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Pomalidomide-amido-C1-Br
Pomalidomide-amido-C1-Br 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Pomalidomide 的 cereblon 配体和 1 个 linker。Pomalidomide-amido-C1-Br 可通过 PROTAC 技术合成 B-Raf 降解剂 PROTAC B-Raf degrader 1 (HY-111758)。PROTAC B-Raf degrader 1 具有抗肿瘤活性。
Pomalidomide-amido-C1-Br Chemical Structure
CAS No. : 2351106-38-0
| 规格 | 价格 | 是否有货 | |
|---|---|---|---|
| 5 mg | ￥3500 | 询问价格 & 货期 | |
| 50 mg | ￥9500 | 询问价格 & 货期 | |
| 100 mg | ￥13500 | 询问价格 & 货期 | |
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| 生物活性 |
Pomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-amido-C1-Br can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1 (HY-111758). PROTAC B-Raf degrader 1 has anti-cancer activity[1]. |
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| IC50 & Target[1] |
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| 体外研究 (In Vitro) |
Pomalidomide-amido-C1-Br (Compound 6) can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1 (Compound 2). PROTAC B-Raf degrader 1 can effectively kill cancer cells via inducing cells apoptosis. As a B-Raf degrader, PROTAC B-Raf degrader 1 can accelerate the degradation of B-Raf by recruiting ubiquitin-proteasome system, and further affects the expression of Mcl-1, a downstream protein of B-Raf[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
394.18 |
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| Formula |
C15H12BrN3O5 |
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| CAS 号 |
2351106-38-0 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
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| 参考文献 |
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