标签归档：pyoluteorin

Pyoluteorin(Synonyms: 藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素)

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pyoluteorin (Synonyms: 藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素)

Pyoluteorin 是一种抗生素 (antibiotic)，可抑制 Oomycete fungi，包括植物病原体 Oomycete fungi，并抑制由该真菌引起的植物病害。 Pyoluteorin 在体外诱导人三阴性乳腺癌 MDA-MB-231 细胞凋亡 (apoptosis)。 Pyoluteorin 可用于人类三阴性乳腺癌的研究。

Pyoluteorin(Synonyms: 藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素)

Pyoluteorin Chemical Structure

CAS No. : 25683-07-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses plant diseases caused by this fungus[1]. Pyoluteorin induces human triple-negative breast cancer MDA-MB-231 cells apoptosis in vitro. Pyoluteorin can be used for the research of human triple-negative breast cancer[2].

体外研究
(In Vitro)

Pyoluteorin is an antifungal compound composed of a bichlorinated pyrrole linked to a resorcinol moiety, were identified within a 24-kb genomic region of Pseudomonas fluorescens Pf-5[1].
Pyoluteorin has significant cytotoxicity towards MCF-7 (IC50=1.84 μM). Pyoluteorin also displays significantly selective cytotoxicity against BT474, HCC1954, MAD-MB-468, MDA-MB-231, and MCF-10A cells with IC50s of 9.75±0.16, 0.94±0.01, 3.89±0.08, 0.97±0.01, and 57.01±0.76 μM, respectively[2].
Pyoluteorin (0.1-10 μM; for 24 hours) induces change of apoptosis-related protein expressions. Pyoluteorin-induced cell apoptosis in MDA-MB-231 is related to Bcl-2 family proteins and caspase cascade[2].
Pyoluteorin (0.1-10 μM; for 24 h) induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Human triple-negative breast cancer cell MDA-MB-231
Concentration: 0, 0.032, 0.16, 0.8, 4, 20, 100 μM
Incubation Time: 24, 48, 72 hours
Result: Inhibited cells proliferation in a dose- and time-dependent manner.

Western Blot Analysis[2]

Cell Line: MDA-MB-231 cells
Concentration: 0.1, 0.3, 1, 3, 10 μM
Incubation Time: 24 hours
Result: The levels of the anti-apoptotic proteins Bcl-2, Bcl-XL and PARP were obviously decreased while the pro-apoptotic proteins BAX and caspase 3 were increased in a dose-dependent manner.

分子量

272.08

Formula

C11H7Cl2NO3
CAS 号

25683-07-2
中文名称

藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. B Nowak-Thompson, et al. Characterization of the pyoluteorin biosynthetic gene cluster of Pseudomonas fluorescens Pf-5. J Bacteriol. 1999 Apr;181(7):2166-74.

    [2]. Ting Ding, et al. Pyoluteorin induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231. J Pharm Pharmacol. 2020 Jul;72(7):969-978.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Pyoluteorin(Synonyms: 藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素)

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pyoluteorin (Synonyms: 藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素)

Pyoluteorin 是一种抗生素 (antibiotic)，可抑制 Oomycete fungi，包括植物病原体 Oomycete fungi，并抑制由该真菌引起的植物病害。 Pyoluteorin 在体外诱导人三阴性乳腺癌 MDA-MB-231 细胞凋亡 (apoptosis)。 Pyoluteorin 可用于人类三阴性乳腺癌的研究。

Pyoluteorin(Synonyms: 藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素)

Pyoluteorin Chemical Structure

CAS No. : 25683-07-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses plant diseases caused by this fungus[1]. Pyoluteorin induces human triple-negative breast cancer MDA-MB-231 cells apoptosis in vitro. Pyoluteorin can be used for the research of human triple-negative breast cancer[2].

体外研究
(In Vitro)

Pyoluteorin is an antifungal compound composed of a bichlorinated pyrrole linked to a resorcinol moiety, were identified within a 24-kb genomic region of Pseudomonas fluorescens Pf-5[1].
Pyoluteorin has significant cytotoxicity towards MCF-7 (IC50=1.84 μM). Pyoluteorin also displays significantly selective cytotoxicity against BT474, HCC1954, MAD-MB-468, MDA-MB-231, and MCF-10A cells with IC50s of 9.75±0.16, 0.94±0.01, 3.89±0.08, 0.97±0.01, and 57.01±0.76 μM, respectively[2].
Pyoluteorin (0.1-10 μM; for 24 hours) induces change of apoptosis-related protein expressions. Pyoluteorin-induced cell apoptosis in MDA-MB-231 is related to Bcl-2 family proteins and caspase cascade[2].
Pyoluteorin (0.1-10 μM; for 24 h) induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Human triple-negative breast cancer cell MDA-MB-231
Concentration: 0, 0.032, 0.16, 0.8, 4, 20, 100 μM
Incubation Time: 24, 48, 72 hours
Result: Inhibited cells proliferation in a dose- and time-dependent manner.

Western Blot Analysis[2]

Cell Line: MDA-MB-231 cells
Concentration: 0.1, 0.3, 1, 3, 10 μM
Incubation Time: 24 hours
Result: The levels of the anti-apoptotic proteins Bcl-2, Bcl-XL and PARP were obviously decreased while the pro-apoptotic proteins BAX and caspase 3 were increased in a dose-dependent manner.

