CVT-11127(Synonyms: GS-456332)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CVT-11127 (Synonyms: GS-456332)

CVT-11127 是一种有效的 SCD 抑制剂。CVT-11127 诱导细胞凋亡 apoposis 并将细胞周期阻滞在 G1/S 期。 CVT-11127具有肺癌研究潜力。

CVT-11127(Synonyms: GS-456332)

CVT-11127 Chemical Structure

CAS No. : 1018674-83-3

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生物活性

CVT-11127 is a potent SCD inhibitor. CVT-11127 induces apoposis and arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer[1].

IC50 & Target

SCD[1]
体外研究
(In Vitro)

CVT-11127 (1 µM, 48 h) shows antiproliferation activity in H460 cells[1].
CVT-11127 (1 µM, 48 h) decreases the the population of cells in S-phase by 75%[1].
CVT-11127 (1 µM, 48 h) induces apoposis in H460 cells[1].
CVT-11127 (1, 2 µM) inhibitors the SCD (stearoylCoA desaturase) activity in H460 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: H460 cells
Concentration: 1 µM
Incubation Time: 48 h
Result: Showed antiproliferation activity.

Cell Cycle Analysis[1]

Cell Line: H460 cells
Concentration: 1 µM
Incubation Time: 48 h
Result: Decreased the the population of cells in S-phase by 75%.

Apoptosis Analysis[1]

Cell Line: H460 cells
Concentration: 1 µM
Incubation Time: 24 h
Result: Induced apoposis H460 cells.

分子量

512.39

Formula

C25H23Cl2N5O3
CAS 号

1018674-83-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hess D,et al. Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. PLoS One. 2010; 5(6):e11394.

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