GSD-11

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

GSD-11 

GSD-11 是一种有效的选择性抗紧缩剂。GSD-11 抑制 PANC-1 细胞的迁移和集落形成。GSD-11 抑制 Akt/mTOR 信号通路。GSD-11 具有研究胰腺癌的潜力。

GSD-11

GSD-11 Chemical Structure

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生物活性

GSD-11 is a potent and selective anti-austerity agent. GSD-11 inhibits the cell migration and colony formation of PANC-1 cells. GSD-11 inhibits the Akt/mTOR signaling pathway. GSD-11 has the potential for the research of pancreatic cancer[1].

体外研究
(In Vitro)

GSD-11 (0,1, 10, 100, 1000 µM) shows potent cytotoxicity against PANC-1 cells with PC50 value of 0.72 µM in nutrient-deprived medium (NDM), and IC50 value of 3.5 µM in Dulbecco’s modified Eagle’s medium (DMEM)[1].
GSD-11 (10 µM, 24 h) induces morphological change in PANC-1 cells[1].
GSD-11 (3, 5 µM, 24 h) inhibits the migration of PANC-1 tumor cells[1].
GSD-11 (1, 3, 5 µM, 24 h) shows strong colony formation inhibitory effect in PANC-1 tumor cells[1].
GSD-11 (2.5, 5, 10 µM) inhibits the survival of PANC-1 cells through the inhibition of the Akt/mTOR pathway under NDM conditions[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: PANC-1 cells
Concentration: 0,1, 10, 100, 1000 µM
Incubation Time:
Result: Showed preferential cytotoxicity against PANC-1 cells with PC50 of 0.72 µM in nutrient-deprived medium (NDM), and IC50 value of 3.5 µM in Dulbecco’s modified Eagle’s medium (DMEM).

Western Blot Analysis[1]

Cell Line: PANC-1 cells
Concentration: 2.5, 5, 10 µM
Incubation Time:
Result: Inhibited the survival of PANC-1 cells through the inhibition of the Akt/mTOR pathway under NDM conditions.

分子量

300.44

Formula

C20H28O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kohyama A, et al. Structure-activity relationship and mechanistic study on guggulsterone derivatives; Discovery of new anti-pancreatic cancer candidate. Bioorg Med Chem. 2022; 54:116563.

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