标签归档：inducer

Apoptosis inducer 4

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Apoptosis inducer 4 

Apoptosis inducer 4 (Compound 12b) 是一种具有抗癌活性的细胞凋亡 (apoptosis) 诱导剂。

Apoptosis inducer 4

Apoptosis inducer 4 Chemical Structure

CAS No. : 2408050-83-7

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生物活性

Apoptosis inducer 4 (Compound 12b) is an apoptosis inducer with anticancer activities[1].

体外研究
(In Vitro)

Apoptosis inducer 4 (Compound 12b) (0-50 µM, 72 h) shows antiproliferative activities against cancer cells without obvious cytotoxicity against normal cells[1].
Apoptosis inducer 4 (0-2 µM, 48 h) causes cell cycle arrest at S phase in K562 cells and G1 phase in HepG2 cells[1].
Apoptosis inducer 4 (0-4 µM, 24 and 48 h) induces pyknosis in K562 cells, and induces mitochondrial membrane potentials decline[1].
Apoptosis inducer 4 (0-2 µM, 72 h) induces apoptosis in K562 and HepG2 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: HepG2, MCF-7, HCT-116, B16, K562, L-02 and PBMC
Concentration: 0-50 µM
Incubation Time: 72 h
Result: Showed antiproliferative activities with IC50 values of 2.57 ± 0.12, 16.15 ± 1.02, 5.81 ± 1.17, 12.94 ± 0.88, 0.95 ± 0.06, 17.59 ± 0.93 and >50 µM against HepG2, MCF-7, HCT-116, B16, K562, L-02 and PBMC cells, respectively.

Cell Cycle Analysis[1]

Cell Line: K562 and HepG2 cells
Concentration: K562 and HepG2 cells
Incubation Time: 48 h
Result: Arrested K562 cell cycle at S phase and HepG2 cell at G1 phase.

Apoptosis Analysis[1]

Cell Line: K562 and HepG2 cells
Concentration: K562 and HepG2 cells
Incubation Time: 72 h
Result: Apoptotic ratios of K562 and HepG2 cells obviously increased in a concentration-dependent manner.

分子量

815.02

Formula

C41H50O11S3
CAS 号

2408050-83-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Li H, et al. Hydrogen sulfide releasing oridonin derivatives induce apoptosis through extrinsic and intrinsic pathways. Eur J Med Chem. 2020 Feb 1;187:111978.

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Autophagy inducer 4

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Autophagy inducer 4 

Autophagy inducer 4 是一种基于 Magnolol 的曼尼希碱衍生物，可用作抗癌剂。Autophagy inducer 4 通过诱导自噬 (autophagy) 来抑制癌细胞。Autophagy inducer 4 对 T47D 细胞的毒性是 Magnolol 的 76 倍。Autophagy inducer 4 对 T47D 和 Hela 癌细胞的迁移也有抑制作用。

Autophagy inducer 4

Autophagy inducer 4 Chemical Structure

CAS No. : 2486455-03-0

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生物活性

Autophagy inducer 4 is a Magnolol-based Mannich base derivatives, which can be used as an anticancer agent. Autophagy inducer 4 suppresses cancer cells via inducing autophagy. Autophagy inducer 4 has 76-fold improvement in cytotoxicity against T47D cells compared with Magnolol. Autophagy inducer 4 also possesses suppressive effects on migration of T47D and Hela cancer cells[1].

IC50 & Target

IC50: 0.91 μM in T47D, 3.32 μM in MCF-7, 1.71 μM in Hela[1]
体外研究
(In Vitro)

Autophagy inducer 4 (compound 3p) (0-10 μM; 72 hours) displays highly potent antiproliferative activity against T47D, MCF-7 and Hela cell lines[1].
Autophagy inducer 4 (40-80 μM; 0-36 hours) significantly increases GFP-LC3 protein puncta with both dose- and time-dependent manners in HEK293 cells[1].
Autophagy inducer 4 (0-80 μM; 0-36 hours) increases the transformation of LC3-I into LC3-II in a dose- and time-dependent manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line: T47D, MCF-7 and Hela cells[1]
Concentration: 0-10 μM
Incubation Time: 72 hours
Result: Displayed highly potent antiproliferative activity against T47D, MCF-7 and Hela cell lines with IC50 values of 0.91, 3.32 and 1.71 μM, respectively.

