标签归档：sgd

SGD-1910

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SGD-1910  纯度: 95.06%

SGD-1910 是抗体偶联药物的一部分 (drug-linker conjugate for ADC)，它由 PBD (一种细胞毒性 DNA 交联剂) 和可降解 (cleavable) 的 MC-Val-Ala 连接而成。

SGD-1910

SGD-1910 Chemical Structure

CAS No. : 1342820-51-2

规格 价格 是否有货 数量
1 mg ￥9500 In-stock
5 mg ￥28000 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

生物活性

SGD-1910 is a drug-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala[1].

IC50 & Target[1]

Pyrrolobenzodiazepines

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1089.20

Formula

C60H64N8O12
CAS 号

1342820-51-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献

  • [1]. John A Hartley. Antibody-drug conjugates (ADCs) delivering pyrrolobenzodiazepine (PBD) dimers for cancer therapy. Expert Opin Biol Ther. 2020 Jun 16;1-13.

    [2]. Jeffrey SC, et al. A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology. Bioconjug Chem. 2013 Jul 17;24(7):1256-63.

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彼爱姆BM-SG10D高级生物显微镜

发表于由

彼爱姆BM-SG10D高级生物显微镜

  • 品牌 彼爱姆|BM
  • 型号 BM-SG10D
  • 商品详情

    产品介绍

    BM-SG10D 高级生物显微镜采用无限远光学技术

    采用半复消色差无限远平场物镜，扩展性强可配备垂直照明装置、荧光装置等辅助设备

    广泛用于组织学、生物学、细菌学、病理学、药物化学等研究领域及大专院校的教学工作和医学界的临床分析与实验等。

    本仪器采用光源，照明可连续调节亮度，三目铰链式观察筒，30°倾斜，可360度自由转动。

    技术规格

    1、目镜

    类别 放大倍数 视场直径
    高眼点宽视野平场目镜 10X Φ23mm
    16X（选购） Φ17mm

    2、物镜

    类别 放大倍数 数值孔径 工作距离
    半复消色差
    无限远平场物镜    		 4X 0.10 29.4mm
    10X 0.25 16.0mm
    20X 0.40 3.0mm
    40X(S) 0.65 0.63mm
    100X（S）Oil 1.25 0.35mm

    3、机械筒长： 无限远系统(∞)

    4、放大倍数：40X-1000X

    （显微镜的总放大倍率：显微镜的总放大倍率=物镜倍率×镜筒系数倍率×目镜倍率）

    5、物镜转换器：六孔转换器

    6、镜筒透镜：焦距：f=200mm

    7、载物台尺寸：双层移动平台189×160mm，移动范围 80×50mm　

    8、瞳距：55-75 mm

    9、调焦装置：30mm粗微动同轴调焦带限位,粗动调焦张力锁紧装置 微调格值0.002mm

    10、聚光镜：N.A.1.25阿贝聚光镜可调中带可变光栏

    11、滤色片：蓝、绿、中性

    12、光源：12V/50W卤素灯,柯勒照明,光源可调

    • SGD-1882(Synonyms: PBD dimer)

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    SGD-1882 (Synonyms: PBD dimer) 纯度: 98.45%

    SGD-1882 是一种有细胞毒性的 DNA 小沟交联剂，为 PBD 二聚体，可以作为 ADC 的有效载荷。

    SGD-1882(Synonyms: PBD dimer)

    SGD-1882 Chemical Structure

    CAS No. : 1222490-34-7

    规格 价格 是否有货 数量
    1 mg ￥10500 In-stock
    5 mg   询价  
    10 mg   询价  

    * Please select Quantity before adding items.

    SGD-1882 相关产品

    •相关化合物库:

    • Bioactive Compound Library Plus
    • Toxins for Antibody-Drug Conjugate Research Library

    生物活性

    SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.

    体外研究
    (In Vitro)

    SGD-1882 is the cytotoxic payload undergoing clinical evaluation for anti-CD33 and anti-CD70 conjugates[1]. SGD-1882 is not an MDR1 substrate, and SGN-CD33A is conjugated to the SGD-1882. SGN-CD33A can kill MDR1 expressing CD33 positive AML patient samples and is currently in Phase I[2].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    725.79

    Formula

    C42H39N5O7
    CAS 号

    1222490-34-7
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    参考文献

    • [1]. Eunhee G. Kim, et al. Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted Cancer Therapeutics. Biomol Ther (Seoul). 2015 Nov; 23(6): 493-509.

