标签归档：kt

Cas(126643-37-6), KT5823, KT-5823,KT5823,

发表于由

KT5823,PKG抑制剂

有效的PKG选择性抑制剂
≥97%(HPLC)

有货

Cas(126643-37-6), KT5823, KT-5823,KT5823,

CAS编号 126643-37-6 | 品牌：Jinpan
KT5823

MSDS

质检证书(CoA)

相似产品

  • 分子式 C29H25N3O5
  • 分子量495.5
  • PubChem编号 108152

货号 (SKU) 包装规格 是否现货 价格 数量
K139567-100μg 100μg 现货 Cas(126643-37-6), KT5823, KT-5823,KT5823,  

基本信息

产品名称 KT5823,PKG抑制剂
英文名称 KT5823
别名 KT-5823
英文别名 KT-5823
规格或纯度 ≥97%(HPLC)
运输条件 超低温冰袋运输
生化机理 蛋白激酶G（PKG）的有效，选择性，可逆抑制剂（K i = 234 nM）。K252的衍生物，对PKA和PKC具有选择性（K i值分别> 10和4μM）。防止体内G蛋白信号调节剂的磷酸化增加

一般描述

产品介绍：
KT5823是一种蛋白激酶抑制剂。它可抑制鸟苷一磷酸（GMP）依赖性蛋白激酶活性（cGK）。它是一种星形孢菌素化合物，可促进促甲状腺激素并调节Na+/I−同向转运体(NIS)的表达。
产品用途：
KT 5823已被用作皮质培养物、皮质神经元和小鼠脑毛细血管内皮细胞中环磷酸鸟苷（cGMP）依赖性蛋白激酶（PKG）抑制剂。

KT5823 is a potent, selective inhibitor of cGMP-dependent protein kinase (PKG)
A selective inhibitor of cGKI and spontaneous apoptosis

相关属性

CAS编号 126643-37-6
敏感性 对光线敏感，对湿度敏感
折光率 1.76
沸点 574.2-684.2at 760 mmHg
溶解性 Soluble in water (partly miscible), DMSO (20 mg/ml), DMF (20 mg/ml), and ethyl acetate (5 mg/ml)
储存温度 避光,-20°C储存,充氩
分子量 495.5
分子式 C29H25N3O5
品牌 Jinpan
备注 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
PubChem CID 108152

UG友利格乳胶KT004

发表于由

UG友利格乳胶

  • 产品型号：KT004
  • 简要描述：UG友利格乳胶金畔生物供应：光度计，检测仪，培养基，全系荧光定量PCR耗材，PCR八联管，进口PCR板，移液器吸嘴，离心管，冻存管，培养皿，培养板，培养瓶，吸头，仪器及手套，色谱耗材，针头过滤器。
产品咨询在线客服
  • 产品简介

UG友利格乳胶上海金畔生物科技有限公司供应：光度计，检测仪，培养基仪，移液器，钻石吸嘴，离心管，冻存管，培养皿全系荧光定量PCR耗材，产品包括：PCR单管、PCR八联管、96孔板、384孔板。

