标签归档：leelamine

Leelamine hydrochloride(Synonyms: 脱氢松香胺盐酸盐)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Leelamine hydrochloride (Synonyms: 脱氢松香胺盐酸盐)

Leelamine hydrochloride 是一种从松树皮中提取的三环二萜分子。Leelamine hydrochloride 是一种大麻素 1 型 (CB1) 激动剂，也是前列腺癌细胞中 SREBP1 调节的脂肪酸/脂质合成的抑制剂，不受雄激素受体状态的影响。Leelamine hydrochloride 抑制调节脂肪酸合成的雄激素受体 (androgen receptor) 的转录活性。

Leelamine hydrochloride(Synonyms: 脱氢松香胺盐酸盐)

Leelamine hydrochloride Chemical Structure

CAS No. : 16496-99-4

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Leelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees[1]. Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor, which is known to regulate fatty acid synthesis[2,3].

IC50 & Target[2]

CB1

 

分子量

321.93

Formula

C20H32ClN
CAS 号

16496-99-4
中文名称

脱氢松香胺盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kuzu OF, et al. Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport. Mol Cancer Ther. 2014 Jul;13(7):1690-703.

    [2]. A.O. Ibegbu, et al. Therapeutic Potentials and uses of Cannabinoid Agonists in Health and Disease Conditions. British Journal of Pharmacology and Toxicology 3(2): 76-88, 2012

    [3]. Singh KB, et al. Leelamine is a Novel Lipogenesis Inhibitor in Prostate Cancer Cells In Vitro and In Vivo. Mol Cancer Ther. 2019 Aug 8.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Leelamine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Leelamine 

Leelamine 是大麻素受体 CB1 和 CB2 的弱激动剂。Leelamine 也可以抑制丙酮酸脱氢酶激酶 (PDK)。Leelamine 具有抗肿瘤活性。

Leelamine

Leelamine Chemical Structure

CAS No. : 1446-61-3

规格 价格 是否有货 数量
500 mg ￥500 In-stock
1 g ￥700 In-stock
5 g   询价  
10 g   询价  

* Please select Quantity before adding items.

Leelamine 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Kinase Inhibitor Library
  • Metabolism/Protease Compound Library
  • Neuronal Signaling Compound Library
  • Anti-Cancer Compound Library
  • Glycolysis Compound Library
  • Anti-Cancer Metabolism Compound Library
  • Mitochondria-Targeted Compound Library
  • Glucose Metabolism Compound Library

生物活性

Leelamine is a weak agonist of cannabinoid receptors CB1 and CB2. Leelamine also inhibits pyruvate dehydrogenase kinases (PDKs). Leelamine exhibits anti-tumor activity[1].

IC50 & Target[1]

CB1

 

CB2

 

分子量

285.47

Formula

C20H31N
CAS 号

1446-61-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Merarchi M, et, al. A Brief Overview of the Antitumoral Actions of Leelamine. Biomedicines. 2019 Jul 19;7(3):53.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Leelamine-d4 hydrochloride

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Leelamine-d4 hydrochloride 

Leelamine-d4 hydrochloride 是 Leelamine hydrochloride 的氘代物。Leelamine hydrochloride 是一种从松树皮中提取的三环二萜分子。Leelamine hydrochloride 是一种大麻素 1 型 (CB1) 激动剂，也是前列腺癌细胞中 SREBP1 调节的脂肪酸/脂质合成的抑制剂，不受雄激素受体状态的影响。Leelamine hydrochloride 抑制调节脂肪酸合成的雄激素受体 (androgen receptor) 的转录活性。

Leelamine-d4 hydrochloride

Leelamine-d4 hydrochloride Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Leelamine-d4 hydrochloride is the deuterium labeled Leelamine hydrochloride. Leelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees[1]. Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor, which is known to regulate fatty acid synthesis[2,3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

325.95

Formula

C20H28D4ClN
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Kuzu OF, et al. Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport. Mol Cancer Ther. 2014 Jul;13(7):1690-703.

    [3]. A.O. Ibegbu, et al. Therapeutic Potentials and uses of Cannabinoid Agonists in Health and Disease Conditions. British Journal of Pharmacology and Toxicology 3(2): 76-88, 2012

    [4]. Singh KB, et al. Leelamine is a Novel Lipogenesis Inhibitor in Prostate Cancer Cells In Vitro and In Vivo. Mol Cancer Ther. 2019 Aug 8.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务