标签归档：nrx

NRX-252262

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NRX-252262  纯度: 98.97%

NRX-252262 是一种有效的 β-Catenin 与 同源 E3 ligase SCFβ-TrCP 的相互作用增强剂，能够促进 β-catenin 的降解，EC50 值为 3.8 nM。

NRX-252262

NRX-252262 Chemical Structure

CAS No. : 2438637-61-5

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥4199 In-stock
1 mg ￥1800 In-stock
5 mg ￥3500 In-stock
10 mg ￥5500 In-stock
25 mg ￥9900 In-stock
50 mg ￥16500 In-stock
100 mg ￥22500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

NRX-252262 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Stem Cell Signaling Compound Library
  • Wnt/Hedgehog/Notch Compound Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Differentiation Inducing Compound Library
  • Cytoskeleton Compound Library
  • Neuroprotective Compound Library
  • Anti-Breast Cancer Compound Library
  • Transcription Factor Targeted Library
  • Anti-Liver Cancer Compound Library
  • Anti-Colorectal Cancer Compound Library

生物活性

NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM[1].

IC50 & Target

EC50: 3.8 nM (β-Catenin-SCFβ-TrCP)[1]
体外研究
(In Vitro)

NRX-252262 (35 μM) causes S33E/S37A mutant β-catenin degradation in cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

545.36

Formula

C23H17Cl2F3N2O4S
CAS 号

2438637-61-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 8.33 mg/mL (15.27 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8337 mL 9.1683 mL 18.3365 mL
5 mM 0.3667 mL 1.8337 mL 3.6673 mL
10 mM 0.1834 mL 0.9168 mL 1.8337 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Kyle R. Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications. 2019 March.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NRX-1933

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NRX-1933 

NRX-1933 是一种 β-catenin:β-TrCP 相互作用增强剂，用于开发小分子降解物。

NRX-1933

NRX-1933 Chemical Structure

CAS No. : 2763260-30-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

NRX-1933 is a β-catenin:β-TrCP interaction enhancer for the development of small molecule degraders.

分子量

350.26

Formula

C14H9F3N6O2
CAS 号

2763260-30-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Simonetta KR, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NRX-1532

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NRX-1532 

NRX-1532 是一种 β-catenin:β-TrCP 相互作用的小分子增强剂。

NRX-1532

NRX-1532 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

NRX-1532 is a small molecule enhancer of β-catenin:β-TrCP interaction.

分子量

348.28

Formula

C16H11F3N4O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Simonetta KR, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NRX-252114

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NRX-252114 

NRX-252114 是一种有效的 β-catenin 与 同源 E3 ligase SCFβ-TrCP 的相互作用增强剂，增强 pSer33/S37A β-catenin 与 β-TrCP 的结合，EC50 为 6.5 nM，Kd 为 0.4 nM。NRX-252114 能够促进突变体 β-catenin 的降解。

NRX-252114

NRX-252114 Chemical Structure

CAS No. : 2763260-39-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

NRX-252114 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant β-catenin degradation[1].

IC50 & Target

EC50: 6.5 nM (β-catenin:β-TrCP Interaction)[1]
Kd: 0.4 nM (β-catenin:β-TrCP Interaction)[1]
体外研究
(In Vitro)

NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with >1500-fold cooperativity, surpassing the affinity of wild-type doubly-phosphorylated peptide. NRX-252114 further enhances the ubiquitylation of pSer33/S37A β-catenin peptide to form long ubiquitin chains[1].
The non-phosphorylated Ser33/Ser37 peptide binds β-TrCP with very weak affinity (>100 μM); however, in the presence of 20 μM NRX-252114 that binding affinity is enhanced to 180 nM. NRX-252114 also potentiates the ubiquitylation of unphosphorylated Ser33/S37A β-catenin peptides by the SCFβ-TrCP complex[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

510.32

Formula

C22H12Cl2F3N3O2S
CAS 号

2763260-39-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NRX-2663

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NRX-2663 

NRX-2663 是一种 β-catenin 与 同源 E3 ligase SCFβ-TrCP 的相互作用增强剂，增强 β-catenin 与 β-TrCP 的结合，EC50 为 22.9 µM，Kd 为 54.8 nM。

NRX-2663

NRX-2663 Chemical Structure

CAS No. : 2763260-34-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 µM and a Kd of 54.8 nM[1].

IC50 & Target

EC50: 22.9 µM (β-catenin:β-TrCP Interaction)[1]
Kd: 54.8 nM (β-catenin:β-TrCP Interaction)[1]
体外研究
(In Vitro)

NRX-2663 displays both improved potency in the binding assay with pSer33/Ser37 β-catenin (EC50 of 80 µM) and cooperativity of binding (13-fold). NRX-2663 also markedly enhances the ubiquitylation of the pSer33/Ser37 β-catenin peptide, with ubiquitin chain formation at ligand concentrations of 16 μM and above resembling ubiquitin chain formation on wild-type pSer33/pSer37 β-catenin peptide[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

418.32

Formula

C20H13F3N2O5
CAS 号

2763260-34-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NRX-103094

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NRX-103094 

NRX-103094 是一种有效的 β-catenin 与 同源 E3 ligase SCFβ-TrCP 的相互作用增强剂，增强 pSer33/Ser37 β-catenin 与 β-TrCP 的结合，EC50 为 62 nM，Kd 为 0.6 nM。

NRX-103094

NRX-103094 Chemical Structure

CAS No. : 2763260-36-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

NRX-103094 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103094 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM[1].

