上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。
Top/HDAC-IN-2
Top/HDAC-IN-2 (45b) 是一种 Top 和 HDAC 的双重抑制剂，具有强大的抗肿瘤活性并诱导细胞凋亡。
Top/HDAC-IN-2 Chemical Structure
| 规格 |
|
是否有货 |
|
| 100 mg |
|
询价 |
|
| 250 mg |
|
询价 |
|
| 500 mg |
|
询价 |
|
* Please select Quantity before adding items.
| 生物活性 |
Top/HDAC-IN-2 (45b), a Top and HDAC dual inhibitor, exhibits potent antitumor activities and induces apoptosis[1].
|
| IC50 & Target |
|
HDAC1
0.004 μM (IC50)
|
HDAC2
0.005 μM (IC50)
|
HDAC3
1.10 μM (IC50)
|
HDAC6
0.15 μM (IC50)
|
HDAC8
4.5 μM (IC50)
|
Top1
|
Topoisomerase II
|
|
体外研究
(In Vitro) |
Top/HDAC-IN-2 (45b) shows antitumor activities against the HCT116 (IC50 = 0.23 µM), MCF-7 and A549 cells[1].
Top/HDAC-IN-2 (45b) (0-5 µM, 24h) arrests the HCT116 cell cycle at the G2 phase in a concentration-dependent manner[1].
Top/HDAC-IN-2 (45b) (0-2.5 µM, 24h) induces the apoptosis in HCT116 cell line in a concentration-dependent manner[1].
Top/HDAC-IN-2 (45b) (0-5 μM, 24h) inhibits HDAC in living cells[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Cycle Analysis[1]
| Cell Line: |
HCT116 |
| Concentration: |
0.1, 2.5 and 5 μM |
| Incubation Time: |
24 h |
| Result: |
Arrested the HCT116 cell cycle at the G2 phase in a concentration-dependent manner. |
Apoptosis Analysis[1]
| Cell Line: |
HCT116 |
| Concentration: |
0.1, 0.5 and 2.5 μM |
| Incubation Time: |
24 h |
| Result: |
Effectively induced the apoptosis in HCT116 cell line in a concentration-dependent manner. |
Western Blot Analysis[1]
| Cell Line: |
HCT116 |
| Concentration: |
1 μM and 5 μM |
| Incubation Time: |
24 h |
| Result: |
Concentration-dependently increased the level of acetyl-H3 and acetyl-H4 in HCT116 cells. |
|
| 分子量 |
|
| Formula |
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere.
|
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis.
|
| 参考文献 |
-
[1]. Fugui Zhu, et al. Design, Synthesis, and Structure-Activity relationships of Evodiamine-Based topoisomerase (Top)/Histone deacetylase (HDAC) dual inhibitors. Bioorg Chem. 2022 May;122:105702.
|
所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务