分子量

272.08

Formula

C11H7Cl2NO3
CAS 号

25683-07-2
中文名称

藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. B Nowak-Thompson, et al. Characterization of the pyoluteorin biosynthetic gene cluster of Pseudomonas fluorescens Pf-5. J Bacteriol. 1999 Apr;181(7):2166-74.

    [2]. Ting Ding, et al. Pyoluteorin induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231. J Pharm Pharmacol. 2020 Jul;72(7):969-978.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Pyoluteorin(Synonyms: 藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素)

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pyoluteorin (Synonyms: 藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素)

Pyoluteorin 是一种抗生素 (antibiotic)，可抑制 Oomycete fungi，包括植物病原体 Oomycete fungi，并抑制由该真菌引起的植物病害。 Pyoluteorin 在体外诱导人三阴性乳腺癌 MDA-MB-231 细胞凋亡 (apoptosis)。 Pyoluteorin 可用于人类三阴性乳腺癌的研究。

Pyoluteorin(Synonyms: 藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素)

Pyoluteorin Chemical Structure

CAS No. : 25683-07-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses plant diseases caused by this fungus[1]. Pyoluteorin induces human triple-negative breast cancer MDA-MB-231 cells apoptosis in vitro. Pyoluteorin can be used for the research of human triple-negative breast cancer[2].

体外研究
(In Vitro)

Pyoluteorin is an antifungal compound composed of a bichlorinated pyrrole linked to a resorcinol moiety, were identified within a 24-kb genomic region of Pseudomonas fluorescens Pf-5[1].
Pyoluteorin has significant cytotoxicity towards MCF-7 (IC50=1.84 μM). Pyoluteorin also displays significantly selective cytotoxicity against BT474, HCC1954, MAD-MB-468, MDA-MB-231, and MCF-10A cells with IC50s of 9.75±0.16, 0.94±0.01, 3.89±0.08, 0.97±0.01, and 57.01±0.76 μM, respectively[2].
Pyoluteorin (0.1-10 μM; for 24 hours) induces change of apoptosis-related protein expressions. Pyoluteorin-induced cell apoptosis in MDA-MB-231 is related to Bcl-2 family proteins and caspase cascade[2].
Pyoluteorin (0.1-10 μM; for 24 h) induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Human triple-negative breast cancer cell MDA-MB-231
Concentration: 0, 0.032, 0.16, 0.8, 4, 20, 100 μM
Incubation Time: 24, 48, 72 hours
Result: Inhibited cells proliferation in a dose- and time-dependent manner.

Western Blot Analysis[2]

Cell Line: MDA-MB-231 cells
Concentration: 0.1, 0.3, 1, 3, 10 μM
Incubation Time: 24 hours
Result: The levels of the anti-apoptotic proteins Bcl-2, Bcl-XL and PARP were obviously decreased while the pro-apoptotic proteins BAX and caspase 3 were increased in a dose-dependent manner.

分子量

272.08

Formula

C11H7Cl2NO3
CAS 号

25683-07-2
中文名称

藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. B Nowak-Thompson, et al. Characterization of the pyoluteorin biosynthetic gene cluster of Pseudomonas fluorescens Pf-5. J Bacteriol. 1999 Apr;181(7):2166-74.

    [2]. Ting Ding, et al. Pyoluteorin induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231. J Pharm Pharmacol. 2020 Jul;72(7):969-978.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Pyoluteorin

发表于由

Pyoluteorin

具有广泛生物特征的小氯化吡咯
97%

有货

Pyoluteorin

CAS编号 25683-07-2 | 品牌：Jinpan
Pyoluteorin

MSDS

质检证书(CoA)

相似产品

  • 分子式 C11H7Cl2NO3
  • 分子量272.08
  • Beilstein号 234664
  • PubChem编号 33137

货号 (SKU) 包装规格 是否现货 价格 数量
P329250-2.5mg 2.5mg 期货 Pyoluteorin  

基本信息

产品名称 Pyoluteorin
英文名称 Pyoluteorin
别名 藤黄绿菌素;藤黄绿脓菌素;黄绿脓菌素
英文别名 (4,5-dichloro-1H-pyrrol-2-yl)-(2,6-dihydroxyphenyl)methanone
规格或纯度 97%
运输条件 超低温冰袋运输

一般描述

Pyoluteorin 是一种抗生素 (antibiotic)，可抑制 Oomycete fungi，包括植物病原体 Oomycete fungi，并抑制由该真菌引起的植物病害。 Pyoluteorin 在体外诱导人三阴性乳腺癌 MDA-MB-231 细胞凋亡 (apoptosis)。 Pyoluteorin 可用于人类三阴性乳腺癌的研究。

Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses plant diseases caused by this fungus. Pyoluteorin induces human triple-negative breast cancer MDA-MB-231 cells apoptosis in vitro. Pyoluteorin can be used for the research of human triple-negative breast cancer.

相关属性

CAS编号 25683-07-2
折光率 n20D1.70 (Predicted)
熔点 177.04° C (Predicted)
沸点 436.86° C at 760 mmHg (Predicted)
溶解性 Soluble in ethanol, methanol, DMF, DMSO, and water (limited).
储存温度 -20°C储存,充氩
RTECS OB1804400
密度 1.63 g/cm3(Predicted)
分子量 272.08
分子式 C11H7Cl2NO3
品牌 Jinpan
Smiles C1=CC(=C(C(=C1)O)C(=O)C2=CC(=C(N2)Cl)Cl)O
PubChem CID 33137