标签归档：levomefolate

Levomefolate calcium(Synonyms: 左旋甲状腺素钙)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Levomefolate calcium (Synonyms: 左旋甲状腺素钙) 纯度: 97.11%

Levomefolate calcium 是叶酸的人造形式，抗叶酸的作用。

Levomefolate calcium(Synonyms: 左旋甲状腺素钙)

Levomefolate calcium Chemical Structure

CAS No. : 151533-22-1

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50 mg ￥650 In-stock
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生物活性

Levomefolate calcium is an artificial form of folate. IC50 Value: Target: Antifolate The calcium salt of L-5-methyltetrahydrofolic acid which belongs to the group of folate vitamins (Vitamin B9, Folacin). It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.

Clinical Trial

分子量

497.52

Formula

C20H23CaN7O6
CAS 号

151533-22-1
中文名称

左旋甲状腺素钙
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : 4.4 mg/mL (8.84 mM; Need ultrasonic and warming)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0100 mL 10.0498 mL 20.0997 mL
5 mM 0.4020 mL 2.0100 mL 4.0199 mL
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Fruzzetti F. Beyaz?: an oral contraceptive fortified with folate. Womens Health (Lond Engl). 2012 Jan;8(1):13-9.

    [2]. Wiesinger H, Eydeler U, Richard F, et al. Bioequivalence evaluation of a folate-supplemented oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium versus ethinylestradiol/drospirenone and levomefolate calcium alone. Clin Drug Investig. 2012 Oct 1;32(10):673-84.

    [3]. Hartmut Blodea, Christine Klippingb, Frank Richardc, et al. Bioequivalence study of an oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium relative to ethinylestradiol/drospirenone and to levomefolate calcium alone. Contraception.2012, 85(2), :177-184

    [4]. Rapkin RB, Creinin MD. The combined oral contraceptive pill containing drospirenone and ethinyl estradiol plus levomefolate calcium. Expert Opin Pharmacother. 2011 Oct;12(15):2403-10. doi: 10.1517/14656566.2011.610791.

    [5]. Levomefolic_acid

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Levomefolate-13C5 calcium(Synonyms: 5-Methyltetrahydrofolic Acid-13C5 calcium salt)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Levomefolate-13C5 calcium (Synonyms: 5-Methyltetrahydrofolic Acid-13C5 calcium salt)

Levomefolate-13C5 calcium 是一种 13C 标记的 Levomefolate (calcium)。Levomefolate calcium 是叶酸的人造形式，抗叶酸的作用。

Levomefolate-13C5 calcium(Synonyms: 5-Methyltetrahydrofolic Acid-13C5 calcium salt)

Levomefolate-13C5 calcium Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Levomefolate-13C5 calcium is the 13C-labeled Levomefolate (calcium). Levomefolate calcium is an artificial form of folate.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

497.44

Formula

C1513C5H18CaN7O6
中文名称

左旋甲状腺素钙 13C5 (钙盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Fruzzetti F. Beyaz?: an oral contraceptive fortified with folate. Womens Health (Lond Engl). 2012 Jan;8(1):13-9.

    [3]. Wiesinger H, Eydeler U, Richard F, et al. Bioequivalence evaluation of a folate-supplemented oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium versus ethinylestradiol/drospirenone and levomefolate calcium alone. Clin Drug Investig. 2012 Oct 1;32(10):673-84.

    [4]. Hartmut Blodea, Christine Klippingb, Frank Richardc, et al. Bioequivalence study of an oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium relative to ethinylestradiol/drospirenone and to levomefolate calcium alone. Contraception.2012, 85(2), :177-184

    [5]. Rapkin RB, Creinin MD. The combined oral contraceptive pill containing drospirenone and ethinyl estradiol plus levomefolate calcium. Expert Opin Pharmacother. 2011 Oct;12(15):2403-10. doi: 10.1517/14656566.2011.610791.

    [6]. Levomefolic_acid

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Levomefolate-13C5 calcium(Synonyms: 5-Methyltetrahydrofolic Acid-13C5 calcium salt)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Levomefolate-13C5 calcium (Synonyms: 5-Methyltetrahydrofolic Acid-13C5 calcium salt)

Levomefolate-13C5 calcium 是一种 13C 标记的 Levomefolate (calcium)。Levomefolate calcium 是叶酸的人造形式，抗叶酸的作用。

Levomefolate-13C5 calcium(Synonyms: 5-Methyltetrahydrofolic Acid-13C5 calcium salt)

Levomefolate-13C5 calcium Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Levomefolate-13C5 calcium is the 13C-labeled Levomefolate (calcium). Levomefolate calcium is an artificial form of folate.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

497.44

Formula

C1513C5H18CaN7O6
中文名称

左旋甲状腺素钙 13C5 (钙盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Fruzzetti F. Beyaz?: an oral contraceptive fortified with folate. Womens Health (Lond Engl). 2012 Jan;8(1):13-9.

    [3]. Wiesinger H, Eydeler U, Richard F, et al. Bioequivalence evaluation of a folate-supplemented oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium versus ethinylestradiol/drospirenone and levomefolate calcium alone. Clin Drug Investig. 2012 Oct 1;32(10):673-84.

    [4]. Hartmut Blodea, Christine Klippingb, Frank Richardc, et al. Bioequivalence study of an oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium relative to ethinylestradiol/drospirenone and to levomefolate calcium alone. Contraception.2012, 85(2), :177-184

    [5]. Rapkin RB, Creinin MD. The combined oral contraceptive pill containing drospirenone and ethinyl estradiol plus levomefolate calcium. Expert Opin Pharmacother. 2011 Oct;12(15):2403-10. doi: 10.1517/14656566.2011.610791.

    [6]. Levomefolic_acid

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Levomefolate-13C5 calcium(Synonyms: 5-Methyltetrahydrofolic Acid-13C5 calcium salt)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Levomefolate-13C5 calcium (Synonyms: 5-Methyltetrahydrofolic Acid-13C5 calcium salt)

Levomefolate-13C5 calcium 是一种 13C 标记的 Levomefolate (calcium)。Levomefolate calcium 是叶酸的人造形式，抗叶酸的作用。

Levomefolate-13C5 calcium(Synonyms: 5-Methyltetrahydrofolic Acid-13C5 calcium salt)

Levomefolate-13C5 calcium Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Levomefolate-13C5 calcium is the 13C-labeled Levomefolate (calcium). Levomefolate calcium is an artificial form of folate.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

497.44

Formula

C1513C5H18CaN7O6
中文名称

左旋甲状腺素钙 13C5 (钙盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Fruzzetti F. Beyaz?: an oral contraceptive fortified with folate. Womens Health (Lond Engl). 2012 Jan;8(1):13-9.

    [3]. Wiesinger H, Eydeler U, Richard F, et al. Bioequivalence evaluation of a folate-supplemented oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium versus ethinylestradiol/drospirenone and levomefolate calcium alone. Clin Drug Investig. 2012 Oct 1;32(10):673-84.

    [4]. Hartmut Blodea, Christine Klippingb, Frank Richardc, et al. Bioequivalence study of an oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium relative to ethinylestradiol/drospirenone and to levomefolate calcium alone. Contraception.2012, 85(2), :177-184

    [5]. Rapkin RB, Creinin MD. The combined oral contraceptive pill containing drospirenone and ethinyl estradiol plus levomefolate calcium. Expert Opin Pharmacother. 2011 Oct;12(15):2403-10. doi: 10.1517/14656566.2011.610791.

    [6]. Levomefolic_acid

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务