LC-SMCC (succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxy-(6-amidocaproate)) Cat. No. SMCC-LC-1 MW 444.78 100 mg修饰性聚乙二醇

发表于2024年12月20日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

LC-SMCC (succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxy-(6-amidocaproate))

Cat. No.	SMCC-LC-1
Specification	MW 444.78
Unit Size	100 mg
Price	$485.00

Name: LC-SMCC, Long chain-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate

Synonym: LC-SMCC, long chain 4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester

Description:

LC-SMCC, also called Long chain succinimidyl cyclohexane Maleimide, is one of Nanocs' amine and sulfhydryl reactive crosslinkers. This crossliner is non-cleavable and membrane permeable. It contains an amine reactive NHS ester and a sulfhydryl reactive maleimide group. Compared to other maleimide NHS ester, LC-SMCC has higher stability in aqueous solution because of its cyclohexane bridge. NHS esters react with primary amines at pH 7-9 while the maleimide group reacts with available thiol or sulfhydryl at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties of SMCC:

Appearance: Off-white/white solid;
Molecular formula: C22H29N3O7;
Molecular weight: 447.48;
Reactive to: Sulfhydryl and primary amine group;
Purity: >95%
Soluble in DMF or DMSO;

Storage Conditions of LC-SMCC:

LC-SMCC should be stored at -20 ⁰C or lower. Desiccate. Avoid frequent thaw and freeze.

Rha-PEG3-SMCC

发表于2024年12月3日由上海金畔生物科技有限公司

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Rha-PEG3-SMCC

Rha-PEG3-SMCC (compound 13) 是抗体-药物偶联物的一部分，由蛋白质交联剂 SMCC 和不可降解的 ADC linker Rha-PEG3 连接而成。

Rha-PEG3-SMCC Chemical Structure

规格		是否有货
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250 mg		询价
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生物活性

Rha-PEG3-SMCC (compound 13) is a drug-linker conjugate for ADC with potent antitumor activity by using SMCC (a protein crosslinker), linked via the noncleavable ADC linker Rha-PEG3^[1].

IC₅₀ & Target^[1]

Traditional Cytotoxic Agents

分子量

514.57

Formula

C₂₄H₃₈N₂O₁₀

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Kun Zhou, et al. Chemical Synthesis of Antibody-Hapten Conjugates Capable of Recruiting the Endogenous Antibody to Magnify the Fc Effector Immunity of Antibody for Cancer Immunotherapy. J Med Chem. 2022 Jan 13;65(1):323-332.

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Rha-PEG3-SMCC

发表于2024年12月2日由上海金畔生物科技有限公司

Rha-PEG3-SMCC

Rha-PEG3-SMCC (compound 13) 是抗体-药物偶联物的一部分，由蛋白质交联剂 SMCC 和不可降解的 ADC linker Rha-PEG3 连接而成。

Rha-PEG3-SMCC Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

Rha-PEG3-SMCC (compound 13) is a drug-linker conjugate for ADC with potent antitumor activity by using SMCC (a protein crosslinker), linked via the noncleavable ADC linker Rha-PEG3^[1].

IC₅₀ & Target^[1]

Traditional Cytotoxic Agents

分子量

514.57

Formula

C₂₄H₃₈N₂O₁₀

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Kun Zhou, et al. Chemical Synthesis of Antibody-Hapten Conjugates Capable of Recruiting the Endogenous Antibody to Magnify the Fc Effector Immunity of Antibody for Cancer Immunotherapy. J Med Chem. 2022 Jan 13;65(1):323-332.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Rha-PEG3-SMCC

发表于2024年12月2日由上海金畔生物科技有限公司

Rha-PEG3-SMCC

Rha-PEG3-SMCC (compound 13) 是抗体-药物偶联物的一部分，由蛋白质交联剂 SMCC 和不可降解的 ADC linker Rha-PEG3 连接而成。

Rha-PEG3-SMCC Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

Rha-PEG3-SMCC (compound 13) is a drug-linker conjugate for ADC with potent antitumor activity by using SMCC (a protein crosslinker), linked via the noncleavable ADC linker Rha-PEG3^[1].

