标签归档：pad

PAD2-IN-1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PAD2-IN-1 

PAD2-IN-1，一种基于苯并咪唑的衍生物，是一种有效的选择性蛋白精氨酸脱亚氨酶 2 (PAD2) 抑制剂。PAD2-IN-1 对 PAD2 的选择性优于 PAD4 (95 倍) 和 PAD3 (79 倍)。

PAD2-IN-1

PAD2-IN-1 Chemical Structure

CAS No. : 2095109-82-1

规格 价格 是否有货
5 mg ￥9500 询问价格 & 货期
10 mg ￥16500 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

PAD2-IN-1, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-1 shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold)[1].

IC50 & Target

Protein Arginine Deiminase 2 (PAD2)[1]
体外研究
(In Vitro)

In the target engagement assay, the EC 50 of PAD2-IN-1 (compound 32a) is 8.3 μM in HEK293T/PAD2 cells, the enhanced potency of PAD2-IN-1 overcomes its relatively poor ability to enter cells[1].
PAD2-IN-1 (compound 32a; 1-25 μM) treatment strongly inhibits histone H3 citrullination with an EC 50 of 2.7 μM in HEK293T/PAD2 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

480.53

Formula

C25H29FN6O3
CAS 号

2095109-82-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Aaron Muth, et al. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017 Apr 13;60(7):3198-3211.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PAD2-IN-2

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PAD2-IN-2 

PAD2-IN-2 是一种有效的 PAD2 抑制剂。PAD2-IN-2 进入 HEK293T/PAD2 细胞的 EC50 值为 5.9 μM。PAD2-IN-2 在 HEK293/PAD2 细胞中抑制组蛋白 H3 瓜氨酸化 (EC50=2.1 μM)。PAD2-IN-2 可用于癌症研究。

PAD2-IN-2

PAD2-IN-2 Chemical Structure

CAS No. : 2095107-57-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PAD2-IN-2 is a potent PAD2 inhibitor. PAD2-IN-2 enters the HEK293T/PAD2 cells with an EC50 of 5.9 μM. PAD2-IN-2 inhibits histone H3 citrullination with an EC50 of 2.1 μM in HEK293/PAD2 cells. PAD2-IN-2 can be used for the research of cancer[1].

IC50 & Target[1]

PAD2

 

体外研究
(In Vitro)

PAD2-IN-2 (compound 37a; 25 μM; HEK293T/PAD2 cells) exhibits good potency with >60% occupancy in target engagement assay[1].
PAD2-IN-2 (0, 1, 5, 10, 25μM ; 72 h) enters the HEK293T/PAD2 cells with an EC50 of 5.9 μM[1].
PAD2-IN-2 (0, 1, 5, 10, 25μM, 3 h) inhibits histone H3 citrullination with an EC50 of 2.1 μM in HEK293/PAD2 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

PAD2-IN-2 (AMF30a) protects K. pneumonia pneumonia mice from Imipenem-induced mortality increase[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

466.51

Formula

C24H27FN6O3
CAS 号

2095107-57-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Muth A, et al. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017 Apr 13;60(7):3198-3211.

    [2]. Ye C, et al. Inappropriate use of antibiotics exacerbates inflammation through OMV-induced pyroptosis in MDR Klebsiella pneumoniae infection. Cell Rep. 2021 Sep 21;36(12):109750.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PAD2-IN-2

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PAD2-IN-2 

PAD2-IN-2 是一种有效的 PAD2 抑制剂。PAD2-IN-2 进入 HEK293T/PAD2 细胞的 EC50 值为 5.9 μM。PAD2-IN-2 在 HEK293/PAD2 细胞中抑制组蛋白 H3 瓜氨酸化 (EC50=2.1 μM)。PAD2-IN-2 可用于癌症研究。

PAD2-IN-2

PAD2-IN-2 Chemical Structure

CAS No. : 2095107-57-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PAD2-IN-2 is a potent PAD2 inhibitor. PAD2-IN-2 enters the HEK293T/PAD2 cells with an EC50 of 5.9 μM. PAD2-IN-2 inhibits histone H3 citrullination with an EC50 of 2.1 μM in HEK293/PAD2 cells. PAD2-IN-2 can be used for the research of cancer[1].

IC50 & Target[1]

PAD2

 

体外研究
(In Vitro)

PAD2-IN-2 (compound 37a; 25 μM; HEK293T/PAD2 cells) exhibits good potency with >60% occupancy in target engagement assay[1].
PAD2-IN-2 (0, 1, 5, 10, 25μM ; 72 h) enters the HEK293T/PAD2 cells with an EC50 of 5.9 μM[1].
PAD2-IN-2 (0, 1, 5, 10, 25μM, 3 h) inhibits histone H3 citrullination with an EC50 of 2.1 μM in HEK293/PAD2 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

PAD2-IN-2 (AMF30a) protects K. pneumonia pneumonia mice from Imipenem-induced mortality increase[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

466.51

Formula

C24H27FN6O3
CAS 号

2095107-57-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Muth A, et al. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017 Apr 13;60(7):3198-3211.

    [2]. Ye C, et al. Inappropriate use of antibiotics exacerbates inflammation through OMV-induced pyroptosis in MDR Klebsiella pneumoniae infection. Cell Rep. 2021 Sep 21;36(12):109750.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PAD2-IN-2

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PAD2-IN-2 

PAD2-IN-2 是一种有效的 PAD2 抑制剂。PAD2-IN-2 进入 HEK293T/PAD2 细胞的 EC50 值为 5.9 μM。PAD2-IN-2 在 HEK293/PAD2 细胞中抑制组蛋白 H3 瓜氨酸化 (EC50=2.1 μM)。PAD2-IN-2 可用于癌症研究。

PAD2-IN-2

PAD2-IN-2 Chemical Structure

CAS No. : 2095107-57-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PAD2-IN-2 is a potent PAD2 inhibitor. PAD2-IN-2 enters the HEK293T/PAD2 cells with an EC50 of 5.9 μM. PAD2-IN-2 inhibits histone H3 citrullination with an EC50 of 2.1 μM in HEK293/PAD2 cells. PAD2-IN-2 can be used for the research of cancer[1].

IC50 & Target[1]

PAD2

 

体外研究
(In Vitro)

PAD2-IN-2 (compound 37a; 25 μM; HEK293T/PAD2 cells) exhibits good potency with >60% occupancy in target engagement assay[1].
PAD2-IN-2 (0, 1, 5, 10, 25μM ; 72 h) enters the HEK293T/PAD2 cells with an EC50 of 5.9 μM[1].
PAD2-IN-2 (0, 1, 5, 10, 25μM, 3 h) inhibits histone H3 citrullination with an EC50 of 2.1 μM in HEK293/PAD2 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

PAD2-IN-2 (AMF30a) protects K. pneumonia pneumonia mice from Imipenem-induced mortality increase[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

466.51

Formula

C24H27FN6O3
CAS 号

2095107-57-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Muth A, et al. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017 Apr 13;60(7):3198-3211.

    [2]. Ye C, et al. Inappropriate use of antibiotics exacerbates inflammation through OMV-induced pyroptosis in MDR Klebsiella pneumoniae infection. Cell Rep. 2021 Sep 21;36(12):109750.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务