上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
PHGDH-IN-2
PHGDH-IN-2 是一种有效的 NAD+ 竞争性 PHGDH 抑制剂,其IC50 值为 5.2 µM。PHGDH-IN-2 抑制 MDA-MB-468 细胞中的丝氨酸合成途径。PHGDH-IN-2 抑制 PHGDH 依赖性癌细胞的生长。
PHGDH-IN-2 Chemical Structure
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生物活性 |
PHGDH-IN-2 is a potent and NAD+ competitive PHGDH inhibitor with an IC50 of 5.2 µM. PHGDH-IN-2 inhibits the serine synthetic pathway in MDA-MB-468 cells. PHGDH-IN-2 inhibits the growth of PHGDH-dependent cancer cells[1]. |
IC50 & Target |
PHGDH[1] |
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体外研究 (In Vitro) |
PHGDH-IN-2 (compound C25) (10, 30 µM) inhibits the serine synthetic pathway in MDA-MB-468 cells[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[1]
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分子量 |
420.48 |
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Formula |
C22H20N4O3S |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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