上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Thio-ITP (Synonyms: 6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5′-triphosphate; 6-Thio-ITP)
Thio-ITP (6-Thioinosine 5′-triphosphate) 是一种 RNA 聚合酶 (RNA polymerase) 活性的竞争性抑制剂。Thio-ITP 对聚合酶具有高表观亲和力,RNA 聚合酶 I 的 Ki 值为 40.9 μM,RNA聚合酶 II 的 Ki 值为 38.0 μM。
Thio-ITP Chemical Structure
CAS No. : 27652-34-2
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生物活性 |
Thio-ITP (6-Thioinosine 5′-triphosphate) is an RNA polymerase activity competitive inhibitor. Thio-ITP has a high apparent affinity for the polymerases (RNA polymerase I Ki: 40.9 μM; RNA polymerase II Ki: 38.0 μM)[1]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
Thio-ITP inhibits both endogenous and exogenous DNA-directed RNA synthesis[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
524.23 |
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Formula |
C10H15N4O13P3S |
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CAS 号 |
27652-34-2 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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