标签归档：inhibitor

PPIase-Parvulin inhibitor

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PPIase-Parvulin inhibitor 

PPIase-Parvulin inhibitor 是 PPIase Pin1 和 Pin4 的细胞渗透性抑制剂，其 IC50s 分别为 1.5 和 1.0 µM。

PPIase-Parvulin inhibitor

PPIase-Parvulin inhibitor Chemical Structure

CAS No. : 64005-90-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PPIase-Parvulin Inhibitor is a cell-permeable inhibitor of the PPIases Pin1 and Pin4 with IC50s of 1.5 and 1.0 µM, respectively[1].

分子量

438.39

Formula

C22H18N2O8
CAS 号

64005-90-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Uchida T, et al. Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chem Biol. 2003 Jan;10(1):15-24.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Mcl-1 inhibitor 8

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Mcl-1 inhibitor 8 

Mcl-1 inhibitor 8 是一种 MCL-1 抑制剂，例 228，从专利 WO2019222112 中获得.

Mcl-1 inhibitor 8

Mcl-1 inhibitor 8 Chemical Structure

CAS No. : 2388471-31-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Mcl-1 inhibitor 8 is a MCL-1 inhibitor, example 228, extracted from patent WO2019222112[1].

分子量

736.32

Formula

C38H46ClN5O6S
CAS 号

2388471-31-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hang CHU, et al. Inhibiteurs de mcl-1. Patent WO2019222112.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PPIase-Parvulin inhibitor

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PPIase-Parvulin inhibitor 

PPIase-Parvulin inhibitor 是 PPIase Pin1 和 Pin4 的细胞渗透性抑制剂，其 IC50s 分别为 1.5 和 1.0 µM。

PPIase-Parvulin inhibitor

PPIase-Parvulin inhibitor Chemical Structure

CAS No. : 64005-90-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PPIase-Parvulin Inhibitor is a cell-permeable inhibitor of the PPIases Pin1 and Pin4 with IC50s of 1.5 and 1.0 µM, respectively[1].

分子量

438.39

Formula

C22H18N2O8
CAS 号

64005-90-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Uchida T, et al. Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chem Biol. 2003 Jan;10(1):15-24.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PPIase-Parvulin inhibitor

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PPIase-Parvulin inhibitor 

PPIase-Parvulin inhibitor 是 PPIase Pin1 和 Pin4 的细胞渗透性抑制剂，其 IC50s 分别为 1.5 和 1.0 µM。

PPIase-Parvulin inhibitor

PPIase-Parvulin inhibitor Chemical Structure

CAS No. : 64005-90-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PPIase-Parvulin Inhibitor is a cell-permeable inhibitor of the PPIases Pin1 and Pin4 with IC50s of 1.5 and 1.0 µM, respectively[1].

分子量

438.39

Formula

C22H18N2O8
CAS 号

64005-90-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Uchida T, et al. Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chem Biol. 2003 Jan;10(1):15-24.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Mcl-1 inhibitor 8

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Mcl-1 inhibitor 8 

Mcl-1 inhibitor 8 是一种 MCL-1 抑制剂，例 228，从专利 WO2019222112 中获得.

Mcl-1 inhibitor 8

Mcl-1 inhibitor 8 Chemical Structure

CAS No. : 2388471-31-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Mcl-1 inhibitor 8 is a MCL-1 inhibitor, example 228, extracted from patent WO2019222112[1].

分子量

736.32

Formula

C38H46ClN5O6S
CAS 号

2388471-31-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hang CHU, et al. Inhibiteurs de mcl-1. Patent WO2019222112.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Mcl-1 inhibitor 8

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Mcl-1 inhibitor 8 

Mcl-1 inhibitor 8 是一种 MCL-1 抑制剂，例 228，从专利 WO2019222112 中获得.

Mcl-1 inhibitor 8

Mcl-1 inhibitor 8 Chemical Structure

CAS No. : 2388471-31-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Mcl-1 inhibitor 8 is a MCL-1 inhibitor, example 228, extracted from patent WO2019222112[1].

