API-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

API-1 

API-1 是一种有效的 Akt/PKB 抑制剂，与 PH 结构域结合并抑制 Akt 膜易位。API-1 有效降低 Akt 的磷酸化水平，IC50 为 ∼0.8 μM。API-1 对 PKB 具有选择性，不抑制 PKC 和 PKA 的激活。API-1 还通过与 TNF 相关的凋亡诱导配体 (TRAIL) 协同作用来诱导细胞凋亡 (apoptosis)。

API-1

API-1 Chemical Structure

CAS No. : 36707-00-3

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生物活性

API-1, a potent Akt/PKB inhibitor, binds to the PH domain and inhibits Akt membrane translocation. API-1 efficiently reduces the phosphorylation levels of Akt with an IC50 of ∼0.8 μM. API-1 is selective for PKB and does not inhibit the activation of PKC, and PKA. API-1 also induces apoptosis by synergizing with TNF-related apoptosis-inducing ligand (TRAIL)[1][2].

分子量

337.29

Formula

C13H15N5O6
CAS 号

36707-00-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Donghwa Kim, et al. A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation. J Biol Chem. 2016 Oct 21;291(43):22856.

    [2]. Donghwa Kim, et al. A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation. J Biol Chem. 2016 Oct 21;291(43):22856.

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