上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
MNK1/2-IN-6
MNK1/2-IN-6 是一种有效的选择性的 MNK1/2 抑制剂,IC50s 分别为 2.3 nM 和 3.4 nM。 MNK1/2-IN-6 以浓度依赖性方式诱导细胞凋亡 apoptosis。
MNK1/2-IN-6 Chemical Structure
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生物活性 |
MNK1/2-IN-6 is a potent and selective MNK1/2 inhibitor with IC50s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner[1]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
MNK1/2-IN-6 (compound II-5) (72 h) shows antiproliferative activity with IC50s of 0.3896µM, 0.4092 µM for TMD-8, DOHH-2 cells, respectively[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[1]
Apoptosis Analysis[1]
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分子量 |
448.52 |
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Formula |
C27H24N6O |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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