上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
AR antagonist 3
AR antagonist 3 是一种有效的选择性 androgen receptor (AR) 拮抗剂,IC50 为 0.47 µM。AR antagonist 3 呈剂量依赖性降低 FRET 信号 (IC50= 18.05 μM)。当瘤内给药时,AR antagonist 3 可有效抑制肿瘤生长。
AR antagonist 3 Chemical Structure
CAS No. : 349573-58-6
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生物活性 |
AR antagonist 3 is a potent and selective androgen receptor (AR) antagonist with an IC50 of 0.47 µM. AR antagonist 3 exhibits a dose-dependent decrease of the FRET signal (IC50= 18.05 μM). AR antagonist 3 shows effective inhibition on tumor growth when administered intratumorally[1]. |
IC50 & Target |
IC50: 0.47 µM (AR)[1] |
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体外研究 (In Vitro) |
AR antagonist 3 (compound T1-12) (0.01, 0.1, 1, 10, 100 µM) shows excellent AR antagonistic activity (eGFP IC50= 0.47 μM; PSA IC50= 1.42 μM)[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
Cell Proliferation Assay[1]
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体内研究 (In Vivo) |
AR antagonist 3 (intratumorally injected; 2.5 mg/kg; every week for 25 days) inhibits tumor growth and the final tumor growth inhibition is 65%[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
306.38 |
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Formula |
C15H18N2O3S |
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CAS 号 |
349573-58-6 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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