标签归档：ipivivint

Ipivivint

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Ipivivint 

Ipivivint (compound 38) 是一种有效的 CDC 样激酶 (CLK) 抑制剂，对 CLK2 和 CLK3 的 EC50 分别为 1 nM、7 nM。Ipivivint 抑制 Wnt 通路 (EC50=13 nM)。

Ipivivint

Ipivivint Chemical Structure

CAS No. : 1481617-15-5

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5 mg ￥7800 询问价格 & 货期
10 mg ￥12500 询问价格 & 货期

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生物活性

Ipivivint (compound 38) is a potent CDC-like kinase (CLK) inhibitor with EC50s of 1 nM, 7 nM for CLK2 and CLK3, respectively. Ipivivint inhibits Wnt pathway (EC50=13 nM)[1].

IC50 & Target[1]

CDK2

1 nM (EC50)

CDK3

7 nM (EC50)

Wnt

 

体外研究
(In Vitro)

Western Blot Analysis[1]

Cell Line: SW480 cells
Concentration: 0.01~10 μM
Incubation Time: 1 hour
Result: Potently inhibited SRSF5/6 phosphorylation.

Apoptosis Analysis[1]

Cell Line: SW480 cells
Concentration: 0.01~10 μM
Incubation Time: 0.03 μM~3 μM
Result: Induced apoptosis.

RT-PCR[1]

Cell Line: HEK-293T cells
Concentration: 0.3~3 μM
Incubation Time: 1 hour
Result: Inhibited Wnt/β-catenin signaling induced by Wnt3a.

Immunofluorescence[1]

Cell Line: SW480 cells
Concentration: 0.3~10 μM
Incubation Time: 6 hours
Result: Increased nuclear speckle enlargement.

体内研究
(In Vivo)
Animal Model: Foxn1 mice[1]
Dosage: 25 mg/kg
Administration: P.o.
Result: Potently inhibited tumor SRSF6 phosphorylation.

分子量

464.50

Formula

C26H21FN8
CAS 号

1481617-15-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Betty Tam, et al. Methods of treating cancer using a clk inhibitor. WO2020006115A1.

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