标签归档：zio

Indibulin(Synonyms: ZIO 301; D 24851)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Indibulin (Synonyms: ZIO 301; D 24851) 纯度: 99.33%

Indibulin (ZIO 301)，一种口服有效的微管蛋白合成抑制剂，具有良好的抗癌活和极小的神经毒性。Indibulin 降低了肌间神经张力，产生异常的纺锤体，激活有丝分裂检查点蛋白 Mad2 和 BubR1，并诱导有丝分裂停滞和细胞凋亡。

Indibulin(Synonyms: ZIO 301; D 24851)

Indibulin Chemical Structure

CAS No. : 204205-90-3

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1210 In-stock
5 mg ￥1100 In-stock
10 mg ￥1600 In-stock
50 mg ￥5800 In-stock
100 mg ￥10200 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Indibulin 相关产品

•相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Cell Cycle/DNA Damage Compound Library
  • Anti-Cancer Compound Library
  • Clinical Compound Library
  • Anti-Aging Compound Library
  • Drug Repurposing Compound Library
  • Cytoskeleton Compound Library
  • Orally Active Compound Library
  • Anti-Lung Cancer Compound Library

生物活性

Indibulin (ZIO 301), an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis[1].

IC50 & Target

Tubulin[1]
体外研究
(In Vitro)

Indibulin (300-2100 nM; 48 hours) inhibits the proliferation of MCF-7 cells with an IC50 of 150 nM[1].
Indibulin (300, 600 nM; 48 hours) blockes the cells in the G2/M phase indicating that indibulin blockes the progression of the cell cycle at mitosis[1].
Indibulin (150-600 nM; 24 hours) induces apoptosis in MCF-7 cells[1].
Indibulin (150-600 nM; 48 hours) with 300 and 600 nM generates cleaved fragments of PARP protein the treatment of MCF-7 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MCF-7 cells
Concentration: 300, 600, 900, 1200, 1500, 1800, 2100 nM
Incubation Time: 48 hours
Result: Inhibited the proliferation of MCF-7 cells with an IC50 of 150 nM.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 300, 600 nM
Incubation Time: 48 hours
Result: Blocked the cells in the G2/M phase of the cell cycle.

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 150, 300 and 600 nM
Incubation Time: 24 hours
Result: Induced apoptosis in MCF-7 cells.

Western Blot Analysis[1]

Cell Line: MCF-7 cells
Concentration: 150, 300 and 600 nM
Incubation Time: 48 hours
Result: Generated cleaved fragments of PARP protein in 300 and 600 nM.

Clinical Trial

分子量

389.83

Formula

C22H16ClN3O2
CAS 号

204205-90-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (128.26 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5652 mL 12.8261 mL 25.6522 mL
5 mM 0.5130 mL 2.5652 mL 5.1304 mL
10 mM 0.2565 mL 1.2826 mL 2.5652 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (5.34 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.08 mg/mL (5.34 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.34 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (5.34 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Kapoor S, et al. Indibulin dampens microtubule dynamics and produces synergistic antiproliferative effect with vinblastine in MCF-7 cells: Implications in cancer chemotherapy. Sci Rep. 2018 Aug 17;8(1):12363.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Darinaparsin(Synonyms: ZIO-101; S-Dimethylarsino-glutathione)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Darinaparsin (Synonyms: ZIO-101; S-Dimethylarsino-glutathione)

Darinaparsin (ZIO-101) 是一种有机砷，是一种线粒体靶向剂。Darinaparsin 可诱导癌细胞凋亡 (apoptosis)，并具有抗癌作用。

Darinaparsin(Synonyms: ZIO-101; S-Dimethylarsino-glutathione)

Darinaparsin Chemical Structure

CAS No. : 69819-86-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Darinaparsin (ZIO-101), an organic arsenical, is a mitochondrial-targeted agent. Darinaparsin induces apoptosis in ancer cells, and has anticancer effects[1].

体外研究
(In Vitro)

Darinaparsin is cytotoxic to prostate cancer cell lines as well as fresh prostate cancer cells at low micromolar concentrations, and importantly inhibits the termed tumor-initiating cells (TIC) subpopulations[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Darinaparsin inhibits growth of the castrate-resistant Du145 prostate tumor propagated as xenograft in mice and inhibits the tumor-initiating potential of prostate cancer cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

411.31

Formula

C12H22AsN3O6S
CAS 号

69819-86-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Nitu Bansal, et al. Darinaparsin inhibits prostate tumor-initiating cells and Du145 xenografts and is an inhibitor of hedgehog signaling. Mol Cancer Ther. 2015 Jan;14(1):23-30.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务