标签归档：pdp

PDP-Pfp

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PDP-Pfp  纯度: 98.66%

PDP-Pfp 是一种可还原的 ADC Linker，用于靶向 TM4SF1 细胞外环 1 (ECL1) 的药物。

PDP-Pfp

PDP-Pfp Chemical Structure

CAS No. : 160580-70-1

规格 价格 是否有货
500 mg ￥6900 询问价格 & 货期
1 g ￥11490 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

PDP-Pfp is a reducible ADC linker used for the agents that target for the extracellular loop 1 (ECL1) of TM4SF1 (transmembrane 4 L6 family member 1)[1].

分子量

381.34

Formula

C14H8F5NO2S2
CAS 号

160580-70-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (262.23 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6223 mL 13.1117 mL 26.2233 mL
5 mM 0.5245 mL 2.6223 mL 5.2447 mL
10 mM 0.2622 mL 1.3112 mL 2.6223 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.56 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.56 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.56 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.56 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Fang J,New target for treating cancer. WO2019015696A2.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PDP-C1-Ph-Val-Cit

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PDP-C1-Ph-Val-Cit 

PDP-C1-Ph-Val-Cit 是一种可降解 (cleavable) 的 ADC linker，可用于合成抗体偶联药物 (ADC)。

PDP-C1-Ph-Val-Cit

PDP-C1-Ph-Val-Cit Chemical Structure

CAS No. : 1610769-13-5

规格 价格 是否有货
100 mg ￥10340 询问价格 & 货期
500 mg ￥29890 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

PDP-C1-Ph-Val-Cit is a cleavable ADC linker used for antibody-drug conjugates (ADCs).

IC50 & Target

Cleavable

 

分子量

591.75

Formula

C26H37N7O5S2
CAS 号

1610769-13-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

DSPE-PEG-PDP Cat. No. PG2-DSPD-5k 5000 Da 100 mg修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DSPE-PEG-PDP

Cat. No. PG2-DSPD-5k DSPE-PEG-PDP Cat. No. PG2-DSPD-5k 5000 Da 100 mg
Specification 5000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine (DSPE) and PDP conjugated Polyethylene Glycol is a heterobifunctional PEG derivative that can undergo reaction with sulfhydryl group. DSPE PEG is an 18 carbon phospholipid PEG conjugate which has both hydrophilicity and hydrophobility. PDP (pyridyldithiol propionate) is reactive toward free thiol group to form cleavable disulfide bond. Pegylated phospholipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. Pegylation of phospholipids significantly improves the blood circulation time and stability for encapsulated drugs. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in warm aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Related Products
PG2-DSML-20k , DSPE PEG Maleimide, DSPE-PEG-MAL
PG2-AMDS-5k , DSPE PEG Amine, DSPE-PEG-NH2

DSPE-PEG-PDP Cat. No. PG2-DSPD-3k 3400 Da 100 mg修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DSPE-PEG-PDP

Cat. No. PG2-DSPD-3k DSPE-PEG-PDP Cat. No. PG2-DSPD-3k 3400 Da 100 mg
Specification 3400 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine (DSPE) and PDP conjugated Polyethylene Glycol is a heterobifunctional PEG derivative that can undergo reaction with sulfhydryl group. DSPE PEG is an 18 carbon phospholipid PEG conjugate which has both hydrophilicity and hydrophobility. PDP (pyridyldithiol propionate) is reactive toward free thiol group to form cleavable disulfide bond. Pegylated phospholipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. Pegylation of phospholipids significantly improves the blood circulation time and stability for encapsulated drugs. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in warm aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

DSPE-PEG-PDP Cat. No. PG2-DSPD-2k 2000 Da 100 mg修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DSPE-PEG-PDP

Cat. No. PG2-DSPD-2k DSPE-PEG-PDP Cat. No. PG2-DSPD-2k 2000 Da 100 mg
Specification 2000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine (DSPE) and PDP conjugated Polyethylene Glycol is a heterobifunctional PEG derivative that can undergo reaction with sulfhydryl group. DSPE PEG is an 18 carbon phospholipid PEG conjugate which has both hydrophilicity and hydrophobility. PDP (pyridyldithiol propionate) is reactive toward free thiol group to form cleavable disulfide bond. Pegylated phospholipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. Pegylation of phospholipids significantly improves the blood circulation time and stability for encapsulated drugs. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in warm aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Related Products
PG2-DSML-2k , DSPE PEG Maleimide, DSPE-PEG-MAL