IC₅₀ & Target^[1]

Traditional Cytotoxic Agents

分子量

514.57

Formula

C₂₄H₃₈N₂O₁₀

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Kun Zhou, et al. Chemical Synthesis of Antibody-Hapten Conjugates Capable of Recruiting the Endogenous Antibody to Magnify the Fc Effector Immunity of Antibody for Cancer Immunotherapy. J Med Chem. 2022 Jan 13;65(1):323-332.

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SMCC-DM1(Synonyms: DM1-SMCC)

发表于2024年9月23日由上海金畔生物科技有限公司

SMCC-DM1 (Synonyms: DM1-SMCC) 纯度: 98.18%

SMCC-DM1 (DM1-SMCC) 是由 linker SMCC 和毒性分子 DM1 连接而成的，可用来制备抗体偶联药物。DM1 (Mertansine)，是含硫醇的美登木素生物碱，是一种有效的微管破坏剂。

SMCC-DM1 Chemical Structure

CAS No. : 1228105-51-8

规格	价格	是否有货
5 mg	￥3300	In-stock
10 mg	￥5100	In-stock
25 mg	￥9900	In-stock
50 mg	￥15500	In-stock
100 mg	￥22000	In-stock
200 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

SMCC-DM1 (DM1-SMCC) is a drug-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker SMCC to make antibody drug conjugate (ADC)^[1].

IC₅₀ & Target

Maytansinoids

体外研究
(In Vitro)

SMCC-DM1 inhibits HCC1954 and MDA-MB-468 cells proliferation with IC₅₀s of 17.2 and 49.9 nM, respectively^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1072.61

Formula

C₅₁H₆₆ClN₅O₁₆S

CAS 号

1228105-51-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (93.23 mM)

* “≥” means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.9323 mL	4.6615 mL	9.3231 mL
5 mM	0.1865 mL	0.9323 mL	1.8646 mL
10 mM	0.0932 mL	0.4662 mL	0.9323 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: 2 mg/mL (1.86 mM); Clear solution; Need ultrasonic

此方案可获得 2 mg/mL (1.86 mM) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: 2 mg/mL (1.86 mM); Clear solution; Need ultrasonic

此方案可获得 2 mg/mL (1.86 mM) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2 mg/mL (1.86 mM); Clear solution

此方案可获得 ≥ 2 mg/mL (1.86 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 20.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Shao S, et al. Site-specific and hydrophilic ADCs through disulfide-bridged linker and branched PEG. Bioorg Med Chem Lett. 2018 May 1;28(8):1363-1370.

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Sulfo-SMCC sodium

发表于2024年9月3日由上海金畔生物科技有限公司

Sulfo-SMCC sodium 纯度: 97.24%

Sulfo-SMCC sodium 是一种常用的异双官能交联剂，是不可降解的 ADC linker，其带有N-羟基琥珀酰亚胺 (NHS) 酯和马来酰亚胺基团，分别与伯胺和巯基反应。

Sulfo-SMCC sodium Chemical Structure

CAS No. : 92921-24-9

规格	价格	是否有货
10 mg	￥500	In-stock
50 mg	￥1300	In-stock
100 mg	￥2300	In-stock
200 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.