IC50 & Target

EC50: 62 nM (β-catenin:β-TrCP Interaction)[1]
Kd: 0.6 nM (β-catenin:β-TrCP Interaction)[1]
体外研究
(In Vitro)

NRX-103094 shows high potency with pSer33/Ser37 β-catenin peptide (EC50 of 457 nM). NRX-103094 potentiates the ubiquitylation of pSer33/S37A β-catenin peptide to levels greater than wild-type pSer33/pSer37 levels at 250 nM[1].
NRX-103094 enhances the S33E/S37A phosphomimetic peptide binding affinity for β-TrCP from >5 μM in the absence of compound to 22 nM in the presence of 40 μM compound. In the presence of 20 μM NRX-103094, robust time-dependent ubiquitylation of S33E/S37A β-catenin peptide is observed. Likewise, the full-length S33E/S37A β-catenin protein is strongly ubiquitylated in the presence of 20 μM NRX-103094, with the ubiquitylation levels approaching that of WT full-length β-catenin protein[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

503.28

Formula

C20H11Cl2F3N2O4S
CAS 号

2763260-36-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NRX-103095

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NRX-103095 

NRX-103095 是一种 β-catenin 与 同源 E3 ligase SCFβ-TrCP 的相互作用增强剂，增强 pSer33/Ser37 β-catenin 与 β-TrCP 的结合，EC50 为 163 nM。

NRX-103095

NRX-103095 Chemical Structure

CAS No. : 2763260-38-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

NRX-103095 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103095 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 163 nM[1].

IC50 & Target

EC50: 163 nM (β-catenin:β-TrCP Interaction)[1]
分子量

530.35

Formula

C22H16Cl2F3N3O3S
CAS 号

2763260-38-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NRX-252114

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NRX-252114 

NRX-252114 是一种有效的 β-catenin 与 同源 E3 ligase SCFβ-TrCP 的相互作用增强剂，增强 pSer33/S37A β-catenin 与 β-TrCP 的结合，EC50 为 6.5 nM，Kd 为 0.4 nM。NRX-252114 能够促进突变体 β-catenin 的降解。

NRX-252114

NRX-252114 Chemical Structure

CAS No. : 2763260-39-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

NRX-252114 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant β-catenin degradation[1].

IC50 & Target

EC50: 6.5 nM (β-catenin:β-TrCP Interaction)[1]
Kd: 0.4 nM (β-catenin:β-TrCP Interaction)[1]
体外研究
(In Vitro)

NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with >1500-fold cooperativity, surpassing the affinity of wild-type doubly-phosphorylated peptide. NRX-252114 further enhances the ubiquitylation of pSer33/S37A β-catenin peptide to form long ubiquitin chains[1].
The non-phosphorylated Ser33/Ser37 peptide binds β-TrCP with very weak affinity (>100 μM); however, in the presence of 20 μM NRX-252114 that binding affinity is enhanced to 180 nM. NRX-252114 also potentiates the ubiquitylation of unphosphorylated Ser33/S37A β-catenin peptides by the SCFβ-TrCP complex[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

510.32

Formula

C22H12Cl2F3N3O2S
CAS 号

2763260-39-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NRX-252114

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NRX-252114 

NRX-252114 是一种有效的 β-catenin 与 同源 E3 ligase SCFβ-TrCP 的相互作用增强剂，增强 pSer33/S37A β-catenin 与 β-TrCP 的结合，EC50 为 6.5 nM，Kd 为 0.4 nM。NRX-252114 能够促进突变体 β-catenin 的降解。

NRX-252114

NRX-252114 Chemical Structure

CAS No. : 2763260-39-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

NRX-252114 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant β-catenin degradation[1].

IC50 & Target

EC50: 6.5 nM (β-catenin:β-TrCP Interaction)[1]
Kd: 0.4 nM (β-catenin:β-TrCP Interaction)[1]
体外研究
(In Vitro)

NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with >1500-fold cooperativity, surpassing the affinity of wild-type doubly-phosphorylated peptide. NRX-252114 further enhances the ubiquitylation of pSer33/S37A β-catenin peptide to form long ubiquitin chains[1].
The non-phosphorylated Ser33/Ser37 peptide binds β-TrCP with very weak affinity (>100 μM); however, in the presence of 20 μM NRX-252114 that binding affinity is enhanced to 180 nM. NRX-252114 also potentiates the ubiquitylation of unphosphorylated Ser33/S37A β-catenin peptides by the SCFβ-TrCP complex[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

510.32

Formula

C22H12Cl2F3N3O2S
CAS 号

2763260-39-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NRX-2663

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NRX-2663 

NRX-2663 是一种 β-catenin 与 同源 E3 ligase SCFβ-TrCP 的相互作用增强剂，增强 β-catenin 与 β-TrCP 的结合，EC50 为 22.9 µM，Kd 为 54.8 nM。

NRX-2663

NRX-2663 Chemical Structure

CAS No. : 2763260-34-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 µM and a Kd of 54.8 nM[1].

