NCT-506

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NCT-506 

NCT-506 是一种口服生物可利用的醛脱氢酶 1A1 (ALDH1A1) 抑制剂，IC50 为 7 nM。

NCT-506

NCT-506 Chemical Structure

CAS No. : 2231098-99-8

规格 价格 是否有货 数量
5 mg ￥3700 In-stock
10 mg ￥6000 In-stock
25 mg ￥12000 In-stock
50 mg   询价  
100 mg   询价  

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NCT-506 相关产品

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生物活性

NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with an IC50 of 7 nM[1].

体外研究
(In Vitro)

NCT-506 inhibits ALDH1A1, hALDH1A3, hALDH2 with IC50s of 0.007±0.001, 16.4±3.99, and 21.5 μM, respectively[1].
NCT-506 (100, 10, 1, 0.1 μM, 6 days) decreases significantly cell viability with an EC50 of 45.6 μM in OV-90 cells. NCT-506 inhibits MIA PaCa-2, OV-90, and HT-29 cells with IC50s of 0.077±0.040, 0.161±0.038, and 0.048±0.022 μM in aldefluor cell-based assays, respectively[1].
NCT-506 is treated in combined with Paclitaxel, IC50s of 1202, 924, 870, 411, 102, and 31.8 nM with concentrations of NCT-506 at 0 (DMSO), 1, 3, 10, 20, 30 μM in SKOV-3-TR cells, respectively[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: OV-90 and SKOV-3-TR cells
Concentration: 100, 10, 1, 0.1 μM
Incubation Time: 6 days for OV-90 cells; 4 days for SKOV-3-TR cells
Result: Decreased significantly cell viability with an EC50 of 45.6 μM in OV-90 cells. Decreased cell viability in combined treatments (Paclitaxel concentration of 100 nM) with an EC50 of 11.2 μM in SKOV-3-TR cells.

分子量

478.54

Formula

C25H23FN4O3S
CAS 号

2231098-99-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Yang SM, et al. Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity. J Med Chem. 2018 Jun 14;61(11):4883-4903.

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