代码 名称 规格

KT004 有粉乳胶手套 10盒/箱×100只/盒

(XS,S,M,L) 克重：5g

医用玉米淀粉

KT007 加厚型有粉乳胶手套 10盒/箱×100只/盒

(XS,S,M,L) 克重：5.8g

医用玉米淀粉

KT005 加厚型无粉乳胶手套   （柔软型） 10盒/箱×100只/盒

(XS,S,M,L) 克重：6g

KT006 斗牛犬无粉乳胶手套     (轻氯洗) 10盒/箱×100只/盒

(XS,S,M,L) 克重：5.8g

舒适白（C0930W） 友利格舒适白乳胶检查手套 10盒/箱×100只/盒

(XS,S,M,L) 克重：5.4g

高分子工艺柔软舒适环保

友利格白珍珠   （Z093X） 友利格白珍珠乳胶检查手套 10盒/箱×100只/盒

(XS,S,M,L) 克重：6g

易穿戴柔软舒适环保

友利格雷诺E            绿珍珠乳胶检查手套       （清香薄荷） 10盒/箱×100只/盒

(XS,S,M,L) 克重：5.8g

润肤羊毛脂+维生素E

友利格雷诺E           （独立/灭菌） 白色乳胶检查手套          （有粉）      10盒/箱×100只/盒

(XS,S,M,L) 克重：5.8g

易穿戴柔软舒适耐用

友利格雷诺E              （独立/灭菌） 绿珍珠乳胶检查手套       （清香薄荷） 10盒/箱×100只/盒

(XS,S,M,L) 克重：5.8g

润肤羊毛脂+维生素E

友利格威克灵  威克灵手套                          （乳胶/丁jing） 10盒/箱×100只/盒

(XS,S,M,L) 克重：7.5g

9/12寸净化无尘

UG友利格乳胶

产品优势：金畔生物代理实验室耗材,PCR耗材品种全，可替代仪器原厂耗材，性价比高，质量稳定，对用户可以节省实验成本。
适应客户：医院检验科PCR实验室，中心实验室，肝病中心；第三方检测机构，科研院所，大专院校，制药厂，试剂生产厂家，疾控中心，检验检疫。 

温馨提示：不可用于临床治疗。

Naftopidil dihydrochloride(Synonyms: KT-611 dihydrochloride; BM-15275 dihydrochloride)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Naftopidil dihydrochloride (Synonyms: KT-611 dihydrochloride; BM-15275 dihydrochloride)

Naftopidil dihydrochloride (KT-611 dihydrochloride) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力 Ki 值分别为 3.7 nM、20 nM、1.2 nM，具有抗增殖作用。Naftopidil dihydrochloride 可用于前列腺增生的研究。

Naftopidil dihydrochloride(Synonyms: KT-611 dihydrochloride; BM-15275 dihydrochloride)

Naftopidil dihydrochloride Chemical Structure

CAS No. : 57149-08-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Naftopidil dihydrochloride 的其他形式现货产品:

Naftopidil

生物活性

Naftopidil dihydrochloride (KT-611 dihydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b– and α1d-adrenoceptor subtypes, respectively. Naftopidil dihydrochloride has antiproliferative effects. Naftopidil dihydrochloride can be used for the research of prostate hyperplasia[1][2].

IC50 & Target[1]

Alpha-1A adrenergic receptor

3.7 nM (Ki)

Alpha-1B adrenergic receptor

20 nM (Ki)

Alpha-1D adrenergic receptor

1.2 (Ki)

体外研究
(In Vitro)

Naftopidil dihydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma[2].
Naftopidil dihydrochloride (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC[2].
Naftopidil dihydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: PCa cells, PrSC
Concentration: 10 μM (PCa cells); 0.1 μM, 1 μM, 10 μM (PrSC)
Incubation Time: 3 days
Result: Exhibited growth inhibitory effects on PCa cells and PrSC in dose-dependent manners.

Western Blot Analysis[2]

Cell Line: PCa cells, PrSC
Concentration: 50 μM (E9 cells), 25 μM (PrSC)
Incubation Time: 48 hours
Result: Increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.

体内研究
(In Vivo)

Naftopidil dihydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male athymic mice(7-8 weeks), with E9+PrSC xenograft[2]
Dosage: 10 mg/kg
Administration: Oral administration, daily, for 28 days
Result: Decreased tumor weights.

Clinical Trial

分子量

465.41

Formula

C24H30Cl2N2O3
CAS 号

57149-08-3
中文名称

萘哌地尔双盐酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. R Takei, et al. Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. Jpn J Pharmacol. 1999 Apr;79(4):447-54.

