Shp | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SHP2-IN-6

SHP2-IN-6 是一种有效的 SHP2 抑制剂，IC₅₀ 值为 25.8 nM，详细信息请参见专利WO2017211303A1，compound 7。

SHP2-IN-6 Chemical Structure

CAS No. : 2169223-48-5

* Please select Quantity before adding items.

SHP2-IN-6 的其他形式现货产品:

SHP2-IN-6 hydrochloride

生物活性	SHP2-IN-6 is a potent SHP2 inhibitor, extracted from patent WO2017211303A1, compound 7, has an IC₅₀ of 25.8 nM^[1].
体外研究 (In Vitro)	SHP2-IN-6 inhibits the proliferation of KYSE-520 cells with an IC₅₀ of 2.17 μM^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	476.54
Formula	C₂₂H₂₆F₂N₆O₂S
CAS 号	2169223-48-5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Cunbo Ma, et al. Novel heterocyclic derivatives useful as shp2 inhibitors. WO2017211303A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SHP2 protein degrader-2

SHP2 protein degrader-2 (SHP2-D26) 是一种 SHP2 蛋白 PROTAC 降解剂。SHP2 protein degrader-2 可降低各种癌细胞中 SHP2 的表达水平。

SHP2 protein degrader-2 Chemical Structure

CAS No. : 2740582-16-3

* Please select Quantity before adding items.

生物活性	SHP2 protein degrader-2 (SHP2-D26) is a SHP2 protein PROTAC degrader. SHP2 protein degrader-2 reduces expression level of SHP2 in various cancer cells^[1].
体外研究 (In Vitro)	SHP2 protein degrader-2 (SHP2-D26) achieves excellent degradation of SHP2 with the DC₅₀ (the concentration where 50% of the protein has been degraded) values of 2.6 nM and 6.0 nM for MV4;11 and KYSE520 cells, respectively^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	1115.89
Formula	C₅₆H₇₉ClN₁₂O₆S₂
CAS 号	2740582-16-3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Song Y, et al. Strategies Targeting Protein Tyrosine Phosphatase SHP2 for Cancer Therapy. J Med Chem. 2022 Feb 24;65(4):3066-3079.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

whatman (沃特曼)