IC₅₀ & Target

Non-cleavable

体外研究
(In Vitro)

The crosslinker Sulfo-SMCC consists of a maleimide and an N-hydroxysuccinimide ester group to bind to sulfhydryl groups and primary amines, respectively. Sulfo-SMCC inhibits the end-to-end annealing of stabilized Microtubules (MTs). MTs are treated with 250 μM Sulfo-SMCC, and imaged after incubation for 0 h, 6 h, and 24 h. MTs treated with Sulfo-SMCC shows a constant mean length, independent of the incubation time^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

436.37

Formula

C₁₆H₁₇N₂NaO₉S

CAS 号

92921-24-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:

DMSO : 125 mg/mL (286.45 mM; Need ultrasonic)

H₂O : 5 mg/mL (11.46 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2916 mL	11.4582 mL	22.9163 mL
5 mM	0.4583 mL	2.2916 mL	4.5833 mL
10 mM	0.2292 mL	1.1458 mL	2.2916 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.08 mg/mL (4.77 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.77 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (4.77 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.77 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.08 mg/mL (4.77 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.77 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Prabhune M, et al. Sulfo-SMCC Prevents Annealing of Taxol-Stabilized Microtubules In Vitro. PLoS One. 2016 Aug 25;11(8):e0161623.

Kinase Assay ^[1]	Labeled and unlabeled porcine tubulin powders are used. Sulfo-SMCC is used. MTs are polymerized to a final concentration of 2 mg/mL in 80 mM PIPES buffer (pH 6.8) containing 10 μM taxol, 2 mM MgCl₂, 0.5 mM EGTA, and 1 mM GTP. A mixture of rhodamine-labeled tubulin and unlabeled tubulin (1:5) is used in the time-dependent measurements. In these experiments, polymerized MTs are divided in 2 groups: control and Sulfo-SMCC (250 μM) treated. Both samples are imaged after diluting 1:5 and incubating for 0 h (within 45 minutes after polymerization), 6 h, and 24 h^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Prabhune M, et al. Sulfo-SMCC Prevents Annealing of Taxol-Stabilized Microtubules In Vitro. PLoS One. 2016 Aug 25;11(8):e0161623.

Kinase Assay
^[1]

Labeled and unlabeled porcine tubulin powders are used. Sulfo-SMCC is used. MTs are polymerized to a final concentration of 2 mg/mL in 80 mM PIPES buffer (pH 6.8) containing 10 μM taxol, 2 mM MgCl₂, 0.5 mM EGTA, and 1 mM GTP. A mixture of rhodamine-labeled tubulin and unlabeled tubulin (1:5) is used in the time-dependent measurements. In these experiments, polymerized MTs are divided in 2 groups: control and Sulfo-SMCC (250 μM) treated. Both samples are imaged after diluting 1:5 and incubating for 0 h (within 45 minutes after polymerization), 6 h, and 24 h^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Prabhune M, et al. Sulfo-SMCC Prevents Annealing of Taxol-Stabilized Microtubules In Vitro. PLoS One. 2016 Aug 25;11(8):e0161623.

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DM4-SMCC

发表于2024年8月11日由上海金畔生物科技有限公司

DM4-SMCC

DM4-SMCC 是一种抗体偶联药物 (drug-linker conjugate for ADC)，具有抗肿瘤活性，由抗微管抑制剂 DM4 和不可降解 (non-cleavable) 的 SMCC 连接而成。

DM4-SMCC Chemical Structure

CAS No. : 1228105-52-9

规格	价格	是否有货
10 mg	￥22990	询问价格 & 货期
25 mg	￥45980	询问价格 & 货期
50 mg	￥80460	询问价格 & 货期

* Please select Quantity before adding items.

生物活性

DM4-SMCC is a drug-linker conjugate for ADC with antitumor activity by using DM4 (an antitubulin agent), linked via the non-cleavable SMCC linker^[1].

