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多肽定制Tyrosine Protein Kinase JAK 2 编码

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名称 Tyrosine Protein Kinase JAK 2
编码
别名 Tyrosine Protein Kinase JAK 2
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） VLPQDKEPYPYKVKEPGE
序列（三字母缩写） Val-Leu-Pro-Gln-Asp-Lys-Glu-pTyr-pTyr-Lys-Val-Lys-Glu-Pro-Gly-Glu
基本描述
溶解度
分子量 2082.18
化学式 C88H137N20O31P
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Tyrosine Protein Kinase JAK 2 编码
Figures Tyrosine Protein Kinase JAK 2 编码
Reference
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多肽定制Ac-Tyrosine Kinase Peptide 3 amide, (phosphorylated) 编码

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名称 Ac-Tyrosine Kinase Peptide 3 amide, (phosphorylated)
编码
别名 Ac-Tyrosine Kinase Peptide 3 amide, (phosphorylated)
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） Ac-RRLIEDAEPYAARG-NH2
序列（三字母缩写） Ac-Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-pTyr-Ala-Ala-Arg-Gly-NH2
基本描述
溶解度
分子量 1640.75
化学式 C66H110N23O24P
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Ac-Tyrosine Kinase Peptide 3 amide, (phosphorylated) 编码
Figures Ac-Tyrosine Kinase Peptide 3 amide, (phosphorylated) 编码
Reference
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多肽定制Biotin-Tyrosine Kinase Peptide 1 amide 编码

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名称 Biotin-Tyrosine Kinase Peptide 1 amide
编码
别名 Biotin-Tyrosine Kinase Peptide 1 amide
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） Biotin-KVEKIGEGTYGVVYK-NH2
序列（三字母缩写） Biotin-Lys-Val-Glu-Lys-Ile-Gly-Glu-Gly-Thr-Tyr-Gly-Val-Val-Tyr-Lys-NH2
基本描述
溶解度
分子量 1895.27
化学式 C87H139N21O24S
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Biotin-Tyrosine Kinase Peptide 1 amide 编码
Figures Biotin-Tyrosine Kinase Peptide 1 amide 编码
Reference
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Tyrosine kinase inhibitor

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Tyrosine kinase inhibitor  纯度: 99.96%

Tyrosine kinase inhibitor 是一种有效的酪氨酸激酶抑制剂。

Tyrosine kinase inhibitor

Tyrosine kinase inhibitor Chemical Structure

CAS No. : 1021950-26-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥4130 In-stock
5 mg ￥3200 In-stock
10 mg ￥4300 In-stock
25 mg ￥5500 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Tyrosine kinase inhibitor 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Kinase Inhibitor Library
  • Protein Tyrosine Kinase Compound Library
  • Anti-Cancer Compound Library
  • Anti-Lung Cancer Compound Library
  • Angiogenesis Related Compound Library
  • Anti-Liver Cancer Compound Library
  • Anti-Colorectal Cancer Compound Library

生物活性

Tyrosine kinase inhibitor is a potent tyrosine kinase inhibitor.

体外研究
(In Vitro)

Tyrosine kinases are important mediators of the signaling cascade, determining key roles in diverse biological processes like growth, differentiation, metabolism and apoptosis in response to external and internal stimuli[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

586.61

Formula

C31H31FN6O5
CAS 号

1021950-26-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 46 mg/mL (78.42 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7047 mL 8.5236 mL 17.0471 mL
5 mM 0.3409 mL 1.7047 mL 3.4094 mL
10 mM 0.1705 mL 0.8524 mL 1.7047 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.26 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.26 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.26 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.26 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.26 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.26 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Paul MK, et al. Tyrosine kinase – Role and significance in Cancer. Int J Med Sci. 2004;1(2):101-115.

    [2]. Inoue T, et al. Two cases of gastrointestinal perforation after radiotherapy in patients receiving tyrosine kinase inhibitor for advanced renal cell carcinoma. World J Surg Oncol. 2012 Aug 20;10(1):167.

    [3]. Bowen JM, et al. Development of a rat model of oral small molecule receptor tyrosine kinase inhibitor-induced diarrhea. Cancer Biol Ther. 2012 Nov 1;13(13).

    [4]. Sun FK, et al. Multi-targeted tyrosine kinase inhibitor sunitinib: a novel strategy for sporadic malignant pheochromocytoma. Chin Med J (Engl). 2012 Jun;125(12):2231-4.

    [5]. Thamm DH. Tyrosine kinase inhibitor special issue. Vet Comp Oncol. 2012 Sep;10(3):161-2. doi: 10.1111/j.1476-5829.2012.00339.x.

    [6]. Eriksson A, et al. The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia. Blood Cancer J. 2012 Aug 3;2:e81. doi: 10.1038/bcj.2012.28.

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多肽定制Hexa-L-Tyrosine 编码 [6934-38-9]

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名称 Hexa-L-Tyrosine
编码 [6934-38-9]
别名 Hexa-L-Tyrosine
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） YYYYYY
序列（三字母缩写） H-Tyr-Tyr-Tyr-Tyr-Tyr-Tyr-OH (trifluoroacetate salt)
基本描述 An H-2b-restricted OVA class II epitope used in studying T-cell activation and allergic diseases.
溶解度
分子量 997.1
化学式 C54H56N6O13
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Hexa-L-Tyrosine 编码 [6934-38-9]
Figures Hexa-L-Tyrosine 编码 [6934-38-9]
Reference
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EGFR Protein Tyrosine Kinase Substrate

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

EGFR Protein Tyrosine Kinase Substrate 

EGFR Protein Tyrosine Kinase Substrate 是EGFR 酪氨酸激酶的底物。

EGFR Protein Tyrosine Kinase Substrate

EGFR Protein Tyrosine Kinase Substrate Chemical Structure

CAS No. : 945830-38-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

EGFR Protein Tyrosine Kinase Substrate is a EGFR protein tyrosine kinase substrate.

分子量

1076.16

Formula

C48H73N11O17
CAS 号

945830-38-6
Sequence

Ala-Asp-Glu-Tyr-Leu-Ile-Pro-Gln-Gln
Sequence Shortening

ADEYLIPQQ
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

EGFR Protein Tyrosine Kinase Substrate

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

EGFR Protein Tyrosine Kinase Substrate 

EGFR Protein Tyrosine Kinase Substrate 是EGFR 酪氨酸激酶的底物。

EGFR Protein Tyrosine Kinase Substrate

EGFR Protein Tyrosine Kinase Substrate Chemical Structure

CAS No. : 945830-38-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

EGFR Protein Tyrosine Kinase Substrate is a EGFR protein tyrosine kinase substrate.

分子量

1076.16

Formula

C48H73N11O17
CAS 号

945830-38-6
Sequence

Ala-Asp-Glu-Tyr-Leu-Ile-Pro-Gln-Gln
Sequence Shortening

ADEYLIPQQ
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

EGFR Protein Tyrosine Kinase Substrate

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

EGFR Protein Tyrosine Kinase Substrate 

EGFR Protein Tyrosine Kinase Substrate 是EGFR 酪氨酸激酶的底物。

EGFR Protein Tyrosine Kinase Substrate

EGFR Protein Tyrosine Kinase Substrate Chemical Structure

CAS No. : 945830-38-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

EGFR Protein Tyrosine Kinase Substrate is a EGFR protein tyrosine kinase substrate.

分子量

1076.16

Formula

C48H73N11O17
CAS 号

945830-38-6
Sequence

Ala-Asp-Glu-Tyr-Leu-Ile-Pro-Gln-Gln
Sequence Shortening

ADEYLIPQQ
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务