标签归档：riboside

Adenosine(Synonyms: 腺苷; Adenine riboside; D-Adenosine)

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Adenosine (Synonyms: 腺苷; Adenine riboside; D-Adenosine) 纯度: 99.92%

Adenosine (Adenine riboside) 是一种普遍存在的内源性分泌物，是通过四种G蛋白偶联受体（A1、A2A、A2B 和 A3）的起作用。Adenosine 几乎影响细胞生理学的所有方面，包括神经元活动、血管功能、血小板聚集和血细胞调节。

Adenosine(Synonyms: 腺苷; Adenine riboside; D-Adenosine)

Adenosine Chemical Structure

CAS No. : 58-61-7

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥500 In-stock
500 mg ￥350 In-stock
1 g ￥465 In-stock
5 g ￥650 In-stock
10 g   询价  
50 g   询价  

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生物活性

Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[1][2].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Adenosine (Adenine riboside) acts on four G-protein coupled receptors: two of them, A1 and A3, are primarily coupled to Gi family G proteins; and two of them, A2A and A2B, are mostly coupled to Gs like G proteins. These receptors are antagonized by xanthines including caffeine. Via these receptors it affects many cells and organs, usually having a cytoprotective function[2].
Adenosine is an extracellular signaling molecule that is generated from its precursor molecules 5’-adenosine triphosphate (ATP) and 5’-adenosine monophosphate (AMP)[3].
Adenosine is a common metabolite of ATP, which exhibits cytotoxic effects at high concentrations.Adenosine (1.0-4.0 mM; 12-24 hours) inhibits cell viability and triggers ER stress in HepG2 cells[4].
Adenosine induces apoptosis in a variety of cancer cells. Adenosine (2.0 mM; 12-24 hours) induces autophagy in HepG2 cells. In HepG2 cell lines, Adenosine -induced AMPK/mTOR pathway activation partially blocked ER stress and decreased apoptotic cell death[4].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

267.24

Formula

C10H13N5O4
CAS 号

58-61-7
中文名称

腺苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 33.33 mg/mL (124.72 mM; Need ultrasonic)

H2O : ≥ 6.67 mg/mL (24.96 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.7420 mL 18.7098 mL 37.4195 mL
5 mM 0.7484 mL 3.7420 mL 7.4839 mL
10 mM 0.3742 mL 1.8710 mL 3.7420 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 2007;14(7):1315-1323.

    [2]. Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pharmacology of Adenosine Receptors: The State of the Art. Physiol Rev. 2018;98(3):1591-1625.

    [3]. Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology. 2009;111(4):904-915.

    [4]. Zhou XT, et al. Inhibition of autophagy enhances adenosine induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep. 2019;41(2):829-838.

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Creatine riboside

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Creatine riboside  纯度: ≥98.0%

Creatine riboside 是一种尿代谢产物，也是一种肺癌的诊断和预后的生物标志物。

Creatine riboside

Creatine riboside Chemical Structure

CAS No. : 1616693-92-5

规格 价格 是否有货 数量
5 mg ￥3500 In-stock
10 mg ￥6000 In-stock
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生物活性

Creatine riboside is a urinary metabolite and is a diagnostic and prognostic biomarker of lung cancer[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

体内研究
(In Vivo)

The urinary metabolites Creatine riboside and N-acetylneuraminic acid (NANA), are significantly increased in intrahepatic cholangiocarcinoma (ICC)[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

263.25

Formula

C9H17N3O6
CAS 号

1616693-92-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)
参考文献

  • [1]. Mathé EA, et al. Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer. Cancer Res. 2014 Jun 15;74(12):3259-70.

    [2]. Haznadar M, et al. Urinary Metabolites Diagnostic and Prognostic of Intrahepatic Cholangiocarcinoma. Cancer Epidemiol Biomarkers Prev. 2019 Oct;28(10):1704-1711.

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5,6-Dichlorobenzimidazole riboside(Synonyms: DRB)

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5,6-Dichlorobenzimidazole riboside (Synonyms: DRB) 纯度: 99.87%

5,6-Dichlorobenzimidazole riboside 是一种核苷类似物，可抑制几种羧基末端结构域激酶，包括酪蛋白激酶 II 和细胞周期依赖性激酶[2]。5,6-Dichlorobenzimidazole riboside 在不诱导健康细胞遗传毒性应激的情况下，诱导人类结肠腺癌细胞的 p53 依赖性凋亡。

5,6-Dichlorobenzimidazole riboside(Synonyms: DRB)

5,6-Dichlorobenzimidazole riboside Chemical Structure

CAS No. : 53-85-0

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25 mg ￥900 In-stock
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生物活性

5,6-Dichlorobenzimidazole riboside is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II and CDKs[1][2][3][4]. 5,6-Dichlorobenzimidazole riboside trigger p53-dependent apoptosis of human colon adenocarcinoma cells without inducing genotoxic stress to healthy cells[5].

分子量

319.14

Formula

C12H12Cl2N2O4
CAS 号

53-85-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMF : 100 mg/mL (313.34 mM; Need ultrasonic)

Ethanol : 7.69 mg/mL (24.10 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1334 mL 15.6671 mL 31.3342 mL
5 mM 0.6267 mL 3.1334 mL 6.2668 mL
10 mM 0.3133 mL 1.5667 mL 3.1334 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Zandomeni RO. Kinetics of inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole on calf thymus casein kinase II. Biochem J. 1989 Sep 1;262(2):469-73.

    [2]. Yankulov K, et al. The transcriptional elongation inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinase. J Biol Chem. 1995 Oct 13;270(41):23922-5.