Cell Autophagy Assay

Cell Line: GFP-LC3-HEK293[1]
Concentration: 40, 60 and 80 μM
Incubation Time: 0, 12, 24 and 36 hours
Result: Significantly increased GFP-LC3 protein puncta with both dose- and time-dependent manners in HEK293 cells.

Western Blot Analysis

Cell Line: Hela, T47D and HEK293[1]
Concentration: 0, 5, 10 and 20 μM in T47D and Hela; 0, 40, 60 and 80 μM in HEK293
Incubation Time: 0, 12, 24 and 36 hours
Result: Increased the transformation of LC3-I into LC3-II in a dose-dependent manner, and enhanced the expression of LC3-II in a time-dependent manner.

分子量

531.64

Formula

C32H37NO6
CAS 号

2486455-03-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Xu T, et al. Semisynthesis of novel magnolol-based Mannich base derivatives that suppress cancer cells via inducing autophagy. Eur J Med Chem. 2020;205:112663.

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Autophagy inducer 2

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Autophagy inducer 2 

Autophagy inducer 2 (Compound 11i) 是一种有效的自噬诱导剂。Autophagy inducer 2 对 MCF-7 细胞系具有明显的抗增殖活性，IC50 值为 1.31 μM，并显着抑制 MCF-7 细胞的集落形成。Autophagy inducer 2 通过调节细胞周期相关蛋白 Cdk-1 和 Cyclin B1 将 MCF-7 细胞阻滞在 G2/M 期。Autophagy inducer 2具有研究乳腺癌的潜力。

Autophagy inducer 2

Autophagy inducer 2 Chemical Structure

CAS No. : 2684238-37-5

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生物活性

Autophagy inducer 2 (Compound 11i) is a potent autophagy inducer. Autophagy inducer 2 exhibits apparent antiproliferative activity against the MCF-7 cell line with an IC50 value of 1.31 μM and remarkably inhibits the colony formation of the MCF-7 cells. Autophagy inducer 2 arrests the MCF-7 cells in the G2/M phase by regulating the cell-cycle-related proteins Cdk-1 and Cyclin B1. Autophagy inducer 2 has the potential for the research of breast cancer[1].

分子量

650.94

Formula

C41H58N6O
CAS 号

2684238-37-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Feng Y, et al. Scaffold hopping of celastrol provides derivatives containing pepper ring, pyrazine and oxazole substructures as potent autophagy inducers against breast cancer cell line MCF-7. Eur J Med Chem. 2022;234:114254.

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Autophagy inducer 2

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Autophagy inducer 2 

Autophagy inducer 2 (Compound 11i) 是一种有效的自噬诱导剂。Autophagy inducer 2 对 MCF-7 细胞系具有明显的抗增殖活性，IC50 值为 1.31 μM，并显着抑制 MCF-7 细胞的集落形成。Autophagy inducer 2 通过调节细胞周期相关蛋白 Cdk-1 和 Cyclin B1 将 MCF-7 细胞阻滞在 G2/M 期。Autophagy inducer 2具有研究乳腺癌的潜力。

Autophagy inducer 2

Autophagy inducer 2 Chemical Structure

CAS No. : 2684238-37-5

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生物活性

Autophagy inducer 2 (Compound 11i) is a potent autophagy inducer. Autophagy inducer 2 exhibits apparent antiproliferative activity against the MCF-7 cell line with an IC50 value of 1.31 μM and remarkably inhibits the colony formation of the MCF-7 cells. Autophagy inducer 2 arrests the MCF-7 cells in the G2/M phase by regulating the cell-cycle-related proteins Cdk-1 and Cyclin B1. Autophagy inducer 2 has the potential for the research of breast cancer[1].

分子量

650.94

Formula

C41H58N6O
CAS 号

2684238-37-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Feng Y, et al. Scaffold hopping of celastrol provides derivatives containing pepper ring, pyrazine and oxazole substructures as potent autophagy inducers against breast cancer cell line MCF-7. Eur J Med Chem. 2022;234:114254.

