Anticancer agent 29

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Anticancer agent 29 

Anticancer agent 29 (Compd E/Z-6f) 是一种抗癌剂，对 CDK2、CDK1、CDK4 和 CDK6 的 IC50 值分别为 0.054 μM、0.127 μM、0.129 μM、0.396 μM。

Anticancer agent 29

Anticancer agent 29 Chemical Structure

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生物活性

Anticancer agent 29 (Compd E/Z-6f) is an anticancer agent, with IC50 values of 0.054 μM, 0.127 μM, 0.129 μM, 0.396 μM for CDK2, CDK1, CDK4 and CDK6, respectively[1].

IC50 & Target[1].

CDK2/cyclinE

0.054 μM (IC50)

CDK1/cyclinB1

0.127 μM (IC50)

CDK4

0.129 μM (IC50)

CDK6

0.396 μM (IC50)

分子量

363.81

Formula

C22H15ClFNO
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hend A A Abd El-Wahab, et al. New cell cycle checkpoint pathways regulators with 2-Oxo-indoline scaffold as potential anticancer agents: Design, synthesis, biological activities and in silico studies. Bioorg Chem. 2022 Jan 15;120:105622.

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