IC₅₀ & Target

Maytansinoids

分子量

1114.69

Formula

C₅₄H₇₂ClN₅O₁₆S

CAS 号

1228105-52-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Singh R, et al. A New Triglycyl Peptide Linker for Antibody-Drug Conjugates (ADCs) with Improved TargetedKilling of Cancer Cells. Mol Cancer Ther. 2016 Jun;15(6):1311-20.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Lys-SMCC-DM1(Synonyms: Lys-Nε-MCC-DM1)

发表于2024年5月23日由上海金畔生物科技有限公司

Lys-SMCC-DM1 (Synonyms: Lys-Nε-MCC-DM1)

Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) 是一种有效地连接子-载荷 (payload) 组分，具有抑制微管蛋白聚合的潜力。Lys-SMCC-DM1 是 T-DM1 的活性代谢产物。T-DM1 是一种靶向人表皮生长因子受体2 (HER2) 的 ADC ，含有微管蛋白聚合抑制剂 DM1。

Lys-SMCC-DM1 Chemical Structure

CAS No. : 1281816-04-3

规格	价格	是否有货
1 mg	￥3500	询问价格 & 货期
5 mg	￥9500	询问价格 & 货期
10 mg	￥14500	询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is a linker-payload component that has the potential to inhibit tubulin polymerization.Lys-SMCC-DM1 is the active metabolite of T-DM1. T-DM1 is a human epidermal growth factor receptor 2 (HER2)-targeting ADC with a tubulin polymerization inhibitor DM1^[1].

IC₅₀ & Target

Maytansinoids

分子量

1103.71

Formula

C₅₃H₇₅ClN₆O₁₅S

CAS 号

1281816-04-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Ogitani Y, et al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016 Jul;107(7):1039-46.

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SMCC/Maleimidocyclohexane NHS Cat. No. SMC01 MW 334.33 25 mg修饰性聚乙二醇

发表于2024年4月24日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

SMCC/Maleimidocyclohexane NHS

Cat. No.	SMC01
Specification	MW 334.33
Unit Size	25 mg
Price	$385.00

Name: Succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate, SMCC

Synonym: 4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester

Description about SMCC:

SMCC, also called Succinimidyl cyclohexane Maleimide, is one of Nanocs' amine and sulfhydryl reactive crosslinkers. This crossliner is non-cleavable and membrane permeable. It contains an amine reactive NHS ester and a sulfhydryl reactive maleimide group. Compared to other maleimide NHS ester, SMCC has higher stability in aqueous solution because of its cyclohexane bridge. NHS esters react with primary amines at pH 7-9 while the maleimide group reacts with available thiol or sulfhydryl at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties of SMCC:

Appearance: Off-white/white solid;
Molecular formula: C16H18N2O6;
Molecular weight: 334.32;
Spacer arm length: 8.3 angstrom, 9 atoms
CAS number: 64987-85-5;
Purity: >95%
Soluble in DMF or DMSO;

Storage Conditions of SMCC:

SMCC should be stored at -20 ⁰C or lower. Desiccate. Avoid frequent thaw and freeze.

生物活性分子抑制剂SMCC

发表于2024年4月9日由上海金畔生物科技有限公司

SMCC 纯度: 99.25%

SMCC 是一种蛋白质交联剂。SMCC 接合抗原耦合脾脏细胞来诱导抗原特异性免疫反应。

SMCC Chemical Structure

CAS No. : 64987-85-5

规格	价格	是否有货
100 mg	￥500	In-stock
200 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

SMCC is a protein crosslinker. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses^[1].

体外研究
(In Vitro)

SMCC or sulfo-SMCC can use to conjugate keyhole limpet hemocyanin (KLH) and ovalbumin (OVA). In the the conjugation system, 300 μl KLH or OVA (3 mg) and 30 μl SMCC or Sulfo-SMCC (the final concentration of 0.1 mM) are added in PBS with final volume of 3 ml^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Using the SMCC-conjugation method is able to induce potent immune responses to whole protein or peptide antigens by injection of antigen-coupled syngeneic splenic mononuclear cells in mice^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

334.32

Formula

C₁₆H₁₈N₂O₆

CAS 号

64987-85-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:

DMSO : 25 mg/mL (74.78 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (ultrasonic) (insoluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.9911 mL	14.9557 mL	29.9115 mL
5 mM	0.5982 mL	2.9911 mL	5.9823 mL
10 mM	0.2991 mL	1.4956 mL	2.9911 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (7.48 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.48 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (7.48 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.48 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.48 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.48 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Guo Y, et al. Potent antigen-specific immune response induced by infusion of spleen cells coupled with succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate (SMCC) conjugated antigens. Int Immunopharmacol. 2016 Feb;31:158-68.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

生物活性分子抑制剂SMCC

发表于2024年4月9日由上海金畔生物科技有限公司

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。
SMCC 纯度: 99.25%

SMCC 是一种蛋白质交联剂。SMCC 接合抗原耦合脾脏细胞来诱导抗原特异性免疫反应。

SMCC Chemical Structure

CAS No. : 64987-85-5

规格	价格	是否有货
100 mg	￥500	In-stock
200 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

SMCC is a protein crosslinker. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses^[1].

体外研究
(In Vitro)

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Using the SMCC-conjugation method is able to induce potent immune responses to whole protein or peptide antigens by injection of antigen-coupled syngeneic splenic mononuclear cells in mice^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

334.32

Formula

C₁₆H₁₈N₂O₆

CAS 号

64987-85-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:

DMSO : 25 mg/mL (74.78 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (ultrasonic) (insoluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.9911 mL	14.9557 mL	29.9115 mL
5 mM	0.5982 mL	2.9911 mL	5.9823 mL
10 mM	0.2991 mL	1.4956 mL	2.9911 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (7.48 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.48 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (7.48 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.48 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.48 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.48 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Guo Y, et al. Potent antigen-specific immune response induced by infusion of spleen cells coupled with succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate (SMCC) conjugated antigens. Int Immunopharmacol. 2016 Feb;31:158-68.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

trans-Sulfo-SMCC

发表于2024年3月12日由上海金畔生物科技有限公司

trans-Sulfo-SMCC

trans-Sulfo-SMCC 是一种不可裂解的可透过膜的 ADC 交联剂。

trans-Sulfo-SMCC Chemical Structure

CAS No. : 1286837-77-1

规格	价格	是否有货
500 mg	￥27590	询问价格 & 货期

* Please select Quantity before adding items.

生物活性

trans-Sulfo-SMCC is a non-cleavable and membrane permeable ADC crosslinker.

IC₅₀ & Target

Non-cleavable

分子量

414.39

Formula

C₁₆H₁₈N₂O₉S

CAS 号

1286837-77-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

MMAE-SMCC

发表于2024年2月20日由上海金畔生物科技有限公司

MMAE-SMCC

MMAE-SMCC 是由有效的有丝分裂和微管蛋白抑制剂 MMAE 和接头 SMCC 组成的抗体偶联药物，可制成抗体药物偶联物。

MMAE-SMCC Chemical Structure

CAS No. : 2021179-11-1

规格	价格	是否有货
1 mg	￥7000	询问价格 & 货期
5 mg	￥17500	询问价格 & 货期
10 mg	￥28000	询问价格 & 货期

* Please select Quantity before adding items.

生物活性

MMAE-SMCC is a drug-linker conjugate for ADC. MMAE-SMCC is composed of a potent mitotic and a tubulin inhibitor MMAE and a linker SMCC to make antibody drug conjugate^[1].

IC₅₀ & Target^[1]

Auristatin

分子量

1140.43

Formula

C₅₈H₈₉N₇O₁₄S

CAS 号

2021179-11-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据

In Vitro:

DMSO : 220 mg/mL (192.91 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.8769 mL	4.3843 mL	8.7686 mL
5 mM	0.1754 mL	0.8769 mL	1.7537 mL
10 mM	0.0877 mL	0.4384 mL	0.8769 mL

请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 5.5 mg/mL (4.82 mM); Clear solution

此方案可获得 ≥ 5.5 mg/mL (4.82 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 55.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
2.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 5.5 mg/mL (4.82 mM); Clear solution