    [3]. Rickert P, et al. Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases. Oncogene. 1999 Jan 28;18(4):1093-102.

    [4]. Schang LM. Cyclin-dependent kinases as cellular targets for antiviral drugs. J Antimicrob Chemother. 2002 Dec;50(6):779-92.

    [5]. te Poele RH, et al. RNA synthesis block by 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells. Oncogene. 1999 Oct 14;18(42):5765-72.

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Nicotinic acid riboside(Synonyms: 烟酸核糖)

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Nicotinic acid riboside (Synonyms: 烟酸核糖) 纯度: 99.50%

Nicotinic acid riboside 存在于人体细胞中，是一种 NAD+ 前体。Nicotinic acid riboside 是人类 NAD+ 代谢的中间体。

Nicotinic acid riboside(Synonyms: 烟酸核糖)

Nicotinic acid riboside Chemical Structure

CAS No. : 17720-18-2

规格 价格 是否有货 数量
10 mg ￥2800 In-stock
50 mg ￥7500 In-stock
100 mg ￥12000 In-stock
200 mg   询价  
500 mg   询价  

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生物活性

Nicotinic acid riboside is a NAD+ precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD+ metabolism[1][2].

体外研究
(In Vitro)

Nicotinic acid riboside (HepG2 cells; 0.01 nM~0.1 mM) helps FK866-treated cells to maintain viability at low micromolar concentrations[1].
. Nicotinic acid riboside formation and release are caused by overexpression of FLAG-tagged CN-II and CN-III in HEK293 and HepG2 cells. CN-II and CN-III generate Nicotinic acid riboside in vitro by dephosphorylation of nicotinic acid mononucleotide (NAMN)[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

255.22

Formula

C11H13NO6
CAS 号

17720-18-2
中文名称

烟酸核糖
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : 62.5 mg/mL (244.89 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.9182 mL 19.5909 mL 39.1819 mL
5 mM 0.7836 mL 3.9182 mL 7.8364 mL
10 mM 0.3918 mL 1.9591 mL 3.9182 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Sasaki Y, et al. Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection. Exp Neurol. 2021;345:113842.

    [2]. Bogan KL, et al. Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5′-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside [published correction appears in J Biol Chem. 2010 Jan 29;285(5):3524]. J Biol Chem. 2009;284(50):34861-34869.

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Kinetin riboside(Synonyms: N6-Furfuryladenosine)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Kinetin riboside (Synonyms: N6-Furfuryladenosine) 纯度: 99.89%

Kinetin riboside是细胞分裂素类似物，可诱导癌症细胞死亡。抑制HCT-15细胞增殖的IC50值为2.5 μM。

Kinetin riboside(Synonyms: N6-Furfuryladenosine)

Kinetin riboside Chemical Structure

CAS No. : 4338-47-0

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥770 In-stock
100 mg ￥700 In-stock
200 mg   询价  
500 mg   询价  

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生物活性

Kinetin riboside, a cytokinin analog, can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells with an IC50 of 2.5 μM.

IC50 & Target

IC50: 2.5 μM (HCT-15 cells)[1]
体外研究
(In Vitro)

Kinetin riboside displays antiproliferative and apoptogenic activity against various human cancer cell lines. Kinetin riboside is able to inhibit the proliferation in HCT-15 human colon cancer cells in a dose-dependent manner (IC50=2.5 μM)[1]. Kinetin riboside induces apoptosis in HeLa and mouse melanoma B16F-10 cells. Kinetin riboside disrupts the mitochondrial membrane potential and induces the release of cytochrome c and activation of caspase-3. Bad are up-regulated while Bcl-2 is down-regulated under kinetin riboside exposure[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Kinetin riboside significantly suppresses tumor growth. The most effective anti-melanoma response is elicited at 40 mg/kg[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

347.33

Formula

C15H17N5O5
CAS 号

4338-47-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 250 mg/mL (719.78 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8791 mL 14.3955 mL 28.7911 mL
5 mM 0.5758 mL 2.8791 mL 5.7582 mL
10 mM 0.2879 mL 1.4396 mL 2.8791 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.99 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (5.99 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.99 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (5.99 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.99 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (5.99 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Rajabi M, et al. Antiproliferative activity of kinetin riboside on HCT-15 colon cancer cell line. Nucleosides Nucleotides Nucleic Acids. 2012;31(6):474-81.

    [2]. Choi BH, et al. Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells. Cancer Lett. 2008 Mar 8;261(1):37-45.
Cell Assay
[2]

HeLa and mouse melanoma B16F-10 cells are treated with 5, 10, 20 μM kinetin riboside for 48 h. 15 μL of MTT solution (5 mg/mL) is added to each well and cells are maintained for 4 h at 37°C. Hundred microlitres of solubilizing solution is then added. After an overnight incubation at room temperature, absorbance at 490 nm is measured[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[2]

Mice: Male C57BL/6 mice are injected B16 F-10 cells. After 5 days for tumor growth, kinetin riboside (10, 20, 40 mg/kg) is injected to tumor mass directly. Drug injection is performed once a 3 days for three times. After third injection of drug, mice are kept for 3 days with no injection and tumor mass is removed from each mouse and weighed[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Rajabi M, et al. Antiproliferative activity of kinetin riboside on HCT-15 colon cancer cell line. Nucleosides Nucleotides Nucleic Acids. 2012;31(6):474-81.

    [2]. Choi BH, et al. Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells. Cancer Lett. 2008 Mar 8;261(1):37-45.

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