分子量

736.32

Formula

C38H46ClN5O6S
CAS 号

2388471-31-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hang CHU, et al. Inhibiteurs de mcl-1. Patent WO2019222112.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Tubulin inhibitor 24

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Tubulin inhibitor 24 

Tubulin inhibitor 24 是一种有效的 tubulin 抑制剂。Tubulin inhibitor 24 抑制微管蛋白聚合。Tubulin inhibitor 24 以浓度依赖性方式诱导细胞周期停滞在 G2/M 期。Tubulin inhibitor 24 具有抗肿瘤活性且无明显毒性。

Tubulin inhibitor 24

Tubulin inhibitor 24 Chemical Structure

CAS No. : 2415761-65-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Tubulin inhibitor 24 is a potent tubulin inhibitor. Tubulin inhibitor 24 inhibits tubulin polymerization. Tubulin inhibitor 24 induces cell cycle arrest at the G2/M phase in a concentration-dependent manner. Tubulin inhibitor 24 shows antitumor activity with no obvious toxicity[1].

体外研究
(In Vitro)

Tubulin inhibitor 24 (compound 1b) () shows high antiproliferative activity with IC50s of 0.021, 0.047, 0.003, 0.048 µM for Hela, MCF-7, A549, HCT-116, B16-F10 cells, respectively[1].
Tubulin inhibitor 24 inhibites tubulin polymerization with an IC50 value of 2.1 µM[1].
Tubulin inhibitor 24 (5, 10 nM) induces cell cycle arrest at the G2/M phase in a concentration-dependent manner[1].
Tubulin inhibitor 24 (10, 20, 40 nM; 24 h) inhibits MCF-7 cancer cells migration in a dose-dependent manner[1].
Tubulin inhibitor 24 (40 nM; 6 h) destabilizes microtubule by inhibiting tubulin polymerization and disturbing microtubule networks in B16-F10 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Hela, MCF-7, A549, HCT-116, B16-F10 cells
Concentration: 0.00098, 0.0039, 0.016, 0.0625, 0.25, 1.0, 4.0, 16, 64 µM
Incubation Time: 48 h
Result: Showed high antiproliferative activity with IC50s of 0.021, 0.047, 0.003, 0.048 µM for Hela, MCF-7, A549, HCT-116, B16-F10 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 5, 10 nM
Incubation Time: 48 h
Result: Cells were arrested at the G2/M phase in a concentration-dependent manner.

体内研究
(In Vivo)

Tubulin inhibitor 24 (10, 20 mg/kg; i.p.; per day for 16 days) shows antitumor activity with no obvious toxicity[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-6 weeks, male C57/BL mice (B16e-10 tumor model)[1]
Dosage: 10, 20 mg/kg (formulated in 5% DMSO, 40% PEG-300 and 55% saline)
Administration: I.p.; per day, 16 days
Result: Showed antitumor activity with no obvious toxicity.

分子量

375.42

Formula

C22H21N3O3
CAS 号

2415761-65-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Li G,et al. Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities. Eur J Med Chem. 2020; 202:112519.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Tubulin inhibitor 24

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Tubulin inhibitor 24 

Tubulin inhibitor 24 是一种有效的 tubulin 抑制剂。Tubulin inhibitor 24 抑制微管蛋白聚合。Tubulin inhibitor 24 以浓度依赖性方式诱导细胞周期停滞在 G2/M 期。Tubulin inhibitor 24 具有抗肿瘤活性且无明显毒性。

Tubulin inhibitor 24

Tubulin inhibitor 24 Chemical Structure

CAS No. : 2415761-65-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Tubulin inhibitor 24 is a potent tubulin inhibitor. Tubulin inhibitor 24 inhibits tubulin polymerization. Tubulin inhibitor 24 induces cell cycle arrest at the G2/M phase in a concentration-dependent manner. Tubulin inhibitor 24 shows antitumor activity with no obvious toxicity[1].

体外研究
(In Vitro)

Tubulin inhibitor 24 (compound 1b) () shows high antiproliferative activity with IC50s of 0.021, 0.047, 0.003, 0.048 µM for Hela, MCF-7, A549, HCT-116, B16-F10 cells, respectively[1].
Tubulin inhibitor 24 inhibites tubulin polymerization with an IC50 value of 2.1 µM[1].
Tubulin inhibitor 24 (5, 10 nM) induces cell cycle arrest at the G2/M phase in a concentration-dependent manner[1].
Tubulin inhibitor 24 (10, 20, 40 nM; 24 h) inhibits MCF-7 cancer cells migration in a dose-dependent manner[1].
Tubulin inhibitor 24 (40 nM; 6 h) destabilizes microtubule by inhibiting tubulin polymerization and disturbing microtubule networks in B16-F10 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Hela, MCF-7, A549, HCT-116, B16-F10 cells
Concentration: 0.00098, 0.0039, 0.016, 0.0625, 0.25, 1.0, 4.0, 16, 64 µM
Incubation Time: 48 h
Result: Showed high antiproliferative activity with IC50s of 0.021, 0.047, 0.003, 0.048 µM for Hela, MCF-7, A549, HCT-116, B16-F10 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 5, 10 nM
Incubation Time: 48 h
Result: Cells were arrested at the G2/M phase in a concentration-dependent manner.

