PI3K-IN-29

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PI3K-IN-29 

PI3K-IN-29 是一种有效的 PI3K 抑制剂。PI3K-IN-29 对 U87MG、HeLa 和 HL60 细胞具有较好的抑制作用，IC50 值分别为 0.264、2.04 和 1.14 µM。PI3K-IN-29 通过抑制 PI3K 催化的 Akt 的磷酸化来抑制 PI3K/Akt 通路。

PI3K-IN-29

PI3K-IN-29 Chemical Structure

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生物活性

PI3K-IN-29 is a potent PI3K inhibitor. PI3K-IN-29 displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 µM, respectively. PI3K-IN-29 inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K[1].

体外研究
(In Vitro)

PI3K-IN-29 (compound 25) (72 h) displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 µM, respectively[1].
PI3K-IN-29 (U87MG cells; 1, 5 µM; 1 h) inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: U87MG, HeLa, HepG2, A549, HL60, MCF7 cells
Concentration:
Incubation Time: 72 h
Result: Displayed good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 µM, respectively.

Western Blot Analysis[1]

Cell Line: U87MG cells
Concentration: 1, 5 µM
Incubation Time: 1 h
Result: Inhibited PI3K/Akt pathway by inhibiting phosphorylation of Akt that was catalyzed by PI3K.

分子量

560.03

Formula

C27H22ClN7O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tian C, et al. Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity. Bioorg Med Chem Lett. 2021, 48:128271.

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