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Autophagy inducer 2

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Autophagy inducer 2 

Autophagy inducer 2 (Compound 11i) 是一种有效的自噬诱导剂。Autophagy inducer 2 对 MCF-7 细胞系具有明显的抗增殖活性，IC50 值为 1.31 μM，并显着抑制 MCF-7 细胞的集落形成。Autophagy inducer 2 通过调节细胞周期相关蛋白 Cdk-1 和 Cyclin B1 将 MCF-7 细胞阻滞在 G2/M 期。Autophagy inducer 2具有研究乳腺癌的潜力。

Autophagy inducer 2

Autophagy inducer 2 Chemical Structure

CAS No. : 2684238-37-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Autophagy inducer 2 (Compound 11i) is a potent autophagy inducer. Autophagy inducer 2 exhibits apparent antiproliferative activity against the MCF-7 cell line with an IC50 value of 1.31 μM and remarkably inhibits the colony formation of the MCF-7 cells. Autophagy inducer 2 arrests the MCF-7 cells in the G2/M phase by regulating the cell-cycle-related proteins Cdk-1 and Cyclin B1. Autophagy inducer 2 has the potential for the research of breast cancer[1].

分子量

650.94

Formula

C41H58N6O
CAS 号

2684238-37-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Feng Y, et al. Scaffold hopping of celastrol provides derivatives containing pepper ring, pyrazine and oxazole substructures as potent autophagy inducers against breast cancer cell line MCF-7. Eur J Med Chem. 2022;234:114254.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Autophagy inducer 3

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Autophagy inducer 3 

Autophagy inducer 3 具有细胞自噬 (autophagy) 诱导活性。Autophagy inducer 3 能强烈地诱导不同癌细胞死亡，而不影响正常细胞。Autophagy inducer 3 通过形成特征性的自噬空泡、形成 LC3 点状体、上调自噬标志蛋白 Beclin 和 Atg 家族蛋白等，来诱导细胞自噬。

Autophagy inducer 3

Autophagy inducer 3 Chemical Structure

CAS No. : 2691054-63-2

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生物活性

Autophagy inducer 3 has autophagy induced activity. Autophagy inducer 3 possesses robust autophagic cell death in diverse cancer cells sparing normal counterpart. Autophagy inducer 3 induces lethal autophagy by formation of characteristic autophagic vacuoles, LC3 puncta formation, upregulation of signature autophagy markers like Beclin and Atg family proteins[1].

IC50 & Target

Autophagy[1]
体外研究
(In Vitro)

Autophagy inducer 3 (compound 26b) (10 μM; 48 hours) effectively inhibits cell growth in diverse breast, lung and colon cancer cell lines[1].
Autophagy inducer 3 (0-10 μM; 48 hours) exhibits potent antiproliferative activity in COLO-205, LOVO, HT-29, DLD-1, SW48 and SW-620 with IC50s of 2.03 μM, 3.33 μM, 4.15 μM, 4.46 μM, 3.14 μM, 1.86 μM, respectively; and shows low cytotoxicity in normal human colon fibroblast CCD-18Co with IC50 over 10 μM[1].
Autophagy inducer 3 (7.5 μM; 18 hours) promotes non apoptotic cell death in DLD-1 cells by cellular granularity through vacuole formation and increase Annexin-V positive cells as well as PARP cleavage; and robustly induces the expression of classical autophagy markers like Beclin-1, Atg3, Atg5 and Atg7[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line: MCF-7, MDA-MB-231, DLD-1, HT-29, A549 and NCI-H358[1]
Concentration: 10 μM
Incubation Time: 48 hours
Result: Effectively inhibited cell growth at 10 μM dose in diverse cancer cell lines with the inhibition rates of 89.28~97.66%.

Cell Autophagy Assay

Cell Line: DLD-1[1]
Concentration: 7.5 μM
Incubation Time: 18 hours
Result: Promoted intracytoplasmic vacuole accumulation in colon cancer (DLD-1) cells; and robustly induced the expression of classical autophagy markers like Beclin-1, Atg3, Atg5 and Atg7.

分子量

377.60

Formula

C24H43NO2
CAS 号

2691054-63-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ganesher A, et al. New Spisulosine Derivative promotes robust autophagic response to cancer cells. Eur J Med Chem. 2020;188:112011.

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Methuosis inducer 1

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Methuosis inducer 1  纯度: 98.00%

Methuosis inducer 1 是一种有效的 methuosis 诱导剂。具有抗肿瘤活性。

Methuosis inducer 1

Methuosis inducer 1 Chemical Structure

CAS No. : 2240205-30-3

规格 价格 是否有货 数量
5 mg ￥2900 In-stock
10 mg ￥4500 In-stock
25 mg ￥8500 In-stock
50 mg ￥13500 In-stock
100 mg   询价  
200 mg   询价  

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Methuosis inducer 1 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Anti-Cancer Compound Library

生物活性

Methuosis inducer 1 is a potent methuosis inducer[1]. Anticancer activity[1].

