Haspin-IN-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Haspin-IN-1 

Haspin-IN-1 (compound 2a) 是一种 haspin 抑制剂，IC50 为 119 nM。Haspin-IN-1 还抑制 CLK1 和 DYRK1A，IC50 分别为 221 nM 和 916.3 nM。

Haspin-IN-1

Haspin-IN-1 Chemical Structure

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生物活性

Haspin-IN-1 (compound 2a) is a haspin inhibitor with an IC50 of 119 nM. Haspin-IN-1 also inbibits CLK1 and DYRK1A with IC50s of 221 nM and 916.3 nM, respectively[1].

IC50 & Target[1]

CLK1

221 nM (IC50)

DYRK1A

916.3 nM (IC50)

Haspin Kinase

119 nM (IC50)

分子量

272.28

Formula

C12H8N4O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wael Zeinyeh, et al. Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity. Eur J Med Chem. 2022 Jun 5;236:114369.

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