此方案可获得 ≥ 5.5 mg/mL (4.82 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 55.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Tang F, et al. One-pot N-glycosylation remodeling of IgG with non-natural sialylglycopeptides enables glycosite-specific and dual-payload antibody-drug conjugates. Org Biomol Chem. 2016 Oct 12;14(40):9501-9518.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SMCC-PEG4-NHS Cat. No. M2-P4S-1 5 mg修饰性聚乙二醇

发表于2024年1月23日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

SMCC-PEG4-NHS

Cat. No.	M2-P4S-1
Specification
Unit Size	5 mg
Price	$385.00

Description:

Nanocs SnapLink^TM pegylated succinimidyl cyclohexane Maleimide (SMCC) is an amine and sulfhydryl reactive crosslinker. This crosslinker is non-cleavable and membrane permeable. It contains an amine reactive NHS ester and a sulfhydryl reactive maleimide group bridged with PEG arm. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility that is transferred to the crosslinked molecules , thus reducing aggregation of labeled proteins in solution. The PEG spacer arm also gives the maleimide NHS a long and flexible structure to minimize steric hindrance for its reaction to other molecues. Compared to other maleimide NHS ester, SMCC has higher stability in aqueous solution because of its cyclohexane bridge. NHS esters react with primary amines at pH 7-9 while the maleimide group reacts with available thiol or sulfhydryl at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties:

Appearance: Off-white/brownish solid or semi-solid;
Reactivity: Reactive to sulfhydryl and amine groups;
Solubility: Soluble in DMF or DMSO;

Storage Conditions:

Store at -20 ⁰C, desiccated. Avoid frequent thaw and freeze.

SMCC-PEG12-NHS Cat. No. M2-P12S-1 5 mg修饰性聚乙二醇

发表于2024年1月23日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

SMCC-PEG12-NHS

Cat. No.	M2-P12S-1
Specification
Unit Size	5 mg
Price	$385.00

Description:

Physical Properties:

Appearance: Off-white/brownish solid or semi-solid;
Reactivity: Reactive to sulfhydryl and amine groups;
Solubility: Soluble in DMF or DMSO;

Storage Conditions:

Store at -20 ⁰C, desiccated. Avoid frequent thaw and freeze.

SMCC-PEG23-NHS Cat. No. M2-P23S-1 5 mg修饰性聚乙二醇

发表于2024年1月22日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

SMCC-PEG23-NHS

Cat. No.	M2-P23S-1
Specification
Unit Size	5 mg
Price	$385.00

Description:

Physical Properties:

Appearance: Off-white/brownish solid or semi-solid;
Reactivity: Reactive to sulfhydryl and amine groups;
Solubility: Soluble in DMF or DMSO;

Storage Conditions:

Store at -20 ⁰C, desiccated. Avoid frequent thaw and freeze.

SMCC-PEG45-NHS Cat. No. M2-P45S-1 5 mg修饰性聚乙二醇

发表于2024年1月22日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

SMCC-PEG45-NHS

Cat. No.	M2-P45S-1
Specification
Unit Size	5 mg
Price	$385.00

Description:

Physical Properties:

Appearance: Off-white/brownish solid or semi-solid;
Reactivity: Reactive to sulfhydryl and amine groups;
Solubility: Soluble in DMF or DMSO;

Storage Conditions:

Store at -20 ⁰C, desiccated. Avoid frequent thaw and freeze.