体内研究
(In Vivo)

Tubulin inhibitor 24 (10, 20 mg/kg; i.p.; per day for 16 days) shows antitumor activity with no obvious toxicity[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-6 weeks, male C57/BL mice (B16e-10 tumor model)[1]
Dosage: 10, 20 mg/kg (formulated in 5% DMSO, 40% PEG-300 and 55% saline)
Administration: I.p.; per day, 16 days
Result: Showed antitumor activity with no obvious toxicity.

分子量

375.42

Formula

C22H21N3O3
CAS 号

2415761-65-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Li G,et al. Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities. Eur J Med Chem. 2020; 202:112519.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Tubulin inhibitor 24

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Tubulin inhibitor 24 

Tubulin inhibitor 24 是一种有效的 tubulin 抑制剂。Tubulin inhibitor 24 抑制微管蛋白聚合。Tubulin inhibitor 24 以浓度依赖性方式诱导细胞周期停滞在 G2/M 期。Tubulin inhibitor 24 具有抗肿瘤活性且无明显毒性。

Tubulin inhibitor 24

Tubulin inhibitor 24 Chemical Structure

CAS No. : 2415761-65-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Tubulin inhibitor 24 is a potent tubulin inhibitor. Tubulin inhibitor 24 inhibits tubulin polymerization. Tubulin inhibitor 24 induces cell cycle arrest at the G2/M phase in a concentration-dependent manner. Tubulin inhibitor 24 shows antitumor activity with no obvious toxicity[1].

体外研究
(In Vitro)

Tubulin inhibitor 24 (compound 1b) () shows high antiproliferative activity with IC50s of 0.021, 0.047, 0.003, 0.048 µM for Hela, MCF-7, A549, HCT-116, B16-F10 cells, respectively[1].
Tubulin inhibitor 24 inhibites tubulin polymerization with an IC50 value of 2.1 µM[1].
Tubulin inhibitor 24 (5, 10 nM) induces cell cycle arrest at the G2/M phase in a concentration-dependent manner[1].
Tubulin inhibitor 24 (10, 20, 40 nM; 24 h) inhibits MCF-7 cancer cells migration in a dose-dependent manner[1].
Tubulin inhibitor 24 (40 nM; 6 h) destabilizes microtubule by inhibiting tubulin polymerization and disturbing microtubule networks in B16-F10 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Hela, MCF-7, A549, HCT-116, B16-F10 cells
Concentration: 0.00098, 0.0039, 0.016, 0.0625, 0.25, 1.0, 4.0, 16, 64 µM
Incubation Time: 48 h
Result: Showed high antiproliferative activity with IC50s of 0.021, 0.047, 0.003, 0.048 µM for Hela, MCF-7, A549, HCT-116, B16-F10 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 5, 10 nM
Incubation Time: 48 h
Result: Cells were arrested at the G2/M phase in a concentration-dependent manner.

体内研究
(In Vivo)

Tubulin inhibitor 24 (10, 20 mg/kg; i.p.; per day for 16 days) shows antitumor activity with no obvious toxicity[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-6 weeks, male C57/BL mice (B16e-10 tumor model)[1]
Dosage: 10, 20 mg/kg (formulated in 5% DMSO, 40% PEG-300 and 55% saline)
Administration: I.p.; per day, 16 days
Result: Showed antitumor activity with no obvious toxicity.

分子量

375.42

Formula

C22H21N3O3
CAS 号

2415761-65-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Li G,et al. Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities. Eur J Med Chem. 2020; 202:112519.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

K-Ras(G12C) inhibitor 6

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

K-Ras(G12C) inhibitor 6 

KRas(G12C) inhibitor 6 是 KRas(G12C) 突变体的不可逆变构抑制剂。

K-Ras(G12C) inhibitor 6

K-Ras(G12C) inhibitor 6 Chemical Structure

CAS No. : 2060530-16-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C)[1].