DSPE-PEG-PDP Cat. No. PG2-DSPD-10k 10000 Da 100 mg修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DSPE-PEG-PDP

Cat. No. PG2-DSPD-10k DSPE-PEG-PDP Cat. No. PG2-DSPD-10k 10000 Da 100 mg
Specification 10000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine (DSPE) and PDP conjugated Polyethylene Glycol is a heterobifunctional PEG derivative that can undergo reaction with sulfhydryl group. DSPE PEG is an 18 carbon phospholipid PEG conjugate which has both hydrophilicity and hydrophobility. PDP (pyridyldithiol propionate) is reactive toward free thiol group to form cleavable disulfide bond. Pegylated phospholipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. Pegylation of phospholipids significantly improves the blood circulation time and stability for encapsulated drugs. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in warm aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

OPSS-PEG-OPSS, PDP-PEG-PDP Cat. No. PG2-OS-5k 5000 Da 100 mg修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

OPSS-PEG-OPSS, PDP-PEG-PDP

Cat. No. PG2-OS-5k OPSS-PEG-OPSS, PDP-PEG-PDP Cat. No. PG2-OS-5k 5000 Da 100 mg
Specification 5000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Ortho-pyridyl disulfide (OPSS) functionalized polyethylene glycol (OPSS PEG) is a thiol (-SH) group reactive PEG derivative that can be used to modify biomolecules or other materials via their available thiol groups. Ortho-pyridyl disulfide reacts with thiol group to form a stable disulfide bond while a thiol pyridyl group is released.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

OPSS-PEG-OPSS, PDP-PEG-PDP Cat. No. PG2-OS-3k 3400 Da 100 mg修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

OPSS-PEG-OPSS, PDP-PEG-PDP

Cat. No. PG2-OS-3k OPSS-PEG-OPSS, PDP-PEG-PDP Cat. No. PG2-OS-3k 3400 Da 100 mg
Specification 3400 Da
Unit Size 100 mg
Price $325.00

Qty Add to Cart

Description:

Ortho-pyridyl disulfide (OPSS) functionalized polyethylene glycol (OPSS PEG) is a thiol (-SH) group reactive PEG derivative that can be used to modify biomolecules or other materials via their available thiol groups. Ortho-pyridyl disulfide reacts with thiol group to form a stable disulfide bond while a thiol pyridyl group is released.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

OPSS-PEG-OPSS, PDP-PEG-PDP Cat. No. PG2-OS-2k 2000 Da 100 mg修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

OPSS-PEG-OPSS, PDP-PEG-PDP

Cat. No. PG2-OS-2k OPSS-PEG-OPSS, PDP-PEG-PDP Cat. No. PG2-OS-2k 2000 Da 100 mg
Specification 2000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Ortho-pyridyl disulfide (OPSS) functionalized polyethylene glycol (OPSS PEG) is a thiol (-SH) group reactive PEG derivative that can be used to modify biomolecules or other materials via their available thiol groups. Ortho-pyridyl disulfide reacts with thiol group to form a stable disulfide bond while a thiol pyridyl group is released.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

OPSS-PEG-OPSS, PDP-PEG-PDP Cat. No. PG2-OS-10k 10000 Da 100 mg修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

OPSS-PEG-OPSS, PDP-PEG-PDP

Cat. No. PG2-OS-10k OPSS-PEG-OPSS, PDP-PEG-PDP Cat. No. PG2-OS-10k 10000 Da 100 mg
Specification 10000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Ortho-pyridyl disulfide (OPSS) functionalized polyethylene glycol (OPSS PEG) is a thiol (-SH) group reactive PEG derivative that can be used to modify biomolecules or other materials via their available thiol groups. Ortho-pyridyl disulfide reacts with thiol group to form a stable disulfide bond while a thiol pyridyl group is released.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet