标签归档：propafenone

Propafenone(Synonyms: SA-79)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Propafenone (Synonyms: SA-79)

Propafenone (SA-79) 是一种钠通道 (sodium-channel) 阻滞剂，具有抗心律失常的作用。Propafenone 对 β 受体也具有高亲和力 (IC50=32 nM)。Propafenone 阻断瞬时外向钾电流 (Ito) 和持续延迟整流器 K+ 电流 (Isus)，IC50 值分别为 4.9 μM 和 8.6 μM。Propafenone 通过诱导线粒体功能障碍和诱导细胞凋亡 (apoptosis) 抑制食管癌增殖。

Propafenone(Synonyms: SA-79)

Propafenone Chemical Structure

CAS No. : 54063-53-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Propafenone 的其他形式现货产品:

Propafenone hydrochloride (S)-Propafenone

生物活性

Propafenone (SA-79), a sodium-channel blocker, acts an antiarrhythmic agent. Propafenone also has high affinity for the β receptor (IC50=32 nM)[1]. Propafenone blocks the transient outward current (Ito) and the sustained delayed rectifier K current (Isus) with IC50 values of 4.9 μm and 8.6 μm, respectively[2]. Propafenone suppresses esophageal cancer proliferation through inducing mitochondrial dysfunction and induce apoptosis[3].

体外研究
(In Vitro)

Propafenone (5-25 μM) inhibits esophageal squamous cell carcinoma (ESCC) cell proliferation[3].
Propafenone causes mitochondrial dysfunction by a decreased mitochondrial membrane potential and reduced expression of Bcl-xL and Bcl-2[3].
Propafenone (10 and 20 μm) treatment significantly down regulates the expression levels of the anti-apoptotic proteins Bcl-xL and Bcl-2 in ESCC cells. Propafenone also reduces expression of p-ERK[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: The human ESCC cell lines KYSE30, KYSE150 and KYSE270
Concentration: 5, 10, 15, 20, and 25 μm
Incubation Time: 24, 48, and 72 hours
Result: Gradually decreased cell proliferation over time and potently inhibited cell proliferation with increasing concentrations in KYSE30, KYSE150 and KYSE270 cells.

Western Blot Analysis[3]

Cell Line: The human ESCC cell lines KYSE30, KYSE150 and KYSE270
Concentration: 0, 10, and 20 μm
Incubation Time: 72 hours
Result: Significant downregulation of Bcl-xL and Bcl-2 expression levels was observed.

体内研究
(In Vivo)

Propafenone (20 mg/kg; intraperitoneal injection every other day) markedly suppresses the tumor burden with a decrease of 69.2%[3].
Propafenone also significantly inhibits tumor cell proliferation (mean index decreased from 56.3±6.7% in the DMSO-treated group to 20.7±5.1% in the 10 mg/kg propafenone-treated group and 11.3±4.0% in the 20 mg/kg propafenone-treated group)[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice bearing KYSE270-derived xenografts (6-8 weeks)[3]
Dosage: 10 mg/kg or 20 mg/kg
Administration: Intraperitoneally injected
Result: Exerted a significantly inhibitory effect on the growth of tumor xenografts.

分子量

341.44

Formula

C21H27NO3
CAS 号

54063-53-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. J T Lee, et al. The role of genetically determined polymorphic drug metabolism in the beta-blockade produced by propafenone. N Engl J Med. 1990 Jun 21;322(25):1764-8.

    [2]. A Seki, et al. Effects of propafenone on K currents in human atrial myocytes. Br J Pharmacol. 1999 Mar;126(5):1153-62.

    [3]. Wei-Bin Zheng, et al. Propafenone suppresses esophageal cancer proliferation through inducing mitochondrial dysfunction. Am J Cancer Res. 2017 Nov 1;7(11):2245-2256.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Propafenone(Synonyms: SA-79)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Propafenone (Synonyms: SA-79)

Propafenone (SA-79) 是一种钠通道 (sodium-channel) 阻滞剂，具有抗心律失常的作用。Propafenone 对 β 受体也具有高亲和力 (IC50=32 nM)。Propafenone 阻断瞬时外向钾电流 (Ito) 和持续延迟整流器 K+ 电流 (Isus)，IC50 值分别为 4.9 μM 和 8.6 μM。Propafenone 通过诱导线粒体功能障碍和诱导细胞凋亡 (apoptosis) 抑制食管癌增殖。

Propafenone(Synonyms: SA-79)

Propafenone Chemical Structure

CAS No. : 54063-53-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Propafenone 的其他形式现货产品:

Propafenone hydrochloride (S)-Propafenone

生物活性

Propafenone (SA-79), a sodium-channel blocker, acts an antiarrhythmic agent. Propafenone also has high affinity for the β receptor (IC50=32 nM)[1]. Propafenone blocks the transient outward current (Ito) and the sustained delayed rectifier K current (Isus) with IC50 values of 4.9 μm and 8.6 μm, respectively[2]. Propafenone suppresses esophageal cancer proliferation through inducing mitochondrial dysfunction and induce apoptosis[3].

体外研究
(In Vitro)

Propafenone (5-25 μM) inhibits esophageal squamous cell carcinoma (ESCC) cell proliferation[3].
Propafenone causes mitochondrial dysfunction by a decreased mitochondrial membrane potential and reduced expression of Bcl-xL and Bcl-2[3].
Propafenone (10 and 20 μm) treatment significantly down regulates the expression levels of the anti-apoptotic proteins Bcl-xL and Bcl-2 in ESCC cells. Propafenone also reduces expression of p-ERK[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: The human ESCC cell lines KYSE30, KYSE150 and KYSE270
Concentration: 5, 10, 15, 20, and 25 μm
Incubation Time: 24, 48, and 72 hours
Result: Gradually decreased cell proliferation over time and potently inhibited cell proliferation with increasing concentrations in KYSE30, KYSE150 and KYSE270 cells.

Western Blot Analysis[3]

Cell Line: The human ESCC cell lines KYSE30, KYSE150 and KYSE270
Concentration: 0, 10, and 20 μm
Incubation Time: 72 hours
Result: Significant downregulation of Bcl-xL and Bcl-2 expression levels was observed.

体内研究
(In Vivo)

Propafenone (20 mg/kg; intraperitoneal injection every other day) markedly suppresses the tumor burden with a decrease of 69.2%[3].
Propafenone also significantly inhibits tumor cell proliferation (mean index decreased from 56.3±6.7% in the DMSO-treated group to 20.7±5.1% in the 10 mg/kg propafenone-treated group and 11.3±4.0% in the 20 mg/kg propafenone-treated group)[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice bearing KYSE270-derived xenografts (6-8 weeks)[3]
Dosage: 10 mg/kg or 20 mg/kg
Administration: Intraperitoneally injected
Result: Exerted a significantly inhibitory effect on the growth of tumor xenografts.

分子量

341.44

Formula

C21H27NO3
CAS 号

54063-53-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. J T Lee, et al. The role of genetically determined polymorphic drug metabolism in the beta-blockade produced by propafenone. N Engl J Med. 1990 Jun 21;322(25):1764-8.

    [2]. A Seki, et al. Effects of propafenone on K currents in human atrial myocytes. Br J Pharmacol. 1999 Mar;126(5):1153-62.

    [3]. Wei-Bin Zheng, et al. Propafenone suppresses esophageal cancer proliferation through inducing mitochondrial dysfunction. Am J Cancer Res. 2017 Nov 1;7(11):2245-2256.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Propafenone(Synonyms: SA-79)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Propafenone (Synonyms: SA-79)

Propafenone (SA-79) 是一种钠通道 (sodium-channel) 阻滞剂，具有抗心律失常的作用。Propafenone 对 β 受体也具有高亲和力 (IC50=32 nM)。Propafenone 阻断瞬时外向钾电流 (Ito) 和持续延迟整流器 K+ 电流 (Isus)，IC50 值分别为 4.9 μM 和 8.6 μM。Propafenone 通过诱导线粒体功能障碍和诱导细胞凋亡 (apoptosis) 抑制食管癌增殖。

Propafenone(Synonyms: SA-79)

Propafenone Chemical Structure

CAS No. : 54063-53-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Propafenone 的其他形式现货产品:

Propafenone hydrochloride (S)-Propafenone

生物活性

Propafenone (SA-79), a sodium-channel blocker, acts an antiarrhythmic agent. Propafenone also has high affinity for the β receptor (IC50=32 nM)[1]. Propafenone blocks the transient outward current (Ito) and the sustained delayed rectifier K current (Isus) with IC50 values of 4.9 μm and 8.6 μm, respectively[2]. Propafenone suppresses esophageal cancer proliferation through inducing mitochondrial dysfunction and induce apoptosis[3].

体外研究
(In Vitro)

Propafenone (5-25 μM) inhibits esophageal squamous cell carcinoma (ESCC) cell proliferation[3].
Propafenone causes mitochondrial dysfunction by a decreased mitochondrial membrane potential and reduced expression of Bcl-xL and Bcl-2[3].
Propafenone (10 and 20 μm) treatment significantly down regulates the expression levels of the anti-apoptotic proteins Bcl-xL and Bcl-2 in ESCC cells. Propafenone also reduces expression of p-ERK[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: The human ESCC cell lines KYSE30, KYSE150 and KYSE270
Concentration: 5, 10, 15, 20, and 25 μm
Incubation Time: 24, 48, and 72 hours
Result: Gradually decreased cell proliferation over time and potently inhibited cell proliferation with increasing concentrations in KYSE30, KYSE150 and KYSE270 cells.

Western Blot Analysis[3]

Cell Line: The human ESCC cell lines KYSE30, KYSE150 and KYSE270
Concentration: 0, 10, and 20 μm
Incubation Time: 72 hours
Result: Significant downregulation of Bcl-xL and Bcl-2 expression levels was observed.

体内研究
(In Vivo)

Propafenone (20 mg/kg; intraperitoneal injection every other day) markedly suppresses the tumor burden with a decrease of 69.2%[3].
Propafenone also significantly inhibits tumor cell proliferation (mean index decreased from 56.3±6.7% in the DMSO-treated group to 20.7±5.1% in the 10 mg/kg propafenone-treated group and 11.3±4.0% in the 20 mg/kg propafenone-treated group)[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice bearing KYSE270-derived xenografts (6-8 weeks)[3]
Dosage: 10 mg/kg or 20 mg/kg
Administration: Intraperitoneally injected
Result: Exerted a significantly inhibitory effect on the growth of tumor xenografts.

分子量

341.44

Formula

C21H27NO3
CAS 号

54063-53-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. J T Lee, et al. The role of genetically determined polymorphic drug metabolism in the beta-blockade produced by propafenone. N Engl J Med. 1990 Jun 21;322(25):1764-8.

    [2]. A Seki, et al. Effects of propafenone on K currents in human atrial myocytes. Br J Pharmacol. 1999 Mar;126(5):1153-62.

    [3]. Wei-Bin Zheng, et al. Propafenone suppresses esophageal cancer proliferation through inducing mitochondrial dysfunction. Am J Cancer Res. 2017 Nov 1;7(11):2245-2256.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务