IC50 & Target

K-Ras(G12C)

 

分子量

405.34

Formula

C17H22Cl2N2O3S
CAS 号

2060530-16-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-51.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

K-Ras(G12C) inhibitor 6

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

K-Ras(G12C) inhibitor 6 

KRas(G12C) inhibitor 6 是 KRas(G12C) 突变体的不可逆变构抑制剂。

K-Ras(G12C) inhibitor 6

K-Ras(G12C) inhibitor 6 Chemical Structure

CAS No. : 2060530-16-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C)[1].

IC50 & Target

K-Ras(G12C)

 

分子量

405.34

Formula

C17H22Cl2N2O3S
CAS 号

2060530-16-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-51.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

KRAS G12C inhibitor 41

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

KRAS G12C inhibitor 41 

KRAS G12C inhibitor 40 是一种有效的 KRAS G12C 抑制剂。Ras 蛋白家族是一种重要的细胞内信号分子，在生长发育中起重要作用。KRAS G12C inhibitor 40 具有研究 KRAS G12C 介导的癌症的潜力 (摘自专利 WO2021129824A1，化合物 121)。

KRAS G12C inhibitor 41

KRAS G12C inhibitor 41 Chemical Structure

CAS No. : 2660014-65-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

KRAS G12C inhibitor 41 is a potent inhibitor of KRAS G12C. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12C inhibitor 41 has the potential for the research of KRAS G12C-mediated cancer (extracted from patent WO2021129824A1, compound 121)[1].

分子量

682.19

Formula

C36H37ClFN9O2
CAS 号

2660014-65-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yuli Xie, et al. Novel K-Ras G12C inhibitor. Patent WO2021129824A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

K-Ras(G12C) inhibitor 6

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

K-Ras(G12C) inhibitor 6 

KRas(G12C) inhibitor 6 是 KRas(G12C) 突变体的不可逆变构抑制剂。

K-Ras(G12C) inhibitor 6

K-Ras(G12C) inhibitor 6 Chemical Structure

CAS No. : 2060530-16-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C)[1].

IC50 & Target

K-Ras(G12C)

 

分子量

405.34

Formula

C17H22Cl2N2O3S
CAS 号

2060530-16-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-51.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

KRAS G12D inhibitor 11

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

KRAS G12D inhibitor 11 

KRAS G12D inhibitor 11 是一种有效的 KRAS G12D 抑制剂。Ras 蛋白家族是一种重要的细胞内信号分子，在生长发育中起重要作用。KRAS G12D inhibitor 11 具有研究 KRAS G12D 介导的癌症的潜力 (摘自专利 WO2021108683A1，化合物 52)。

KRAS G12D inhibitor 11

KRAS G12D inhibitor 11 Chemical Structure

CAS No. : 2648551-72-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

KRAS G12D inhibitor 11 is a potent inhibitor of KRAS G12D. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 11 has the potential for the research of KRAS G12D-mediated cancer (extracted from patent WO2021108683A1, compound 52)[1].

分子量

515.45

Formula

C29H38BN5O3
CAS 号

2648551-72-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jennifer PITZEN, et al. Covalent ras inhibitors and uses thereof. Patent WO2021108683A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

KRAS G12C inhibitor 41

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

KRAS G12C inhibitor 41 

KRAS G12C inhibitor 40 是一种有效的 KRAS G12C 抑制剂。Ras 蛋白家族是一种重要的细胞内信号分子，在生长发育中起重要作用。KRAS G12C inhibitor 40 具有研究 KRAS G12C 介导的癌症的潜力 (摘自专利 WO2021129824A1，化合物 121)。

KRAS G12C inhibitor 41

KRAS G12C inhibitor 41 Chemical Structure

CAS No. : 2660014-65-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

KRAS G12C inhibitor 41 is a potent inhibitor of KRAS G12C. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12C inhibitor 41 has the potential for the research of KRAS G12C-mediated cancer (extracted from patent WO2021129824A1, compound 121)[1].

分子量

682.19

Formula

C36H37ClFN9O2
CAS 号

2660014-65-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yuli Xie, et al. Novel K-Ras G12C inhibitor. Patent WO2021129824A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

KRAS G12C inhibitor 41

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

KRAS G12C inhibitor 41 

KRAS G12C inhibitor 40 是一种有效的 KRAS G12C 抑制剂。Ras 蛋白家族是一种重要的细胞内信号分子，在生长发育中起重要作用。KRAS G12C inhibitor 40 具有研究 KRAS G12C 介导的癌症的潜力 (摘自专利 WO2021129824A1，化合物 121)。

KRAS G12C inhibitor 41

KRAS G12C inhibitor 41 Chemical Structure

CAS No. : 2660014-65-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

KRAS G12C inhibitor 41 is a potent inhibitor of KRAS G12C. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12C inhibitor 41 has the potential for the research of KRAS G12C-mediated cancer (extracted from patent WO2021129824A1, compound 121)[1].

分子量

682.19

Formula

C36H37ClFN9O2
CAS 号

2660014-65-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yuli Xie, et al. Novel K-Ras G12C inhibitor. Patent WO2021129824A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

KRAS G12D inhibitor 11

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

KRAS G12D inhibitor 11 

KRAS G12D inhibitor 11 是一种有效的 KRAS G12D 抑制剂。Ras 蛋白家族是一种重要的细胞内信号分子，在生长发育中起重要作用。KRAS G12D inhibitor 11 具有研究 KRAS G12D 介导的癌症的潜力 (摘自专利 WO2021108683A1，化合物 52)。

KRAS G12D inhibitor 11

KRAS G12D inhibitor 11 Chemical Structure

CAS No. : 2648551-72-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

KRAS G12D inhibitor 11 is a potent inhibitor of KRAS G12D. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 11 has the potential for the research of KRAS G12D-mediated cancer (extracted from patent WO2021108683A1, compound 52)[1].

分子量

515.45

Formula

C29H38BN5O3
CAS 号

2648551-72-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jennifer PITZEN, et al. Covalent ras inhibitors and uses thereof. Patent WO2021108683A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

KRAS G12D inhibitor 11

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

KRAS G12D inhibitor 11 

KRAS G12D inhibitor 11 是一种有效的 KRAS G12D 抑制剂。Ras 蛋白家族是一种重要的细胞内信号分子，在生长发育中起重要作用。KRAS G12D inhibitor 11 具有研究 KRAS G12D 介导的癌症的潜力 (摘自专利 WO2021108683A1，化合物 52)。

KRAS G12D inhibitor 11

KRAS G12D inhibitor 11 Chemical Structure

CAS No. : 2648551-72-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

KRAS G12D inhibitor 11 is a potent inhibitor of KRAS G12D. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 11 has the potential for the research of KRAS G12D-mediated cancer (extracted from patent WO2021108683A1, compound 52)[1].

分子量

515.45

Formula

C29H38BN5O3
CAS 号

2648551-72-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jennifer PITZEN, et al. Covalent ras inhibitors and uses thereof. Patent WO2021108683A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

KRAS G12C inhibitor 39

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

KRAS G12C inhibitor 39 

KRAS G12C inhibitor 39 是一种有效的 KRAS G12C 抑制剂。KRas 是制药行业癌症研究的一个极具吸引力的目标。KRAS G12C inhibitor 39 具有研究 KRAS G12C 介导的癌症的潜力 (摘自专利 WO2019099524A1，化合物 494)。

KRAS G12C inhibitor 39

KRAS G12C inhibitor 39 Chemical Structure

CAS No. : 2326522-16-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

KRAS G12C inhibitor 39 is a potent inhibitor of KRAS G12C. KRas is a highly attractable target of the pharmaceutical industry for cancer research. KRAS G12C inhibitor 39 has the potential for the research of KRAS G12C-mediated cancer (extracted from patent WO2019099524A1, compound 494)[1].

分子量

645.80

Formula

C37H43N9O2
CAS 号

2326522-16-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. James F. Blake, et al. Kras g12c inhibitors. Patent WO2019099524A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

KRAS G12C inhibitor 40

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

KRAS G12C inhibitor 40 

KRAS G12C inhibitor 40 是一种有效的 KRAS G12C 抑制剂。Ras 蛋白家族是一种重要的细胞内信号分子，在生长发育中起重要作用。KRAS G12C inhibitor 40 具有研究 KRAS G12C 介导的癌症的潜力 (摘自专利 WO2021129824A1，化合物 70)。

KRAS G12C inhibitor 40

KRAS G12C inhibitor 40 Chemical Structure

CAS No. : 2660014-14-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

KRAS G12C inhibitor 40 is a potent inhibitor of KRAS G12C. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12C inhibitor 40 has the potential for the research of KRAS G12C-mediated cancer (extracted from patent WO2021129824A1, compound 70)[1].

分子量

671.17

Formula

C34H36ClFN10O2
CAS 号

2660014-14-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yuli Xie, et al. Novel K-Ras G12C inhibitor. Patent WO2021129824A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务