标签归档：nls

NLS (PKKKRKV)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NLS (PKKKRKV) 

NLS (PKKKRKV) 是一种源于 SV40 large T antigen 的 NLS，可作为增强核进入方法应用于基因导入。

NLS (PKKKRKV)

NLS (PKKKRKV) Chemical Structure

CAS No. : 95088-49-6

规格 价格 是否有货
1 mg ￥1000 询问价格 & 货期
5 mg ￥2500 询问价格 & 货期
10 mg ￥4250 询问价格 & 货期

* Please select Quantity before adding items.

NLS (PKKKRKV) 的其他形式现货产品:

NLS (PKKKRKV) (hydrochloride)

生物活性

NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen). NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research[1][2].

分子量

883.14

Formula

C40H78N14O8
CAS 号

95088-49-6
Sequence Shortening

PKKKRKV
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zanta MA, et al. Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):91-6.

    [2]. Cao S, et al. Enhanced effect of nuclear localization signal peptide during ultrasound-targeted microbubble destruction-mediated gene transfection. Mol Med Rep. 2017 Jul;16(1):565-572.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NLS (PKKKRKV) (hydrochloride)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NLS (PKKKRKV) (hydrochloride)  纯度: 98.01%

NLS (PKKKRKV) hydrochloride 是一种源于 SV40 大 T 抗原的 NLS，可作为增强核进入方法应用于基因导入。

NLS (PKKKRKV) (hydrochloride)

NLS (PKKKRKV) (hydrochloride) Chemical Structure

规格 价格 是否有货 数量
5 mg ￥900 In-stock
10 mg ￥1500 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

生物活性

NLS (PKKKRKV) hydrochloride is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen). NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research[1][2].

分子量

919.60

Formula

C40H79ClN14O8
Sequence

Pro-Lys-Lys-Lys-Arg-Lys-Val
Sequence Shortening

PKKKRKV
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro: 

H2O : 500 mg/mL (543.71 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0874 mL 5.4371 mL 10.8743 mL
5 mM 0.2175 mL 1.0874 mL 2.1749 mL
10 mM 0.1087 mL 0.5437 mL 1.0874 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Zanta MA, et al. Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):91-6.

    [2]. Cao S, et al. Enhanced effect of nuclear localization signal peptide during ultrasound-targeted microbubble destruction-mediated gene transfection. Mol Med Rep. 2017 Jul;16(1):565-572.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NLS-StAx-h

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NLS-StAx-h 

NLS-StAx-h 是选择性的 Wnt 信号传导的固定肽抑制剂，IC50 为 1.4 μM。NLS-StAx-h 有效抑制 β-catenin-转录因子的相互作用。NLS-StAx-h 抑制结直肠癌细胞的增殖和迁移。

NLS-StAx-h

NLS-StAx-h Chemical Structure

规格 是否有货
100 μg 询价

* Please select Quantity before adding items.

生物活性

NLS-StAx-h is a selective, stapled peptide inhibitor of Wnt signaling with an IC50 of 1.4 μM. NLS-StAx-h efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h inhibits proliferation and migration of colorectal cancer cells[1].

IC50 & Target[1]

Wnt

1.4 μM (IC50)

体外研究
(In Vitro)

NLS-StAx-h (10 μM, 72 hr) reduces the viability of both SW-480 and DLD-1 by more than 80%. NLS-StAx-h results in gene expression changes[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

3445.26

Formula

C53H100N19O10V2W
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Laura Dietrich, et al. Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling That Targets β-Catenin Protein-Protein Interactions

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NLS-StAx-h

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NLS-StAx-h 

NLS-StAx-h 是选择性的 Wnt 信号传导的固定肽抑制剂，IC50 为 1.4 μM。NLS-StAx-h 有效抑制 β-catenin-转录因子的相互作用。NLS-StAx-h 抑制结直肠癌细胞的增殖和迁移。

NLS-StAx-h

NLS-StAx-h Chemical Structure

规格 是否有货
100 μg 询价

* Please select Quantity before adding items.

生物活性

NLS-StAx-h is a selective, stapled peptide inhibitor of Wnt signaling with an IC50 of 1.4 μM. NLS-StAx-h efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h inhibits proliferation and migration of colorectal cancer cells[1].

IC50 & Target[1]

Wnt

1.4 μM (IC50)

体外研究
(In Vitro)

NLS-StAx-h (10 μM, 72 hr) reduces the viability of both SW-480 and DLD-1 by more than 80%. NLS-StAx-h results in gene expression changes[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

3445.26

Formula

C53H100N19O10V2W
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Laura Dietrich, et al. Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling That Targets β-Catenin Protein-Protein Interactions

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NLS-StAx-h

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NLS-StAx-h 

NLS-StAx-h 是选择性的 Wnt 信号传导的固定肽抑制剂，IC50 为 1.4 μM。NLS-StAx-h 有效抑制 β-catenin-转录因子的相互作用。NLS-StAx-h 抑制结直肠癌细胞的增殖和迁移。

NLS-StAx-h

NLS-StAx-h Chemical Structure

规格 是否有货
100 μg 询价

* Please select Quantity before adding items.

