标签归档：tert

20-(tert-Butoxy)-20-oxoicosanoic acid

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20-(tert-Butoxy)-20-oxoicosanoic acid 

20-(tert-Butoxy)-20-oxoicosanoic acid 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。20-(tert-Butoxy)-20-oxoicosanoic acid 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。

20-(tert-Butoxy)-20-oxoicosanoic acid

20-(tert-Butoxy)-20-oxoicosanoic acid Chemical Structure

CAS No. : 683239-16-9

规格 价格 是否有货 数量
100 mg ￥500 In-stock
250 mg ￥900 In-stock
500 mg ￥1400 In-stock
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5 g   询价  

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生物活性

20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 20-(tert-Butoxy)-20-oxoicosanoic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs

IC50 & Target

Non-cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

398.62

Formula

C24H46O4
CAS 号

683239-16-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

    [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

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20-(tert-Butoxy)-20-oxoicosanoic acid

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

20-(tert-Butoxy)-20-oxoicosanoic acid 

20-(tert-Butoxy)-20-oxoicosanoic acid 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。20-(tert-Butoxy)-20-oxoicosanoic acid 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。

20-(tert-Butoxy)-20-oxoicosanoic acid

20-(tert-Butoxy)-20-oxoicosanoic acid Chemical Structure

CAS No. : 683239-16-9

规格 价格 是否有货 数量
100 mg ￥500 In-stock
250 mg ￥900 In-stock
500 mg ￥1400 In-stock
1 g   询价  
5 g   询价  

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生物活性

20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 20-(tert-Butoxy)-20-oxoicosanoic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs

IC50 & Target

Non-cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

398.62

Formula

C24H46O4
CAS 号

683239-16-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

    [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

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20-(tert-Butoxy)-20-oxoicosanoic acid

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

20-(tert-Butoxy)-20-oxoicosanoic acid 

20-(tert-Butoxy)-20-oxoicosanoic acid 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。20-(tert-Butoxy)-20-oxoicosanoic acid 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。

20-(tert-Butoxy)-20-oxoicosanoic acid

20-(tert-Butoxy)-20-oxoicosanoic acid Chemical Structure

CAS No. : 683239-16-9

规格 价格 是否有货 数量
100 mg ￥500 In-stock
250 mg ￥900 In-stock
500 mg ￥1400 In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

生物活性

20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 20-(tert-Butoxy)-20-oxoicosanoic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs

IC50 & Target

Non-cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

398.62

Formula

C24H46O4
CAS 号

683239-16-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

    [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

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27-O-(tert-Butyldimethylsilyl)withaferin A

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

27-O-(tert-Butyldimethylsilyl)withaferin A 

27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a) 是一种天然的茄内酯，是一种细胞凋亡 (apoptosis) 诱导剂。27-O-(tert-Butyldimethylsilyl)withaferin A 对 HeLa、A-549 和 MCF-7 人类癌细胞系以及正常 Vero 细胞具有抗增殖活性。

27-O-(tert-Butyldimethylsilyl)withaferin A

27-O-(tert-Butyldimethylsilyl)withaferin A Chemical Structure

CAS No. : 1392820-18-6

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生物活性

27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an apoptosis inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells[1].

体外研究
(In Vitro)

27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a; 32 μM; 4-8 hours) inhibits caspase-3 activity in HeLa cells[1].
27-O-(tert-Butyldimethylsilyl)withaferin A (48 hours) shows antiproliferative activity against HeLa, A-549, MCF-7, and Vero cells with IC50 values of 0.9 μM, 1.5 μM, 0.7 μM, and 0.7 μM, respectively[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

584.86

Formula

C34H52O6Si
CAS 号

1392820-18-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Gabriel G Llanos, et al. Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells. Eur J Med Chem. 2012 Aug;54:499-511.

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TBHQ(Synonyms: 特丁基对苯二酚; tert-Butylhydroquinone)

发表于由

TBHQ (Synonyms: 特丁基对苯二酚; tert-Butylhydroquinone) 纯度: 99.76%

TBHQ (tert-Butylhydroquinone) 是一种广泛使用的 Nrf2 激活剂，通过激活 Nrf2 来免受 Doxorubicin (DOX)-诱导的心脏毒性。TBHQ (tert-Butylhydroquinone) 也是一种 ERK 激活剂，逆转 Dehydrocorydaline (DHC) 对黑素瘤细胞增殖的抑制作用。

TBHQ(Synonyms: 特丁基对苯二酚; tert-Butylhydroquinone)

TBHQ Chemical Structure

CAS No. : 1948-33-0

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥500 In-stock
500 mg ￥400 In-stock
1 g ￥500 In-stock
5 g   询价  
10 g   询价  

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TBHQ 相关产品

•相关化合物库:

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生物活性

TBHQ (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation of Nrf2[1]. TBHQ (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydrocorydaline (DHC)-induced cell proliferation inhibitionin melanoma[2].

