TNIK-IN-4

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

TNIK-IN-4 

TNIK-IN-4 是一种有效的 TNIK 抑制剂，IC50 为 0.61 μM。TNIK-IN-4 对典型的结直肠癌细胞系 HCT116 具有抑制活性。

TNIK-IN-4

TNIK-IN-4 Chemical Structure

CAS No. : 2754266-04-9

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生物活性

TNIK-IN-4 is a potent TNIK inhibitor with IC50 of 0.61 μM. TNIK-IN-4 has inhibitory activity against typical colorectal cancer cell line HCT116[1].

IC50 & Target

IC50: 0.61 μM (TNIK)[1]
体外研究
(In Vitro)

TNIK-IN-4 (compound 5a) (0.4-100 μM; 72 hours) has inhibitory activity against typical colorectal cancer cell line HCT116 with IC50 of 36.423 μM[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line: HCT116 cells[1]
Concentration: 0.4, 1.2, 3.7, 11.1, 33.3 and 100 μM
Incubation Time: 72 hours
Result: Showed inhibitory activity against typical colorectal cancer cell line HCT116 with IC50 of 36.423 μM.

分子量

365.36

Formula

C20H16FN3O3
CAS 号

2754266-04-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Luo X, Yang R, Li Y, Zhang L, Yang S, Li L. Discovery of benzo[d]oxazol-2(3H)-one derivatives as a new class of TNIK inhibitors for the treatment of colorectal cancer. Bioorg Med Chem Lett. 2022;67:128745.

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