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Sirpiglenastat (Synonyms: DRP-104)
Sirpiglenastat (DRP-104) 是一种广泛作用的谷氨酰胺 (glutamine) 拮抗剂。Sirpiglenastat通过直接靶向肿瘤代谢并同时诱导有效的抗肿瘤免疫反应而具有抗癌作用。
Sirpiglenastat Chemical Structure
CAS No. : 2079939-05-0
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生物活性 |
Sirpiglenastat (DRP-104) is a broad acting glutamine antagonist. Sirpiglenastat has anticancer effects by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response[1][2]. |
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体外研究 (In Vitro) |
Sirpiglenastat (DRP-104) treatment shows broad immune cell modulation effects including increased T, NK, and macrophages. Sirpiglenastat decreases pro-tumorigenic cytokines such as VEGF and KC (IL-8)[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
CT26 bearing mice treated with Sirpiglenastat (DRP-104) (0.5 mg/kg; s.c.; once a day; for 5 days) shows tumor growth inhibition at day 12 of 90%. Median survival days are 36 days[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
441.48 |
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Formula |
C22H27N5O5 |
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CAS 号 |
2079939-05-0 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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