生物活性

NLS-StAx-h is a selective, stapled peptide inhibitor of Wnt signaling with an IC50 of 1.4 μM. NLS-StAx-h efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h inhibits proliferation and migration of colorectal cancer cells[1].

IC50 & Target[1]

Wnt

1.4 μM (IC50)

体外研究
(In Vitro)

NLS-StAx-h (10 μM, 72 hr) reduces the viability of both SW-480 and DLD-1 by more than 80%. NLS-StAx-h results in gene expression changes[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

3445.26

Formula

C53H100N19O10V2W
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Laura Dietrich, et al. Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling That Targets β-Catenin Protein-Protein Interactions

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NLS (PKKKRKV) (TFA)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NLS (PKKKRKV) (TFA) 

NLS (PKKKRKV) TFA 是一种源于 SV40 large T antigen 的 NLS ，可作为增强核进入方法应用于基因导入。

NLS (PKKKRKV) (TFA)

NLS (PKKKRKV) (TFA) Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

NLS (PKKKRKV) (TFA) 的其他形式现货产品:

NLS (PKKKRKV) (hydrochloride)

生物活性

NLS (PKKKRKV) TFA is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen). NLS (PKKKRKV) TFA can function as a method to enhance nuclear entry in the field of gene transfer research[1][2].

体外研究
(In Vitro)

NLS (PKKKRKV) TFA is the minimum nuclear localization signals (NLS) of SV40 T antigen[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

997.16

Formula

C42H79F3N14O10
Sequence Shortening

PKKKRKV
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zanta MA, et al. Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):91-6.

    [2]. Cao S, et al. Enhanced effect of nuclear localization signal peptide during ultrasound-targeted microbubble destruction-mediated gene transfection. Mol Med Rep. 2017 Jul;16(1):565-572.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NLS (PKKKRKV) (TFA)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NLS (PKKKRKV) (TFA) 

NLS (PKKKRKV) TFA 是一种源于 SV40 large T antigen 的 NLS ，可作为增强核进入方法应用于基因导入。

NLS (PKKKRKV) (TFA)

NLS (PKKKRKV) (TFA) Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

NLS (PKKKRKV) (TFA) 的其他形式现货产品:

NLS (PKKKRKV) (hydrochloride)

生物活性

NLS (PKKKRKV) TFA is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen). NLS (PKKKRKV) TFA can function as a method to enhance nuclear entry in the field of gene transfer research[1][2].

体外研究
(In Vitro)

NLS (PKKKRKV) TFA is the minimum nuclear localization signals (NLS) of SV40 T antigen[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

997.16

Formula

C42H79F3N14O10
Sequence Shortening

PKKKRKV
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zanta MA, et al. Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):91-6.

    [2]. Cao S, et al. Enhanced effect of nuclear localization signal peptide during ultrasound-targeted microbubble destruction-mediated gene transfection. Mol Med Rep. 2017 Jul;16(1):565-572.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NLS (PKKKRKV) (TFA)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NLS (PKKKRKV) (TFA) 

NLS (PKKKRKV) TFA 是一种源于 SV40 large T antigen 的 NLS ，可作为增强核进入方法应用于基因导入。

NLS (PKKKRKV) (TFA)

NLS (PKKKRKV) (TFA) Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

NLS (PKKKRKV) (TFA) 的其他形式现货产品:

NLS (PKKKRKV) (hydrochloride)

生物活性

NLS (PKKKRKV) TFA is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen). NLS (PKKKRKV) TFA can function as a method to enhance nuclear entry in the field of gene transfer research[1][2].

体外研究
(In Vitro)

NLS (PKKKRKV) TFA is the minimum nuclear localization signals (NLS) of SV40 T antigen[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

997.16

Formula

C42H79F3N14O10
Sequence Shortening

PKKKRKV
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zanta MA, et al. Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):91-6.

    [2]. Cao S, et al. Enhanced effect of nuclear localization signal peptide during ultrasound-targeted microbubble destruction-mediated gene transfection. Mol Med Rep. 2017 Jul;16(1):565-572.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

多肽定制SV40 NLS; Simian Vacuolating Virus 40 Nuclear Localization Signal 编码

发表于由

上海金畔生物科技有限公司可以定制不同序列多肽，可以访问官网了解更多产品信息。

名称 SV40 NLS; Simian Vacuolating Virus 40 Nuclear Localization Signal
编码
别名 SV40 NLS; Simian Vacuolating Virus 40 Nuclear Localization Signal
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） PKKKRKVG
序列（三字母缩写） Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly
基本描述
溶解度
分子量 940.21
化学式 C42H81N15O9
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents SV40 NLS; Simian Vacuolating Virus 40 Nuclear Localization Signal 编码
Figures SV40 NLS; Simian Vacuolating Virus 40 Nuclear Localization Signal 编码
Reference
C端
N端
化学桥