is a potent inhibitor of p53-HDM2 protein-protein interaction, with an IC50 of 0.103 μM. p53-HDM2-IN-1 can be used for the research of cancer[1].

    分子量

    786.78

    Formula

    C36H40F6N4O7S
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Tian Y, et, al. Phe19 modification of HDM2-p53 PPI inhibitors to alleviate CYP3A4 metabolism/mechanism-based inhibition liability. Bioorg Med Chem Lett. 2022 Apr 1;61:128625.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    p53-HDM2-IN-1

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    p53-HDM2-IN-1 

    p53-HDM2-IN-1 是一种有效的 p53-HDM2 蛋白-蛋白相互作用抑制剂，IC50 值为 0.103 μM。p53-HDM2-IN-1 可用于癌症研究。

    p53-HDM2-IN-1

    p53-HDM2-IN-1 Chemical Structure

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    p53-HDM2-IN-1 is a potent inhibitor of p53-HDM2 protein-protein interaction, with an IC50 of 0.103 μM. p53-HDM2-IN-1 can be used for the research of cancer[1].

    分子量

    786.78

    Formula

    C36H40F6N4O7S
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Tian Y, et, al. Phe19 modification of HDM2-p53 PPI inhibitors to alleviate CYP3A4 metabolism/mechanism-based inhibition liability. Bioorg Med Chem Lett. 2022 Apr 1;61:128625.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    p53-HDM2-IN-1

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    p53-HDM2-IN-1 

    p53-HDM2-IN-1 是一种有效的 p53-HDM2 蛋白-蛋白相互作用抑制剂，IC50 值为 0.103 μM。p53-HDM2-IN-1 可用于癌症研究。

    p53-HDM2-IN-1

    p53-HDM2-IN-1 Chemical Structure

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    p53-HDM2-IN-1 is a potent inhibitor of p53-HDM2 protein-protein interaction, with an IC50 of 0.103 μM. p53-HDM2-IN-1 can be used for the research of cancer[1].

    分子量

    786.78

    Formula

    C36H40F6N4O7S
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Tian Y, et, al. Phe19 modification of HDM2-p53 PPI inhibitors to alleviate CYP3A4 metabolism/mechanism-based inhibition liability. Bioorg Med Chem Lett. 2022 Apr 1;61:128625.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务