标签归档：kushenol

Kushenol A(Synonyms: Leachianone E)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Kushenol A (Synonyms: Leachianone E)

Kushenol A (Leachianone E) 从苦参根中分离出来的。Kushenol A 是一种非竞争性酪氨酸酶 (tyrosinase) 抑制剂，可阻止 L-tyrosinase 转化为 L-DOPA，IC50 和 Ki 值分别为 1.1 μM 和 0.4 μM。Kushenol A 是一种类黄酮抗氧化剂，对 α-葡萄糖苷酶 (alpha-glucosidase) (IC50: 45 μM; Ki: 6.8 μM) 和 β-淀粉酶 (beta-amylase) 具有抑制作用。Kushenol A 被认为是化妆品针对皮肤美白和衰老的潜在酶抑制剂。

Kushenol A(Synonyms: Leachianone E)

Kushenol A Chemical Structure

CAS No. : 99217-63-7

规格 价格 是否有货
5 mg ￥8500 询问价格 & 货期
10 mg ￥15000 询问价格 & 货期

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生物活性

Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC50 and Kivalues of 1.1 μM and 0.4 μM, respectively[1]. Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC50: 45 μM; Ki: 6.8 μM) and β-amylase[2]. Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging[1].

IC50 & Target

IC50: 1.1 μM (tyrosinase); 45 μM (alpha-glucosidase)[1][2]
体外研究
(In Vitro)

Kushenol A (25 μM) exhibits a highly potent inhibitory activity on ABTS+ radical scavenging with an IC50 value of 9.7 ± 0.1 μM, and exhibits inhibits scavenging activity as a percentage 93.7% at 25 μM[1].
Kushenol A (0-60 μg/ml; 24 hours) shows considerable cytotoxic effects against NSCLC cells, exhibits IC50 values of 5.3 μg/ml and 20.5 μg/ml for A549 and NCI‐H226 cells, respectively. It shows an IC50 value of 57.2 μg/ml for BEAS-2B cells[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: NSCLC cell lines, A549 and NCI-H226
Normal human lung epithelial: BEAS-2B
Concentration: 0-60 μg/ml
Incubation Time: 24 hours
Result: Exhibited considerable cytotoxic effects against NSCLC cells.

分子量

408.49

Formula

C25H28O5
CAS 号

99217-63-7
中文名称

苦参新醇A
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Kim JH, et al. Kushenol A and 8-prenylkaempferol, tyrosinase inhibitors, derived from Sophora flavescens. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1048-1054.

    [2]. Kim JH, et al. Glycosidase inhibitory flavonoids from Sophora flavescens. Biol Pharm Bull. 2006 Feb;29(2):302-5.

    [3]. Chen H, et al. A Novel Flavonoid Kushenol Z from Sophora flavescens Mediates mTOR Pathway by Inhibiting Phosphodiesterase and Akt Activity to Induce Apoptosis in Non-Small-Cell Lung Cancer Cells.Molecules. 2019 Dec 4;24(24). pii: E4425.

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Kushenol E

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Kushenol E  纯度: ≥96.0%

Kushenol E 是从 Sophora flavescens 中分离出的一类类黄酮，是 IDO1 的非竞争性抑制剂，其 IC50 值为 7.7 µM，Ki 值为 9.5 µM，具有抗肿瘤活性。

Kushenol E

Kushenol E Chemical Structure

CAS No. : 99119-72-9

规格 价格 是否有货 数量
1 mg ￥3500 In-stock
5 mg ￥10500 In-stock
10 mg   询价  
50 mg   询价  

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Kushenol E 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 of 7.7 µM and a Ki of 9.5 µM, has anti-tumor activity[1].

分子量

424.49

Formula

C25H28O6
CAS 号

99119-72-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献

  • [1]. Kwon M, et al. Inhibitory effects of flavonoids isolated from Sophora flavescens on indoleamine 2,3-dioxygenase 1 activity. J Enzyme Inhib Med Chem. 2019 Dec;34(1):1481-1488.

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Sophoraflavanone G(Synonyms: Kushenol F)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Sophoraflavanone G (Synonyms: Kushenol F) 纯度: 98.30%

Sophoraflavanone G (Kushenol F) 是从苦参中提取得到的，具有抗肿瘤和抗炎特性。Sophoraflavanone G (Kushenol F) 通过抑制 MAPK 相关途径诱导 MDA-MB-231 和 HL-60 细胞凋亡 (apoptosis)。

Sophoraflavanone G(Synonyms: Kushenol F)

Sophoraflavanone G Chemical Structure

CAS No. : 97938-30-2

规格 价格 是否有货 数量
5 mg ￥1190 In-stock
10 mg ￥2020 In-stock
20 mg ￥3430 In-stock
50 mg   询价  
100 mg   询价  

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Sophoraflavanone G 相关产品

•相关化合物库:

  • Natural Product Library Plus
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  • Apoptosis Compound Library
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  • Traditional Chinese Medicine Monomer Library
  • Flavonoids Library

生物活性

Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties.  Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways[1][2].

IC50 & Target

IC50: 29.7 μM (MDA-MB-231 cell)[1]
体外研究
(In Vitro)

Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cells in a dose-dependent manner[1].
Sophoraflavanone G (0 -100 μM; 24 hours) induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochrome c from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated “intrinsic” pathway[1]
Sophoraflavanone G (0 -40 μM; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner, with an IC50 value of 29.7 ± 5.2 μM[2]<.br>

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

424.49

Formula

C25H28O6
CAS 号

97938-30-2
中文名称

苦参总黄酮； 苦参酚 F
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 250 mg/mL (588.94 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3558 mL 11.7788 mL 23.5577 mL
5 mM 0.4712 mL 2.3558 mL 4.7115 mL
10 mM 0.2356 mL 1.1779 mL 2.3558 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.90 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.90 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.90 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.90 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Li ZY, et al. Sophoraflavanone G Induces Apoptosis in Human Leukemia Cells and Blocks MAPK Activation.Am J Chin Med. 2016;44(1):165-76.

    [2]. Huang WC, et al. Sophoraflavanone G from Sophora flavescens induces apoptosis in triple-negative breast cancer cells.Phytomedicine. 2019 Aug;61:152852.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务