UU-T02

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

UU-T02

UU-T02 是一种新型强效的 β-Catenin/T-cell factor 蛋白互作的选择性小分子抑制剂 (β-catenin/Tcf PPI)，K_i 为 1.36 μM。UU-T02 抑制典型 Wnt 信号的传导和结直肠癌细胞的生长。

UU-T02 Chemical Structure

CAS No. : 1500080-17-0

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生物活性	UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) with a K_i of 1.36 μM^[1]. UU-T02 inhibits canonical Wnt signaling and the growth of colorectal cancer cells^[2].
IC₅₀ & Target	Ki: 1.36 μM (β-catenin/Tcf PPI)^[1]. IC50: 6.3 μM (β-catenin/Tcf4), 680 μM (β-catenin/E-cadherin) , 210 μM (β-catenin/APC-R3)^[2].
体外研究 (In Vitro)	UU-T02 displays K_i values of 1.4 μM and 1.3 μM for β-catenin/Tcf PPI in FP assay and in AlphaScreen assay, respectively^[2]. UU-T02 inhibits β-catenin/Tcf4, β-catenin/E-cadherin, β-catenin/APC-R3, with the IC₅₀ of 6.3, 680, 210 μM，respectively^[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	665.09
Formula	C₃₃H₃₃ClN₄O₉
CAS 号	1500080-17-0
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Huang Z, et al. Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt β-catenin/T-cell factor protein-protein interactions. ACS Chem Biol. 2014;9(1):193-201. [2]. Catrow JL, et al. Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety. J Med Chem. 2015;58(11):4678-4692.

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UU-T02

UU-T02 Chemical Structure

CAS No. : 1500080-17-0

* Please select Quantity before adding items.

生物活性	UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) with a K_i of 1.36 μM^[1]. UU-T02 inhibits canonical Wnt signaling and the growth of colorectal cancer cells^[2].
IC₅₀ & Target	Ki: 1.36 μM (β-catenin/Tcf PPI)^[1]. IC50: 6.3 μM (β-catenin/Tcf4), 680 μM (β-catenin/E-cadherin) , 210 μM (β-catenin/APC-R3)^[2].
体外研究 (In Vitro)	UU-T02 displays K_i values of 1.4 μM and 1.3 μM for β-catenin/Tcf PPI in FP assay and in AlphaScreen assay, respectively^[2]. UU-T02 inhibits β-catenin/Tcf4, β-catenin/E-cadherin, β-catenin/APC-R3, with the IC₅₀ of 6.3, 680, 210 μM，respectively^[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	665.09
Formula	C₃₃H₃₃ClN₄O₉
CAS 号	1500080-17-0
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Huang Z, et al. Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt β-catenin/T-cell factor protein-protein interactions. ACS Chem Biol. 2014;9(1):193-201. [2]. Catrow JL, et al. Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety. J Med Chem. 2015;58(11):4678-4692.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

UU-T02

UU-T02 Chemical Structure

CAS No. : 1500080-17-0

* Please select Quantity before adding items.

生物活性	UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) with a K_i of 1.36 μM^[1]. UU-T02 inhibits canonical Wnt signaling and the growth of colorectal cancer cells^[2].
IC₅₀ & Target	Ki: 1.36 μM (β-catenin/Tcf PPI)^[1]. IC50: 6.3 μM (β-catenin/Tcf4), 680 μM (β-catenin/E-cadherin) , 210 μM (β-catenin/APC-R3)^[2].
体外研究 (In Vitro)	UU-T02 displays K_i values of 1.4 μM and 1.3 μM for β-catenin/Tcf PPI in FP assay and in AlphaScreen assay, respectively^[2]. UU-T02 inhibits β-catenin/Tcf4, β-catenin/E-cadherin, β-catenin/APC-R3, with the IC₅₀ of 6.3, 680, 210 μM，respectively^[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	665.09
Formula	C₃₃H₃₃ClN₄O₉
CAS 号	1500080-17-0
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Huang Z, et al. Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt β-catenin/T-cell factor protein-protein interactions. ACS Chem Biol. 2014;9(1):193-201. [2]. Catrow JL, et al. Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety. J Med Chem. 2015;58(11):4678-4692.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

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