标签归档：mer

多肽定制TIP 39 (39 mer), Tuberoinfundibular Neuropeptide 编码 [277302-47-3]

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名称 TIP 39 (39 mer), Tuberoinfundibular Neuropeptide
编码 [277302-47-3]
别名 TIP 39 (39 mer), Tuberoinfundibular Neuropeptide
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） SLALADDAAFRERARLLAALERRHWLNSYMHKLLVLDAP
序列（三字母缩写） H-Ser-Leu-Ala-Leu-Ala-Asp-Asp-Ala-Ala-Phe-Arg-Glu-Arg-Ala-Arg-Leu-Leu-Ala-Ala-Leu-Glu-Arg-Arg-His-Trp-Leu-Asn-Ser-Tyr-Met-His-Lys-Leu-Leu-Val-Leu-Asp-Ala-Pro-OH (trifluoroacetate salt)
基本描述 Tetradecapeptide renin substrate; preangiotensinogen.
溶解度
分子量 4504.3
化学式 C202H325N61O54S1
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents TIP 39 (39 mer), Tuberoinfundibular Neuropeptide 编码 [277302-47-3]
Figures TIP 39 (39 mer), Tuberoinfundibular Neuropeptide 编码 [277302-47-3]
Reference Usdin, TB. et al. Nat. Am. 2, 941 (1999) Piserchio, A. et al. J. Biol. Chem. 275, 27284 (2000).
C端
N端
化学桥

Triparanol(Synonyms: MER-29)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Triparanol (Synonyms: MER-29)

Triparanol (MER-29) 是一种有效的胆固醇生物合成 (cholesterol biosynthesis) 抑制剂，可阻断 24-脱氢胆固醇还原酶(24-DHCR)。Triparanol 可以干扰 Hedgehog 信号分子的翻译后修饰及其受体 PTCH1 的甾醇传感结构域，导致 Hh 信号的下调。Triparanol 抑制人类肿瘤生长。

Triparanol(Synonyms: MER-29)

Triparanol Chemical Structure

CAS No. : 78-41-1

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生物活性

Triparanol (MER-29) is a potent cholesterol biosynthesis inhibitor blocking the 24-dehydrocholesterol reductase (24-DHCR). Triparanol can interfere with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hh signaling. Triparanol suppresses human tumor growth[1][2].

体外研究
(In Vitro)

Triparanol can block proliferation and induce apoptosis in multiple human cancer cells including lung, breast, liver, pancreatic, prostate cancer and melanoma cells, and growth inhibition can be rescued by exogenous addition of cholesterol[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

438.00

Formula

C27H32ClNO2
CAS 号

78-41-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. AVIGAN J, et al. The mechanism of action of MER-29. Prog Cardiovasc Dis. 1960;2:525-530.

    [2]. Bi X, et al. Triparanol suppresses human tumor growth in vitro and in vivo [published correction appears in Biochem Biophys Res Commun. 2012 Nov 2;427(4):808]. Biochem Biophys Res Commun. 2012;425(3):613-618.

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