IC50 & Target[1][2]

ERK

 

Nrf2

 

Autophagy

 

体外研究
(In Vitro)

TBHQ (t-butylhydroquinone; tBHQ; 0-100 μM; 48 hours; H9c2 cells) alone does not affect H9c2 cells viability. Pre-incubation of the H9c2 cells with various concentrations of tBHQ for 24 hours enhances cell viability which is decreased due to exposure to ethanol in a dose-dependent manner. Treatment with tBHQ markedly enhances the viability of H9c2 cardiomyocytes exposed to ethanol[3].
TBHQ (5 μM; 15 min; H9c2 cells) treatment significantly reduces the amount of apoptotic cells exposed to ethanol[3].
TBHQ (5 μM; H9c2 cells) pre-treatment markedly inhibites the ethanol-induced increase in caspase-3 and Bax expression, and enhances Bcl-2 expression[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: H9c2 cells
Concentration: 0 µM, 0.625 µM, 1.25 µM, 2.5 µM, 5 µM, 10 µM, 20 µM, 50 µM and 100 µM
Incubation Time: 48 hours
Result: Enhanced the viability of H9c2 cardiomyocytes exposed to ethanol.

Apoptosis Analysis[3]

Cell Line: H9c2 cells
Concentration: 5 μM
Incubation Time:
Result: Lowered the amount of apoptotic cells exposed to ethanol.

Western Blot Analysis[3]

Cell Line: H9c2 cells
Concentration: 5 μM
Incubation Time:
Result: Inhibited the ethanol-induced increase in caspase-3 and Bax expression, and enhanced Bcl-2 expression.

体内研究
(In Vivo)

TBHQ treatment (50 mg/kg; Intraperitoneal injection; three injections at intervals of 8 h that began 1-h post ICH; CD-1 mice) augments the DNA-Binding activity of Nrf2, attenuates oxidative brain damage and acute neurological deficits afterintracerebral hemorrhage (ICH), attenuates microglial activation with concomitant reduction in the release of proinflammatory cytokine interleukin-1β (IL-1β). TBHQ has the efficacy of post-injury administration in attenuating acute neurological injury after ICH[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD-1 mice (8-10 weeks old)[4]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection; three injections at intervals of 8 hours that began 1h post ICH.
Result: The treatment augmented the DNA-binding activity of Nrf2, attenuated brain oxidative damage, attenuated the microglial activation and the expression of IL-1β.

分子量

166.22

Formula

C10H14O2
CAS 号

1948-33-0
中文名称

特丁基对苯二酚；叔丁基对苯二酚
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 56.66 mg/mL (340.87 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 6.0161 mL 30.0806 mL 60.1612 mL
5 mM 1.2032 mL 6.0161 mL 12.0322 mL
10 mM 0.6016 mL 3.0081 mL 6.0161 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 50% PEG300    50% saline

    Solubility: 20 mg/mL (120.32 mM); Clear solution; Need ultrasonic

  • 2.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (15.04 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 3.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (15.04 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 4.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (15.04 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Lin-Feng Wang, et al. Tert-butylhydroquinone ameliorates doxorubicin-induced cardiotoxicity by activating Nrf2 and inducing the expression of its target genes. Am J Transl Res. 2015; 7(10): 1724–1735.

    [2]. XIAOJING SHI, et al. Tert-butylhydroquinone attenuates the ethanol-induced apoptosis of and activates the Nrf2 antioxidant defense pathway in H9c2 cardiomyocytes.Int J Mol Med. 2016 Jul; 38(1): 123–130.

    [3]. Hu H, et al. Dehydrocorydaline inhibits cell proliferation, migration and invasion via suppressing MEK1/2-ERK1/2 cascade in melanoma.Onco Targets Ther. 2019 Jul 2;12:5163-5175.

    [4]. Sukumari-Ramesh S, et al. Post-Injury Administration of Tert-butylhydroquinone Attenuates Acute Neurological Injury AfterIntracerebral Hemorrhage in Mice.J Mol Neurosci. 2016 Apr;58(4):525-31.

tert-Butyl 11-aminoundecanoate

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

tert-Butyl 11-aminoundecanoate  纯度: ≥98.0%

tert-Butyl 11-aminoundecanoate (compound 6b) 是一种 PROTAC linker，属于 PEG 类。tert-Butyl 11-aminoundecanoate 可用于合成一系列 PROTAC 分子。PROTAC 分子含有两个通过 linker 连接的不同配体；一种是 E3 泛素连接酶配体，另一种是靶蛋白配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。

tert-Butyl 11-aminoundecanoate

tert-Butyl 11-aminoundecanoate Chemical Structure

CAS No. : 220851-29-6

规格 价格 是否有货 数量
100 mg ￥1500 In-stock
200 mg   询价  
500 mg   询价  

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生物活性

tert-Butyl 11-aminoundecanoate (compound 6b) is a PROTAC linker, which refers to the PEG composition. tert-Butyl 11-aminoundecanoate can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC50 & Target[1]

Alkyl/ether

 

分子量

257.41

Formula

C15H31NO2
CAS 号

220851-29-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera. Sci Rep. 2019 Dec 23;9(1):19654.

