Phortress(Synonyms: NSC 710305)

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Phortress (Synonyms: NSC 710305)

Phortress 是一种高亲和力的 AhR 配体,通过诱导 CYP1A1 的转录表现出抗肿瘤活性。

Phortress(Synonyms: NSC 710305)

Phortress Chemical Structure

CAS No. : 328087-38-3

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生物活性

Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1[1][2].

分子量

459.41

Formula

C20H25Cl2FN4OS

CAS 号

328087-38-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Bradshaw TD, et al. In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles. Br J Cancer. 2002 Apr 22;86(8):1348-54.

    [2]. Bradshaw TD, Westwell AD. The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate. Curr Med Chem. 2004 Apr;11(8):1009-21.

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