      [2]. Dowdy Jackson, et al. Using the Lessons Learned From the Clinic to Improve the Preclinical Development of Antibody Drug Conjugates. Pharm Res. 2015; 32(11): 3458-3469.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    Dimethyl-SGD-1882(Synonyms: Dimethyl-PBD dimer)

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Dimethyl-SGD-1882 (Synonyms: Dimethyl-PBD dimer)

    Dimethyl-SGD-1882 (Dimethyl-PBD dimer) 是一种高效的 DNA 烷化剂 (DNA alkylator)，可作用做抗体偶联药物 (ADC) 的毒素部分。PBD Dimer 是一种 DNA 烷化剂，能抑制 DNA 复制。

    Dimethyl-SGD-1882(Synonyms: Dimethyl-PBD dimer)

    Dimethyl-SGD-1882 Chemical Structure

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication[1].

    IC50 & Target[1]

    Pyrrolobenzodiazepines

     

    体外研究
    (In Vitro)

    The unique structure of the pyrrolobenzodiazepine (PBD) dimers which contain two alkylating imine functionalities allows them to form interstrand or intrastrand DNA cross‐links in addition to mono‐alkylated adducts, thus resulting in greater DNA stabilization compared to monomeric PBDs. Due to the additional types of DNA adducts possible and the greater adduct stability, the C8‐linked PBD dimers generally have significantly greater cytotoxicity, antitumor activity and antibacterial activity compared to PBD monomers, and one such agent, SJG‐136, has reached Phase II clinical trials in ovarian cancer and leukaemia. Furthermore, related PBD dimers are now being used as payloads for antibody-drug conjugates (ADCs) due to their significant cytotoxicity[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    753.84

    Formula

    C44H43N5O7
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Mantaj J, et al. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs). Angew Chem Int Ed Engl. 2017 Jan 9;56(2):462-488.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    Dimethyl-SGD-1882(Synonyms: Dimethyl-PBD dimer)

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Dimethyl-SGD-1882 (Synonyms: Dimethyl-PBD dimer)

    Dimethyl-SGD-1882 (Dimethyl-PBD dimer) 是一种高效的 DNA 烷化剂 (DNA alkylator)，可作用做抗体偶联药物 (ADC) 的毒素部分。PBD Dimer 是一种 DNA 烷化剂，能抑制 DNA 复制。

    Dimethyl-SGD-1882(Synonyms: Dimethyl-PBD dimer)

    Dimethyl-SGD-1882 Chemical Structure

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication[1].

    IC50 & Target[1]

    Pyrrolobenzodiazepines

     

    体外研究
    (In Vitro)

    The unique structure of the pyrrolobenzodiazepine (PBD) dimers which contain two alkylating imine functionalities allows them to form interstrand or intrastrand DNA cross‐links in addition to mono‐alkylated adducts, thus resulting in greater DNA stabilization compared to monomeric PBDs. Due to the additional types of DNA adducts possible and the greater adduct stability, the C8‐linked PBD dimers generally have significantly greater cytotoxicity, antitumor activity and antibacterial activity compared to PBD monomers, and one such agent, SJG‐136, has reached Phase II clinical trials in ovarian cancer and leukaemia. Furthermore, related PBD dimers are now being used as payloads for antibody-drug conjugates (ADCs) due to their significant cytotoxicity[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    753.84

    Formula

    C44H43N5O7
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Mantaj J, et al. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs). Angew Chem Int Ed Engl. 2017 Jan 9;56(2):462-488.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    Dimethyl-SGD-1882(Synonyms: Dimethyl-PBD dimer)

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Dimethyl-SGD-1882 (Synonyms: Dimethyl-PBD dimer)

    Dimethyl-SGD-1882 (Dimethyl-PBD dimer) 是一种高效的 DNA 烷化剂 (DNA alkylator)，可作用做抗体偶联药物 (ADC) 的毒素部分。PBD Dimer 是一种 DNA 烷化剂，能抑制 DNA 复制。

    Dimethyl-SGD-1882(Synonyms: Dimethyl-PBD dimer)

    Dimethyl-SGD-1882 Chemical Structure

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication[1].

    IC50 & Target[1]

    Pyrrolobenzodiazepines

     

    体外研究
    (In Vitro)

    The unique structure of the pyrrolobenzodiazepine (PBD) dimers which contain two alkylating imine functionalities allows them to form interstrand or intrastrand DNA cross‐links in addition to mono‐alkylated adducts, thus resulting in greater DNA stabilization compared to monomeric PBDs. Due to the additional types of DNA adducts possible and the greater adduct stability, the C8‐linked PBD dimers generally have significantly greater cytotoxicity, antitumor activity and antibacterial activity compared to PBD monomers, and one such agent, SJG‐136, has reached Phase II clinical trials in ovarian cancer and leukaemia. Furthermore, related PBD dimers are now being used as payloads for antibody-drug conjugates (ADCs) due to their significant cytotoxicity[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    753.84

    Formula

    C44H43N5O7
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Mantaj J, et al. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs). Angew Chem Int Ed Engl. 2017 Jan 9;56(2):462-488.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务