IC50 & Target

Methuosis[1]
体外研究
(In Vitro)

Methuosis inducer 1 (Compound 13) shows a broad spectrum of cytotoxicity against a panel of human cancer cell lines with IC50 values of 0.326±0.026 μM, 1.370±0.061 μM, 1.662±0.128 μM, 1.892±0.092 μM, 1.571±0.066 μM, 2.268±0.100 μM, 2.611±0.739 μM, 1.008±0.042 μM, 1.566±0.015 μM, and 1.197±0.344 μM for A375, SK-MEL-28, SK-MEL-30, A549, MDA-MB-231, MDA-MB-435S, MCF-7, HCT116, BGC823, HepG2 cells, respectively[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

487.48

Formula

C27H20F3N5O
CAS 号

2240205-30-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 25 mg/mL (51.28 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0514 mL 10.2568 mL 20.5137 mL
5 mM 0.4103 mL 2.0514 mL 4.1027 mL
10 mM 0.2051 mL 1.0257 mL 2.0514 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (5.13 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.5 mg/mL (5.13 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 2.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (4.45 mM); Clear solution

    此方案可获得 ≥ 2.17 mg/mL (4.45 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 21.7 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.27 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.27 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Huang W, et al. Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor Activities. J Med Chem. 2018 Jun 28;61(12):5424-5434.

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Apoptosis inducer 5

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Apoptosis inducer 5 

Apoptosis inducer 5 (compound 1b) 是一种木脂素对映异构体，存在于 Crataegus pinnatifida 中。Apoptosis inducer 5 通过 Hep3B 细胞中的凋亡和自噬表现出细胞毒性作用。

Apoptosis inducer 5 Apoptosis inducer 5

Apoptosis inducer 5 Chemical Structure

规格 是否有货
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生物活性

Apoptosis inducer 5 (compound 1b) is a lignan enantiomer that can be found in Crataegus pinnatifida. Apoptosis inducer 5 exhibits cytotoxic effect via apoptosis and autophagy in Hep3B cells[1].

分子量

414.45

Formula

C23H26O7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Shang XY, et, al. Enantiomeric 8-O-4′-type neolignans from Crataegus pinnatifida exhibit cytotoxic effect via apoptosis and autophagy in Hep3B cells. Bioorg Chem. 2020 Nov;104:104267.

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Apoptosis inducer 2

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Apoptosis inducer 2 

Apoptosis inducer 2 (Compound 2) 是一种凋亡 (apoptosis) 诱导因子，主要触发细胞坏死。Apoptosis inducer 2 对癌细胞具有毒性。

Apoptosis inducer 2

Apoptosis inducer 2 Chemical Structure

CAS No. : 2420443-12-3

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生物活性

Apoptosis inducer 2 (Compound 2) is an apoptosis inducer that mainly triggers necrosis. Apoptosis inducer 2 shows cytotoxicity against cancer cells[1].

分子量

749.42

Formula

C47H57ClN2O4
CAS 号

2420443-12-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Serbian I, et al. Synthesis of some steroidal mitocans of nanomolar cytotoxicity acting by apoptosis. Eur J Med Chem. 2020 Aug 1;199:112425.

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Apoptosis inducer 3

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Apoptosis inducer 3 

Apoptosis inducer 3 (Compound 3) 是一种凋亡 (apoptosis) 诱导因子，可选择性触发细胞凋亡和晚期细胞凋亡。Apoptosis inducer 3 对癌细胞具有毒性。

Apoptosis inducer 3

Apoptosis inducer 3 Chemical Structure

CAS No. : 2420443-14-5

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250 mg   询价  
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生物活性

Apoptosis inducer 3 (Compound 3) is an apoptosis inducer that selectively triggers apoptosis and late-apoptosis. Apoptosis inducer 3 shows cytotoxicity against cancer cells[1].

