标签归档：meisi

MEISi-2

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

MEISi-2  纯度: ≥98.0%

MEISi-2 是一种选择性的 MEIS 抑制剂，MEIS 是造血干细胞 (HSC) 自我更新的关键调控因子。MEISi-2 被开发用于心脏损伤、造血问题、骨髓移植和癌症的研究。

MEISi-2

MEISi-2 Chemical Structure

CAS No. : 2250156-71-7

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10 mg ￥4800 In-stock
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MEISi-2 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus

生物活性

MEISi-2 is a selective inhibitor of MEIS, a key regulator of hematopoietic stem cell (HSC) self-renewal. MEISi-2 is developed for the research of cardiac injuries, hematopoiesis issues, bone marrow transplantations, and cancer[1].

IC50 & Target

MEIS[1]
体外研究
(In Vitro)

MEISi-2 does not significantly inhibit the PBX-Luc-reporter[1].
MEISi-2 induces MEIS dependent hematopoietic stem cell maintenance and self-renewal[1].
MEISi-2 down-regulates MEIS target gene expression[1].
MEISi-2 induces murine (LSKCD34low cells) and human (CD34+, CD133+, and ALDHhi cells) HSC self-renewal ex vivo[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

MEISi-2 (10 µM; i.p.; at day 1, day 4 and day 7) functionally inhibits MEIS in vivo, thus they induces c-Kit+ cell, Sca1+ cell, CD150+ cell, LSK HSPCs, LSKCD34low HSC content and LSKCD150+CD48- HSC content[1].
MEISi-2 down-regulates Meis1 expression, Hif-2α, and key CDKI gene expression including p16, p19, p19ARF[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-6 week-old BALB/c mice[1]
Dosage: 10 µM/100 µL
Administration: Intraperitoneal injection, at day 1, day 4 and day 7
Result: Modulated HSC pool.

分子量

306.32

Formula

C18H14N2O3
CAS 号

2250156-71-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)
参考文献

  • [1]. Raife Dilek Turan, et al. Development of Small Molecule MEIS Inhibitors that modulate HSC activity. Sci Rep. 2020; 10: 7994.

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