P-gp inhibitor 2

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

P-gp inhibitor 2 

P-gp inhibitor 2 是一种有效的 P-gp 抑制剂。P-gp Inhibitor 2 在过表达 P-gp 的人结肠直肠癌细胞 (SW600 Ad300) 中显示出阿霉素耐药的逆转作用(IC50=0.22 µM)。

P-gp inhibitor 2

P-gp inhibitor 2 Chemical Structure

CAS No. : 2408406-89-1

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生物活性

P-gp inhibitor 2 is a potent P-gp inhibitor. P-gp inhibitor 2 shows reverse Doxorubicin resistance (IC50=0.22 µM) in P-gp overexpressing human colorectal carcinoma cells (SW600 Ad300)[1].

体外研究
(In Vitro)

P-gp inhibitor 2 (compound 2) exhibits no cytotoxicity (IC50>30 µM) toward human carcinoma (SW600) cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

498.53

Formula

C29H26N2O6
CAS 号

2408406-89-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Dewa AA, et al. Neochrysosporazines: Precursor-Directed Biosynthesis Defines a Marine-Derived Fungal Natural Product P-Glycoprotein Inhibitory Pharmacophore. J Med Chem. 2022, 65(3):2610-2622.

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