Steroid sulfatase-IN-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Steroid sulfatase-IN-1 

Steroid sulfatase-IN-1 是一种有效的且具有口服活性的 Steroid sulfatase 抑制剂，IC50 为 1.71 µM。Steroid sulfatase-IN-1 在体内发挥抗肿瘤作用 (TGI=51%)。Steroid sulfatase-IN-1 具有乳腺癌研究潜力。

Steroid sulfatase-IN-1

Steroid sulfatase-IN-1 Chemical Structure

CAS No. : 2403716-19-6

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生物活性

Steroid sulfatase-IN-1 is a potent and orally active Steroid sulfatase inhibitor with an IC50 of 1.71 µM. Steroid sulfatase-IN-1 shows antitumor activity (TGI=51%) in vivo. Steroid sulfatase-IN-1 has the potential for the research of breast cancer[1].

IC50 & Target

IC50: 1.71 µM (Steroid sulfatase)[1]
体内研究
(In Vivo)

Steroid sulfatase-IN-1 (compound 4 b) (50 mg/kg; p.o.) shows significant antitumor activity with the TGI value of 51%[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 67NR mouse[1]
Dosage: 50 mg/kg
Administration: P.o.
Result: Showed significant antitumor activity with the TGI value of 51%.

分子量

385.23

Formula

C14H10Cl2N4O3S
CAS 号

2403716-19-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Biernacki K, et al. Development of Sulfamoylated 4-(1-Phenyl-1H-1,2,3-triazol-4-yl)phenol Derivatives as Potent Steroid Sulfatase Inhibitors for Efficient Treatment of Breast Cancer. J Med Chem. 2022; 65(6):5044-5056.

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