IC50 & Target

EC50: 22.9 µM (β-catenin:β-TrCP Interaction)[1]
Kd: 54.8 nM (β-catenin:β-TrCP Interaction)[1]
体外研究
(In Vitro)

NRX-2663 displays both improved potency in the binding assay with pSer33/Ser37 β-catenin (EC50 of 80 µM) and cooperativity of binding (13-fold). NRX-2663 also markedly enhances the ubiquitylation of the pSer33/Ser37 β-catenin peptide, with ubiquitin chain formation at ligand concentrations of 16 μM and above resembling ubiquitin chain formation on wild-type pSer33/pSer37 β-catenin peptide[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

418.32

Formula

C20H13F3N2O5
CAS 号

2763260-34-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NRX-2663

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NRX-2663 

NRX-2663 是一种 β-catenin 与 同源 E3 ligase SCFβ-TrCP 的相互作用增强剂，增强 β-catenin 与 β-TrCP 的结合，EC50 为 22.9 µM，Kd 为 54.8 nM。

NRX-2663

NRX-2663 Chemical Structure

CAS No. : 2763260-34-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 µM and a Kd of 54.8 nM[1].

IC50 & Target

EC50: 22.9 µM (β-catenin:β-TrCP Interaction)[1]
Kd: 54.8 nM (β-catenin:β-TrCP Interaction)[1]
体外研究
(In Vitro)

NRX-2663 displays both improved potency in the binding assay with pSer33/Ser37 β-catenin (EC50 of 80 µM) and cooperativity of binding (13-fold). NRX-2663 also markedly enhances the ubiquitylation of the pSer33/Ser37 β-catenin peptide, with ubiquitin chain formation at ligand concentrations of 16 μM and above resembling ubiquitin chain formation on wild-type pSer33/pSer37 β-catenin peptide[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

418.32

Formula

C20H13F3N2O5
CAS 号

2763260-34-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NRX-103094

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NRX-103094 

NRX-103094 是一种有效的 β-catenin 与 同源 E3 ligase SCFβ-TrCP 的相互作用增强剂，增强 pSer33/Ser37 β-catenin 与 β-TrCP 的结合，EC50 为 62 nM，Kd 为 0.6 nM。

NRX-103094

NRX-103094 Chemical Structure

CAS No. : 2763260-36-0

规格 是否有货
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250 mg   询价  
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生物活性

NRX-103094 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103094 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM[1].

IC50 & Target

EC50: 62 nM (β-catenin:β-TrCP Interaction)[1]
Kd: 0.6 nM (β-catenin:β-TrCP Interaction)[1]
体外研究
(In Vitro)

NRX-103094 shows high potency with pSer33/Ser37 β-catenin peptide (EC50 of 457 nM). NRX-103094 potentiates the ubiquitylation of pSer33/S37A β-catenin peptide to levels greater than wild-type pSer33/pSer37 levels at 250 nM[1].
NRX-103094 enhances the S33E/S37A phosphomimetic peptide binding affinity for β-TrCP from >5 μM in the absence of compound to 22 nM in the presence of 40 μM compound. In the presence of 20 μM NRX-103094, robust time-dependent ubiquitylation of S33E/S37A β-catenin peptide is observed. Likewise, the full-length S33E/S37A β-catenin protein is strongly ubiquitylated in the presence of 20 μM NRX-103094, with the ubiquitylation levels approaching that of WT full-length β-catenin protein[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

503.28

Formula

C20H11Cl2F3N2O4S
CAS 号

2763260-36-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NRX-103095

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NRX-103095 

NRX-103095 是一种 β-catenin 与 同源 E3 ligase SCFβ-TrCP 的相互作用增强剂，增强 pSer33/Ser37 β-catenin 与 β-TrCP 的结合，EC50 为 163 nM。

NRX-103095

NRX-103095 Chemical Structure

CAS No. : 2763260-38-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

NRX-103095 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103095 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 163 nM[1].

IC50 & Target

EC50: 163 nM (β-catenin:β-TrCP Interaction)[1]
分子量

530.35

Formula

C22H16Cl2F3N3O3S
CAS 号

2763260-38-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NRX-103095

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NRX-103095 

NRX-103095 是一种 β-catenin 与 同源 E3 ligase SCFβ-TrCP 的相互作用增强剂，增强 pSer33/Ser37 β-catenin 与 β-TrCP 的结合，EC50 为 163 nM。

NRX-103095

NRX-103095 Chemical Structure

CAS No. : 2763260-38-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

NRX-103095 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103095 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 163 nM[1].

IC50 & Target

EC50: 163 nM (β-catenin:β-TrCP Interaction)[1]
分子量

530.35

Formula

C22H16Cl2F3N3O3S
CAS 号

2763260-38-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务