标签归档：microrna

microRNA-21-IN-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

microRNA-21-IN-1 

microRNA-21-IN-1 (compound 7A) 是一种高效的 microRNA 抑制剂。microRNA-21-IN-1 对 Hela 和 HCT-116 细胞具有抗增殖活性，IC50 分别为 5.5 μM 和 2.8 μM，也能促进 Hela 细胞凋亡 (apoptosis)。microRNA-21-IN-1上调 microRNA-21 下游功能靶点 (PTEN、 EGR1、SLIT2) 的表达。microRNA-21-IN-1 可用于抗癌研究。

microRNA-21-IN-1

microRNA-21-IN-1 Chemical Structure

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生物活性

microRNA-21-IN-1 (compound 7A) is an efficient microRNA inhibitor. microRNA-21-IN-1 has antiproliferative activity against Hela and HCT-116 cells with IC50s of 5.5 μM and 2.8 μM respectively, as well as promotes apoptosis of Hela cells. microRNA-21-IN-1 upregulates the expression of microRNA-21 downstream functional targets (PTEN, EGR1 and SLIT2). microRNA-21-IN-1 can be used for researching anticancer[1].

IC50 & Target

IC50: 5.5 μM in Hela, 2.8 μM in HCT-116[1]
分子量

548.65

Formula

C30H37FN6O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Xi XX, et al. Identification of benzamides derivatives of norfloxacin as promising microRNA-21 inhibitors via repressing its transcription. Bioorg Med Chem. 2022;66:116803.

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