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Cas(20330-45-4), 4'-<WBR>TERT-<WBR>BUTYLACETANILIDE, ,4'-<WBR>TERT-<WBR>BUTYLACETANILIDE,

发表于由

4'-<WBR>TERT-<WBR>BUTYLACETANILIDE

有货

Cas(20330-45-4), 4&#039;-&lt;WBR&gt;TERT-&lt;WBR&gt;BUTYLACETANILIDE, ,4&#039;-&lt;WBR&gt;TERT-&lt;WBR&gt;BUTYLACETANILIDE,

CAS编号 20330-45-4 | 品牌：Jinpan
4′-TERT-BUTYLACETANILIDE

MSDS

质检证书(CoA)

相似产品

  • 分子量191.275
  • MDL号 T168378
  • PubChem编号 140672

货号 (SKU) 包装规格 是否现货 价格 数量
T168378-50mg 50mg 期货 Cas(20330-45-4), 4&#039;-&lt;WBR&gt;TERT-&lt;WBR&gt;BUTYLACETANILIDE, ,4&#039;-&lt;WBR&gt;TERT-&lt;WBR&gt;BUTYLACETANILIDE,  

基本信息

产品名称 4'-TERT-BUTYLACETANILIDE
英文名称 4′-TERT-BUTYLACETANILIDE

相关属性

CAS编号 20330-45-4
储存温度 室温保存
MDL号 T168378
分子量 191.275
品牌 Jinpan
PubChem CID 140672

Cas(18144-47-3), 对氨基苯甲酸叔丁酯, 4-Aminobenzoic Acid tert-Butyl Ester,tert-Butyl 4-aminobenzoate,

发表于由

对氨基苯甲酸叔丁酯

98%

有货

Cas(18144-47-3), 对氨基苯甲酸叔丁酯, 4-Aminobenzoic Acid tert-Butyl Ester,tert-Butyl 4-aminobenzoate,

CAS编号 18144-47-3 | 品牌：Jinpan
tert-Butyl 4-aminobenzoate

MSDS

质检证书(CoA)

相似产品

  • 分子式 C11H15NO2
  • 分子量193.24
  • Beilstein号 2803178
  • MDL号 MFCD00665790
  • PubChem编号 233272

货号 (SKU) 包装规格 是否现货 价格 数量
T102206-5g 5g 现货 Cas(18144-47-3), 对氨基苯甲酸叔丁酯, 4-Aminobenzoic Acid tert-Butyl Ester,tert-Butyl 4-aminobenzoate,  
T102206-25g 25G 现货 Cas(18144-47-3), 对氨基苯甲酸叔丁酯, 4-Aminobenzoic Acid tert-Butyl Ester,tert-Butyl 4-aminobenzoate,  
T102206-100g 100g 现货 Cas(18144-47-3), 对氨基苯甲酸叔丁酯, 4-Aminobenzoic Acid tert-Butyl Ester,tert-Butyl 4-aminobenzoate,  

基本信息

产品名称 对氨基苯甲酸叔丁酯
英文名称 tert-Butyl 4-aminobenzoate
别名 4-Aminobenzoic Acid tert-Butyl Ester
英文别名 4-Aminobenzoic Acid tert-Butyl Ester
规格或纯度 98%
运输条件 常规运输

相关属性

CAS编号 18144-47-3
敏感性 对二氧化碳敏感； 对空气敏感
熔点 108-110°C
储存温度 充氩
Reaxys-RN 2803178
MDL号 MFCD00665790
分子量 193.24
分子式 C11H15NO2
品牌 Jinpan
Smiles Nc1ccc(cc1)C(=O)OC(C)(C)C
PubChem CID 233272

Perindopril erbumine(Synonyms: 培哚普利叔丁胺; Perindopril tert-butylamine salt; S-9490 erbumine)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Perindopril erbumine (Synonyms: 培哚普利叔丁胺; Perindopril tert-butylamine salt; S-9490 erbumine) 纯度: 99.98%

Perindopril erbumine (Perindopril tert-butylamine salt) 是长效血管紧张素转换酶（ACE）抑制剂。

Perindopril erbumine(Synonyms: 培哚普利叔丁胺; Perindopril tert-butylamine salt; S-9490 erbumine)