SMCC-PEG4-NH2 Cat. No. M2-P4A-1 5 mg修饰性聚乙二醇

发表于2024年1月14日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

SMCC-PEG4-NH2

Cat. No.	M2-P4A-1
Specification
Unit Size	5 mg
Price	$385.00

Description:

Nanocs SnapLink^TM pegylated succinimidyl cyclohexane Maleimide (SMCC) amine is a heterobifunctional crosslinker that can react with sulfhydryl and amine reactive groups, such as NHS ester. This crosslinker contains a sulfhydryl reactive maleimide group and a primary amine group bridged with PEG arm. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility that is transferred to the crosslinked molecules , thus reducing aggregation of labeled proteins in solution. The PEG spacer arm also gives the cyclohexane maleimide PEG amine a long and flexible structure to minimize steric hindrance for its reaction to other molecues. Compared to other maleimide NHS ester, SMCC has higher stability in aqueous solution because of its cyclohexane bridge. Maleimide group reacts with available thiol or sulfhydryl at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties:

Appearance: Off-white/white solid or semi-solid;
Reactivity: Reactive to thiols and activitated carboxylic groups.
Soluble in DMF or DMSO;

Storage Conditions:

Store at -20 ⁰C, desiccate. Avoid frequent thaw and freeze.

SMCC-PEG12-NH2 Cat. No. M2-P12A-1 5 mg修饰性聚乙二醇

发表于2024年1月13日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

SMCC-PEG12-NH2

Cat. No.	M2-P12A-1
Specification
Unit Size	5 mg
Price	$385.00

Description:

Physical Properties:

Appearance: Off-white/white solid or semi-solid;
Reactivity: Reactive to thiols and activitated carboxylic groups.
Soluble in DMF or DMSO;

Storage Conditions:

Store at -20 ⁰C, desiccate. Avoid frequent thaw and freeze.

SMCC-PEG23-NH2 Cat. No. M2-P23A-1 5 mg修饰性聚乙二醇

发表于2024年1月13日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

SMCC-PEG23-NH2

Cat. No.	M2-P23A-1
Specification
Unit Size	5 mg
Price	$385.00

Description:

Physical Properties:

Appearance: Off-white/white solid or semi-solid;
Reactivity: Reactive to thiols and activitated carboxylic groups.
Soluble in DMF or DMSO;

Storage Conditions:

Store at -20 ⁰C, desiccate. Avoid frequent thaw and freeze.

whatman (沃特曼)

英国沃特曼 Millipore PALL中国代理商金畔官网

标签归档：smcc

LC-SMCC (succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxy-(6-amidocaproate)) Cat. No. SMCC-LC-1 MW 444.78 100 mg修饰性聚乙二醇

LC-SMCC (succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxy-(6-amidocaproate))

Rha-PEG3-SMCC

Rha-PEG3-SMCC

Rha-PEG3-SMCC

SMCC-DM1(Synonyms: DM1-SMCC)

Sulfo-SMCC sodium

DM4-SMCC

Lys-SMCC-DM1(Synonyms: Lys-Nε-MCC-DM1)

SMCC/Maleimidocyclohexane NHS Cat. No. SMC01 MW 334.33 25 mg修饰性聚乙二醇

SMCC/Maleimidocyclohexane NHS

生物活性分子抑制剂SMCC

生物活性分子抑制剂SMCC

trans-Sulfo-SMCC

MMAE-SMCC

SMCC-PEG4-NHS Cat. No. M2-P4S-1 5 mg修饰性聚乙二醇

SMCC-PEG4-NHS

SMCC-PEG12-NHS Cat. No. M2-P12S-1 5 mg修饰性聚乙二醇

SMCC-PEG12-NHS

SMCC-PEG23-NHS Cat. No. M2-P23S-1 5 mg修饰性聚乙二醇

SMCC-PEG23-NHS

SMCC-PEG45-NHS Cat. No. M2-P45S-1 5 mg修饰性聚乙二醇

SMCC-PEG45-NHS

SMCC-PEG4-NH2 Cat. No. M2-P4A-1 5 mg修饰性聚乙二醇

SMCC-PEG4-NH2

SMCC-PEG12-NH2 Cat. No. M2-P12A-1 5 mg修饰性聚乙二醇

SMCC-PEG12-NH2

SMCC-PEG23-NH2 Cat. No. M2-P23A-1 5 mg修饰性聚乙二醇

SMCC-PEG23-NH2