分子量

819.42

Formula

C49H55ClN2O7
CAS 号

2420443-14-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Serbian I, et al. Synthesis of some steroidal mitocans of nanomolar cytotoxicity acting by apoptosis. Eur J Med Chem. 2020 Aug 1;199:112425.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ROS-ERS inducer 1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ROS-ERS inducer 1 

ROS-ERS inducer 1 是一种 II 型 ICD (免疫原性细胞死亡) 诱导剂。ROS-ERS inducer 1 是一种源自 4,5-二芳基咪唑的 Pt(II)-N-杂环卡宾 (Pt(II)-NHC) 复合物。ROS-ERS inducer 1 成功诱导内质网应激 (ERS) 伴随活性氧 (ROS) 的产生，并最终导致 HCC 细胞中损伤相关分子模式 (DAMP) 的释放。ROS-ERS inducer 1 显示出比 Cisplatin 高得多的抗癌活性。

ROS-ERS inducer 1

ROS-ERS inducer 1 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

ROS-ERS inducer 1 is a type II ICD (immunogenic cell death) inducer. ROS-ERS inducer 1 is a Pt(II)-N-heterocyclic carbene (Pt(II)-NHC) complex derived from 4,5-diarylimidazole. ROS-ERS inducer 1 successfully induces endoplasmic reticulum stress (ERS) accompanied by reactive oxygen species (ROS) generation and finally lead to the release of damage-associated molecular patterns (DAMPs) in HCC cells. ROS-ERS inducer 1 displays much higher anticancer activities than Cisplatin[1].

分子量

841.36

Formula

C24H24F2I2N3Pt
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Bian M, et al. Pt(II)-NHC Complex Induces ROS-ERS-Related DAMP Balance to Harness Immunogenic Cell Death in Hepatocellular Carcinoma. J Med Chem. 2022;65(3):1848-1866.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ROS-ERS inducer 1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ROS-ERS inducer 1 

ROS-ERS inducer 1 是一种 II 型 ICD (免疫原性细胞死亡) 诱导剂。ROS-ERS inducer 1 是一种源自 4,5-二芳基咪唑的 Pt(II)-N-杂环卡宾 (Pt(II)-NHC) 复合物。ROS-ERS inducer 1 成功诱导内质网应激 (ERS) 伴随活性氧 (ROS) 的产生，并最终导致 HCC 细胞中损伤相关分子模式 (DAMP) 的释放。ROS-ERS inducer 1 显示出比 Cisplatin 高得多的抗癌活性。

ROS-ERS inducer 1

ROS-ERS inducer 1 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

ROS-ERS inducer 1 is a type II ICD (immunogenic cell death) inducer. ROS-ERS inducer 1 is a Pt(II)-N-heterocyclic carbene (Pt(II)-NHC) complex derived from 4,5-diarylimidazole. ROS-ERS inducer 1 successfully induces endoplasmic reticulum stress (ERS) accompanied by reactive oxygen species (ROS) generation and finally lead to the release of damage-associated molecular patterns (DAMPs) in HCC cells. ROS-ERS inducer 1 displays much higher anticancer activities than Cisplatin[1].

分子量

841.36

Formula

C24H24F2I2N3Pt
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Bian M, et al. Pt(II)-NHC Complex Induces ROS-ERS-Related DAMP Balance to Harness Immunogenic Cell Death in Hepatocellular Carcinoma. J Med Chem. 2022;65(3):1848-1866.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ROS-ERS inducer 1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ROS-ERS inducer 1 

ROS-ERS inducer 1 是一种 II 型 ICD (免疫原性细胞死亡) 诱导剂。ROS-ERS inducer 1 是一种源自 4,5-二芳基咪唑的 Pt(II)-N-杂环卡宾 (Pt(II)-NHC) 复合物。ROS-ERS inducer 1 成功诱导内质网应激 (ERS) 伴随活性氧 (ROS) 的产生，并最终导致 HCC 细胞中损伤相关分子模式 (DAMP) 的释放。ROS-ERS inducer 1 显示出比 Cisplatin 高得多的抗癌活性。

ROS-ERS inducer 1

ROS-ERS inducer 1 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

ROS-ERS inducer 1 is a type II ICD (immunogenic cell death) inducer. ROS-ERS inducer 1 is a Pt(II)-N-heterocyclic carbene (Pt(II)-NHC) complex derived from 4,5-diarylimidazole. ROS-ERS inducer 1 successfully induces endoplasmic reticulum stress (ERS) accompanied by reactive oxygen species (ROS) generation and finally lead to the release of damage-associated molecular patterns (DAMPs) in HCC cells. ROS-ERS inducer 1 displays much higher anticancer activities than Cisplatin[1].

分子量

841.36

Formula

C24H24F2I2N3Pt
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Bian M, et al. Pt(II)-NHC Complex Induces ROS-ERS-Related DAMP Balance to Harness Immunogenic Cell Death in Hepatocellular Carcinoma. J Med Chem. 2022;65(3):1848-1866.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务