标签归档：plumbagin

Plumbagin(Synonyms: 白花丹素; 2-Methyljuglone)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Plumbagin (Synonyms: 白花丹素; 2-Methyljuglone) 纯度: 99.65%

Plumbagin (2-Methyljuglone) 是从 Plumbago zeylanica L 中得到的萘醌类物质，具有抗肿瘤、抗增殖活性。

Plumbagin(Synonyms: 白花丹素; 2-Methyljuglone)

Plumbagin Chemical Structure

CAS No. : 481-42-5

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥1045 In-stock
50 mg ￥950 In-stock
100 mg   询价  
200 mg   询价  

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生物活性

Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica L, exhibits anticancer and antiproliferative activities[1].

体外研究
(In Vitro)

Plumbagin (0, 5, 10, and 15 μM) induces apoptosis of prostate cancer cell lines, such as DU145, CWR22rv1 and LNCaP, in a dose-dependent manner[1].
Plumbagin (5, 20 μM) obviously inhibits the invasion of PC3, DU145, and CWR22rv1 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: DU145, CWR22rv1, LNCaP and RWPE-1 cells
Concentration: 0, 5, 10, and 15 μM
Incubation Time: 24 hours
Result: Dose-dependently induced apoptosis of DU145, CWR22rv1 and LNCaP, but showed no effect on RWPE-1 cells at up to 20 μM.

体内研究
(In Vivo)

Plumbagin (2 mg/kg, i.p., five days a week for 11 weeks) inhibits the growth of tumor in male athymic nude mice[1].
Plumbagin (2 mg/kg, i.p., five days a week for 11 weeks) inhibits expression of PKCε, suppresses JAK-2 and Stat3 phosphorylation, and activates Stat3, PCNA, VEGF and MMP-9 in mice[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male athymic nude mice bearing DU145 cells[1]
Dosage: 2 mg/kg
Administration: I.P. after 3 days post cell implantation, five days a week.
Result: Delayed tumor growth by 3 weeks, and reduced tumor weight and volume in mice.

分子量

188.18

Formula

C11H8O3
CAS 号

481-42-5
中文名称

白花丹素；白花丹醌
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 150 mg/mL (797.11 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.3141 mL 26.5703 mL 53.1406 mL
5 mM 1.0628 mL 5.3141 mL 10.6281 mL
10 mM 0.5314 mL 2.6570 mL 5.3141 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (11.05 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (11.05 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (11.05 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (11.05 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Aziz MH, et al. Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer. Cancer Res. 2008 Nov 1;68(21):9024-32.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Plumbagin-d3(Synonyms: 2-Methyljuglone-d3)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Plumbagin-d3 (Synonyms: 2-Methyljuglone-d3)

Plumbagin-d3 (2-Methyljuglone-d3) 是 Plumbagin 的氘代物。Plumbagin (2-Methyljuglone) 是从 Plumbago zeylanica L 中得到的萘醌类物质，具有抗肿瘤、抗增殖活性。

Plumbagin-d3(Synonyms: 2-Methyljuglone-d3)

Plumbagin-d3 Chemical Structure

CAS No. : 2733215-81-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Plumbagin-d3 (2-Methyljuglone-d3) is the deuterium labeled Plumbagin. Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica L, exhibits anticancer and antiproliferative activities[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

191.20

Formula

C11H5D3O3
CAS 号

2733215-81-9
中文名称

白花丹素 d3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Aziz MH, et al. Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer. Cancer Res. 2008 Nov 1;68(21):9024-32.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Plumbagin-d3(Synonyms: 2-Methyljuglone-d3)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Plumbagin-d3 (Synonyms: 2-Methyljuglone-d3)

Plumbagin-d3 (2-Methyljuglone-d3) 是 Plumbagin 的氘代物。Plumbagin (2-Methyljuglone) 是从 Plumbago zeylanica L 中得到的萘醌类物质，具有抗肿瘤、抗增殖活性。

Plumbagin-d3(Synonyms: 2-Methyljuglone-d3)

Plumbagin-d3 Chemical Structure

CAS No. : 2733215-81-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Plumbagin-d3 (2-Methyljuglone-d3) is the deuterium labeled Plumbagin. Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica L, exhibits anticancer and antiproliferative activities[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

191.20

Formula

C11H5D3O3
CAS 号

2733215-81-9
中文名称

白花丹素 d3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Aziz MH, et al. Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer. Cancer Res. 2008 Nov 1;68(21):9024-32.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Plumbagin-d3(Synonyms: 2-Methyljuglone-d3)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Plumbagin-d3 (Synonyms: 2-Methyljuglone-d3)

Plumbagin-d3 (2-Methyljuglone-d3) 是 Plumbagin 的氘代物。Plumbagin (2-Methyljuglone) 是从 Plumbago zeylanica L 中得到的萘醌类物质，具有抗肿瘤、抗增殖活性。

Plumbagin-d3(Synonyms: 2-Methyljuglone-d3)

Plumbagin-d3 Chemical Structure

CAS No. : 2733215-81-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Plumbagin-d3 (2-Methyljuglone-d3) is the deuterium labeled Plumbagin. Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica L, exhibits anticancer and antiproliferative activities[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

191.20

Formula

C11H5D3O3
CAS 号

2733215-81-9
中文名称

白花丹素 d3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Aziz MH, et al. Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer. Cancer Res. 2008 Nov 1;68(21):9024-32.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务