    [2]. Yasuhide Hori, et al. Naftopidil, a selective {alpha}1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Cancer Prev Res (Phila). 2011 Jan;4(1):87-96.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Naftopidil hydrochloride(Synonyms: KT-611 hydrochloride; BM-15275 hydrochloride)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Naftopidil hydrochloride (Synonyms: KT-611 hydrochloride; BM-15275 hydrochloride)

Naftopidil hydrochloride (KT-611 hydrochloride) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力 Ki 值分别为 3.7 nM、20 nM、1.2 nM，具有抗增殖作用。Naftopidil hydrochloride 可用于前列腺增生的研究。

Naftopidil hydrochloride(Synonyms: KT-611 hydrochloride; BM-15275 hydrochloride)

Naftopidil hydrochloride Chemical Structure

CAS No. : 1164469-60-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Naftopidil hydrochloride 的其他形式现货产品:

Naftopidil

生物活性

Naftopidil hydrochloride (KT-611 hydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b– and α1d-adrenoceptor subtypes, respectively. Naftopidil hydrochloride has antiproliferative effects. Naftopidil hydrochloride can be used for the research of prostate hyperplasia[1].

IC50 & Target[1]

Alpha-1A adrenergic receptor

3.7 nM (Ki)

Alpha-1B adrenergic receptor

20 nM (Ki)

Alpha-1D adrenergic receptor

1.2 nM (Ki)

体外研究
(In Vitro)

Naftopidil hydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma[2].
Naftopidil hydrochloride (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC[2].
Naftopidil hydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: PCa cells, PrSC
Concentration: 10 μM (PCa cells); 0.1 μM, 1 μM, 10 μM (PrSC)
Incubation Time: 3 days
Result: Exhibited growth inhibitory effects on PCa cells and PrSC in dose-dependent manners.

Western Blot Analysis[2]

Cell Line: PCa cells, PrSC
Concentration: 50 μM (E9 cells), 25 μM (PrSC)
Incubation Time: 48 hours
Result: Increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.

体内研究
(In Vivo)

Naftopidil hydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male athymic mice(7-8 weeks), with E9+PrSC xenograft[2]
Dosage: 10 mg/kg
Administration: Oral administration, daily, for 28 days
Result: Decreased tumor weights.

Clinical Trial

分子量

428.95

Formula

C24H29ClN2O3
CAS 号

1164469-60-6
中文名称

萘哌地尔盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. R Takei, et al. Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. Jpn J Pharmacol. 1999 Apr;79(4):447-54.

    [2]. Yasuhide Hori, et al. Naftopidil, a selective {alpha}1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Cancer Prev Res (Phila). 2011 Jan;4(1):87-96.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Naftopidil dihydrochloride(Synonyms: KT-611 dihydrochloride; BM-15275 dihydrochloride)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Naftopidil dihydrochloride (Synonyms: KT-611 dihydrochloride; BM-15275 dihydrochloride)

Naftopidil dihydrochloride (KT-611 dihydrochloride) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力 Ki 值分别为 3.7 nM、20 nM、1.2 nM，具有抗增殖作用。Naftopidil dihydrochloride 可用于前列腺增生的研究。

Naftopidil dihydrochloride(Synonyms: KT-611 dihydrochloride; BM-15275 dihydrochloride)

Naftopidil dihydrochloride Chemical Structure

CAS No. : 57149-08-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Naftopidil dihydrochloride 的其他形式现货产品:

Naftopidil

生物活性

Naftopidil dihydrochloride (KT-611 dihydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b– and α1d-adrenoceptor subtypes, respectively. Naftopidil dihydrochloride has antiproliferative effects. Naftopidil dihydrochloride can be used for the research of prostate hyperplasia[1][2].

IC50 & Target[1]

Alpha-1A adrenergic receptor

3.7 nM (Ki)

Alpha-1B adrenergic receptor

20 nM (Ki)

Alpha-1D adrenergic receptor

1.2 (Ki)

体外研究
(In Vitro)

Naftopidil dihydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma[2].
Naftopidil dihydrochloride (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC[2].
Naftopidil dihydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: PCa cells, PrSC
Concentration: 10 μM (PCa cells); 0.1 μM, 1 μM, 10 μM (PrSC)
Incubation Time: 3 days
Result: Exhibited growth inhibitory effects on PCa cells and PrSC in dose-dependent manners.

Western Blot Analysis[2]

Cell Line: PCa cells, PrSC
Concentration: 50 μM (E9 cells), 25 μM (PrSC)
Incubation Time: 48 hours
Result: Increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.

体内研究
(In Vivo)

Naftopidil dihydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male athymic mice(7-8 weeks), with E9+PrSC xenograft[2]
Dosage: 10 mg/kg
Administration: Oral administration, daily, for 28 days
Result: Decreased tumor weights.

Clinical Trial

分子量

465.41

Formula

C24H30Cl2N2O3
CAS 号

57149-08-3
中文名称

萘哌地尔双盐酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. R Takei, et al. Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. Jpn J Pharmacol. 1999 Apr;79(4):447-54.

    [2]. Yasuhide Hori, et al. Naftopidil, a selective {alpha}1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Cancer Prev Res (Phila). 2011 Jan;4(1):87-96.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Naftopidil dihydrochloride(Synonyms: KT-611 dihydrochloride; BM-15275 dihydrochloride)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Naftopidil dihydrochloride (Synonyms: KT-611 dihydrochloride; BM-15275 dihydrochloride)

Naftopidil dihydrochloride (KT-611 dihydrochloride) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力 Ki 值分别为 3.7 nM、20 nM、1.2 nM，具有抗增殖作用。Naftopidil dihydrochloride 可用于前列腺增生的研究。

Naftopidil dihydrochloride(Synonyms: KT-611 dihydrochloride; BM-15275 dihydrochloride)

Naftopidil dihydrochloride Chemical Structure

CAS No. : 57149-08-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Naftopidil dihydrochloride 的其他形式现货产品:

Naftopidil

生物活性

Naftopidil dihydrochloride (KT-611 dihydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b– and α1d-adrenoceptor subtypes, respectively. Naftopidil dihydrochloride has antiproliferative effects. Naftopidil dihydrochloride can be used for the research of prostate hyperplasia[1][2].

IC50 & Target[1]

Alpha-1A adrenergic receptor

3.7 nM (Ki)

Alpha-1B adrenergic receptor

20 nM (Ki)

Alpha-1D adrenergic receptor

1.2 (Ki)

体外研究
(In Vitro)

Naftopidil dihydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma[2].
Naftopidil dihydrochloride (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC[2].
Naftopidil dihydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: PCa cells, PrSC
Concentration: 10 μM (PCa cells); 0.1 μM, 1 μM, 10 μM (PrSC)
Incubation Time: 3 days
Result: Exhibited growth inhibitory effects on PCa cells and PrSC in dose-dependent manners.

Western Blot Analysis[2]

Cell Line: PCa cells, PrSC
Concentration: 50 μM (E9 cells), 25 μM (PrSC)
Incubation Time: 48 hours
Result: Increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.

体内研究
(In Vivo)

Naftopidil dihydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male athymic mice(7-8 weeks), with E9+PrSC xenograft[2]
Dosage: 10 mg/kg
Administration: Oral administration, daily, for 28 days
Result: Decreased tumor weights.

Clinical Trial

分子量

465.41

Formula

C24H30Cl2N2O3
CAS 号

57149-08-3
中文名称

萘哌地尔双盐酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. R Takei, et al. Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. Jpn J Pharmacol. 1999 Apr;79(4):447-54.

    [2]. Yasuhide Hori, et al. Naftopidil, a selective {alpha}1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Cancer Prev Res (Phila). 2011 Jan;4(1):87-96.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Naftopidil hydrochloride(Synonyms: KT-611 hydrochloride; BM-15275 hydrochloride)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Naftopidil hydrochloride (Synonyms: KT-611 hydrochloride; BM-15275 hydrochloride)

Naftopidil hydrochloride (KT-611 hydrochloride) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力 Ki 值分别为 3.7 nM、20 nM、1.2 nM，具有抗增殖作用。Naftopidil hydrochloride 可用于前列腺增生的研究。

Naftopidil hydrochloride(Synonyms: KT-611 hydrochloride; BM-15275 hydrochloride)

Naftopidil hydrochloride Chemical Structure

CAS No. : 1164469-60-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Naftopidil hydrochloride 的其他形式现货产品:

Naftopidil

生物活性

Naftopidil hydrochloride (KT-611 hydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b– and α1d-adrenoceptor subtypes, respectively. Naftopidil hydrochloride has antiproliferative effects. Naftopidil hydrochloride can be used for the research of prostate hyperplasia[1].

IC50 & Target[1]

Alpha-1A adrenergic receptor

3.7 nM (Ki)

Alpha-1B adrenergic receptor

20 nM (Ki)

Alpha-1D adrenergic receptor

1.2 nM (Ki)

体外研究
(In Vitro)

Naftopidil hydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma[2].
Naftopidil hydrochloride (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC[2].
Naftopidil hydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: PCa cells, PrSC
Concentration: 10 μM (PCa cells); 0.1 μM, 1 μM, 10 μM (PrSC)
Incubation Time: 3 days
Result: Exhibited growth inhibitory effects on PCa cells and PrSC in dose-dependent manners.

Western Blot Analysis[2]

Cell Line: PCa cells, PrSC
Concentration: 50 μM (E9 cells), 25 μM (PrSC)
Incubation Time: 48 hours
Result: Increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.

体内研究
(In Vivo)

Naftopidil hydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male athymic mice(7-8 weeks), with E9+PrSC xenograft[2]
Dosage: 10 mg/kg
Administration: Oral administration, daily, for 28 days
Result: Decreased tumor weights.

Clinical Trial

分子量

428.95

Formula

C24H29ClN2O3
CAS 号

1164469-60-6
中文名称

萘哌地尔盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. R Takei, et al. Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. Jpn J Pharmacol. 1999 Apr;79(4):447-54.

    [2]. Yasuhide Hori, et al. Naftopidil, a selective {alpha}1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Cancer Prev Res (Phila). 2011 Jan;4(1):87-96.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Naftopidil hydrochloride(Synonyms: KT-611 hydrochloride; BM-15275 hydrochloride)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Naftopidil hydrochloride (Synonyms: KT-611 hydrochloride; BM-15275 hydrochloride)

Naftopidil hydrochloride (KT-611 hydrochloride) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力 Ki 值分别为 3.7 nM、20 nM、1.2 nM，具有抗增殖作用。Naftopidil hydrochloride 可用于前列腺增生的研究。

Naftopidil hydrochloride(Synonyms: KT-611 hydrochloride; BM-15275 hydrochloride)

Naftopidil hydrochloride Chemical Structure

CAS No. : 1164469-60-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Naftopidil hydrochloride 的其他形式现货产品:

Naftopidil

生物活性

Naftopidil hydrochloride (KT-611 hydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b– and α1d-adrenoceptor subtypes, respectively. Naftopidil hydrochloride has antiproliferative effects. Naftopidil hydrochloride can be used for the research of prostate hyperplasia[1].

IC50 & Target[1]

Alpha-1A adrenergic receptor

3.7 nM (Ki)

Alpha-1B adrenergic receptor

20 nM (Ki)

Alpha-1D adrenergic receptor

1.2 nM (Ki)

体外研究
(In Vitro)

Naftopidil hydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma[2].
Naftopidil hydrochloride (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC[2].
Naftopidil hydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: PCa cells, PrSC
Concentration: 10 μM (PCa cells); 0.1 μM, 1 μM, 10 μM (PrSC)
Incubation Time: 3 days
Result: Exhibited growth inhibitory effects on PCa cells and PrSC in dose-dependent manners.

Western Blot Analysis[2]

Cell Line: PCa cells, PrSC
Concentration: 50 μM (E9 cells), 25 μM (PrSC)
Incubation Time: 48 hours
Result: Increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.

体内研究
(In Vivo)

Naftopidil hydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male athymic mice(7-8 weeks), with E9+PrSC xenograft[2]
Dosage: 10 mg/kg
Administration: Oral administration, daily, for 28 days
Result: Decreased tumor weights.

Clinical Trial

分子量

428.95

Formula

C24H29ClN2O3
CAS 号

1164469-60-6
中文名称

萘哌地尔盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. R Takei, et al. Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. Jpn J Pharmacol. 1999 Apr;79(4):447-54.

    [2]. Yasuhide Hori, et al. Naftopidil, a selective {alpha}1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Cancer Prev Res (Phila). 2011 Jan;4(1):87-96.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务