CU-3 is the racemate of (5Z,2E)-CU-3. (5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].
分子量
392.47
Formula
C16H12N2O4S3
CAS 号
861123-84-4
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Liu K, et al. A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J Lipid Res. 2016 Mar;57(3):368-79.
(5Z,2E)-CU-3 是一种有效的选择性抗 DGKα 同工酶抑制剂，IC50 值为 0.6 μM，竞争性抑制 DGKα 对 ATP 的亲和力，Km 值为 0.48 mM。(5Z,2E)-CU-3 靶向 DGKα 催化区域，但不靶向调节区域。(5Z,2E)-CU-3 具有抗肿瘤和免疫原性作用，增强癌细胞的凋亡和 T 细胞的活化。
(5Z,2E)-CU-3 Chemical Structure
CAS No. : 1815598-71-0
规格
价格
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数量
Free Sample (0.1-0.5 mg)
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10 mM * 1 mL in DMSO
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5 mg
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500 mg
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(5Z,2E)-CU-3 相关产品
•相关化合物库:
Bioactive Compound Library Plus
Apoptosis Compound Library
Anti-Cancer Compound Library
生物活性
(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].
IC50 & Target
IC50: 0.6 μM (DGKα)[1]
分子量
392.47
Formula
C16H12N2O4S3
CAS 号
1815598-71-0
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder
-20°C
3 years
4°C
2 years
In solvent
-80°C
6 months
-20°C
1 month
溶解性数据
In Vitro:
DMSO : 20 mg/mL (50.96 mM; ultrasonic and warming and heat to 60°C)
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
[1]. Liu K, et al. A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J Lipid Res. 2016 Mar;57(3):368-79.
N-3-oxo-tetradec-7Z-enoyl-L-homoserine lactone (3-oxo-C14:1-Δ7cis-(L)-HSL) is a single, positional (carbon-carbon double bond between C7 and C8 of the N-3-oxo-acyl side chain), geometric (cis, or Z geometry), and stereoisomer (L, or S absolute stereochemistry at the 3-position of the homoserine lactone ring) of what may be generally referred to as a 3-oxo-C14:1-HSL. 3-oxo-C14:1-Δ7cis-(L)-HSL is a bacterial quorum sensing compound that possesses antimicrobial activity, the ability to inhibit biofilm formation, and exhibits immune suppressive activity. This compound is structurally related to other 3-oxo-monounsaturated (N-acylated homoserine lactones) AHLs such as 3-oxo-C16:1-Δ11cis-(L)-HSL.
10Z-Nonadecenoic acid is a kind of long-chain fatty acid with anti-tumor activity.
IC50 & Target
Human Endogenous Metabolite
体外研究 (In Vitro)
10Z-Nonadecenoic acid is a kind of long-chain fatty acid with anti-tumor activity[1]. 10Z-Nonadecenoic acid could also inhibit p53 activity[2].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
296.49
Formula
C19H36O2
CAS 号
73033-09-7
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Solution, -20°C, 2 years
参考文献
[1]. Fukuzawa M1, et al. Possible involvement of long chain fatty acids in the spores of Ganoderma lucidum (Reishi Houshi) to its anti-tumor activity. Biol Pharm Bull. 2008 Oct;31(10):1933-7.
[2]. Iijima H, et al. The inhibitory action of long-chain fatty acids on the DNA binding activity of p53. Lipids. 2006 Jun;41(6):521-7.