Perindopril erbumine Chemical Structure

CAS No. : 107133-36-8

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥660 In-stock
100 mg ￥600 In-stock
500 mg ￥1800 In-stock
1 g   询价  
5 g   询价  

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Perindopril erbumine 相关产品

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生物活性

Perindopril erbumine (Perindopril tert-butylamine salt) is a potent ACE inhibitor of which is used to treat high blood pressure, heart failure or stable coronary artery disease. Target: ACE Perindopril is a long-acting ACE inhibitor. It is used to treat high blood pressure, heart failure or stable coronary artery disease in form of perindopril arginine (trade names include Coversyl, Coversum) or perindopril erbumine (trade name Aceon). According to the Australian government’s Pharmaceutical Benefits Scheme website, based on data provided to the Australian Department of Health and Aging by the manufacturer, perindopril arginine and perindopril erbumine are therapeutically equivalent and may be interchanged without differences in clinical effect. However the dose prescribed to achieve the same effect will differ due to different molecular weights for the two forms. Perindopril is one of the most prescribed inhibitors of angiotensin converting enzyme, has a large evidence base, which allows to use it in patients with hypertension, diabetes mellitus type 2, coronary heart disease and chronic heart failure. In this review, the author focused on the evidence of organoprotecting properties of perindopril that lie outside lowering blood pressure.

Clinical Trial

分子量

441.60

Formula

C23H43N3O5
CAS 号

107133-36-8
中文名称

培哚普利叔丁胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : ≥ 50 mg/mL (113.22 mM)

DMSO : 10 mg/mL (22.64 mM; Need ultrasonic)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2645 mL 11.3225 mL 22.6449 mL
5 mM 0.4529 mL 2.2645 mL 4.5290 mL
10 mM 0.2264 mL 1.1322 mL 2.2645 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： PBS

    Solubility: 110 mg/mL (249.09 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Vaclavik J, Perindopril in the treatment of hypertension and cardiovascular diseases: evolution continues with the orodispersible dosage form. Vnitr Lek. 2013 Apr;59(4):290-4.

    [2]. Napalkov DA. Therapy with perindopril: organoprotection, not just the antihypertensive effect. Kardiologiia. 2012;52(12):80-3.

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Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine 

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine 是一种可降解 (cleavable) 的 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine 也是一种 PROTAC linker，属于 PEG 和 Alkyl/ether 类，可用于合成 PROTAC 分子。

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine Chemical Structure

CAS No. : 175724-30-8

规格 价格 是否有货 数量
50 mg ￥500 In-stock
100 mg   询价  
200 mg   询价  

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生物活性

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG/Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

PEGs

 

Cleavable

 

Alkyl/ether

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

505.64

Formula

C25H47NO9
CAS 号

175724-30-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Kostiainen MA, et al. Optically degradable dendrons for temporary adhesion of proteins to DNA. Chemistry. 2010 Jun 18;16(23):6912-8.

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N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline 

N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。

N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline

N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline Chemical Structure

CAS No. : 147266-92-0

规格 价格 是否有货 数量
1 g ￥400 In-stock
5 g ￥560 In-stock
10 g   询价  
50 g   询价  

* Please select Quantity before adding items.

生物活性

N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

IC50 & Target

Non-cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

231.25

Formula

C10H17NO5
CAS 号

147266-92-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

    [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

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22-(tert-Butoxy)-22-oxodocosanoic acid

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

22-(tert-Butoxy)-22-oxodocosanoic acid 

22-(tert-Butoxy)-22-oxodocosanoic acid 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。22-(tert-Butoxy)-22-oxodocosanoic acid 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。

22-(tert-Butoxy)-22-oxodocosanoic acid

22-(tert-Butoxy)-22-oxodocosanoic acid Chemical Structure

CAS No. : 1642333-05-8

规格 价格 是否有货 数量
100 mg ￥500 In-stock
250 mg ￥1000 In-stock
500 mg   询价  
1 g   询价  

* Please select Quantity before adding items.

生物活性

22-(tert-Butoxy)-22-oxodocosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 22-(tert-Butoxy)-22-oxodocosanoic acid is also a alkyl chain-based PROTAC linker that can be used in t

IC50 & Target

Non-cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

426.67

Formula

C26H50O4
CAS 号

1642333-05-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

    [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

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3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid_143527-70-2

发表于由
3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

  【编号】：VIP(XL)80371

  【产品名称】：3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

  【规格】：5mg；98%

  【用途】：

　　3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid对照品

　　编号：VIP(XL)80371
　　英文：3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid
　　CAS号：143527-70-2
　　分子式：C17H23NO5
3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid_143527-70-2
　　规格：可定做：10mg；20mg；50mg；100mg
　　声明：此对照品、标准品由上海金畔生物科技有限公司提供网站查询购买服务
　　注：点击cas，或者搜索：名称、编号、cas均可查询产品信息