上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
PARP1/BRD4-IN-1
PARP1/BRD4-IN-1 是一种有效、且具有高选择性的 PARP1/BRD4 抑制剂,PARP1 与 BRD4 的 IC50分别为 49 nM 与 202 nM。PARP1/BRD4-IN-1 通过抑制 PARP1 和 BRD4 的表达与活性,协同抑制胰腺癌细胞的恶性生长。
PARP1/BRD4-IN-1 Chemical Structure
CAS No. : 2758117-74-5
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生物活性 |
PARP1/BRD4-IN-1 is a potent and high selective PARP1/BRD4 inhibitor (IC50s of 49 and 202 nM in PARP1 and BRD4, respectively). PARP1/BRD4-IN-1 represses the expression and activity of PARP1 and BRD4 to synergistically inhibit the malignant growth of pancreatic cancer cells[1]. |
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IC50 & Target |
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体外研究 (In Vitro) |
PARP1/BRD4-IN-1 (compound III-7) (0-2 μM; 3-7 days) has potent inhibition of the growth of cancer cell lines[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay
Western Blot Analysis
Cell Cycle Analysis
Apoptosis Analysis
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体内研究 (In Vivo) |
PARP1/BRD4-IN-1 (30mg/kg; intraperitoneal injection for 28 days) can significantly inhibit the tumor size and weight, and does not cause significant damage of the kidney, lung, spleen, liver and heart in mice[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
506.56 |
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Formula |
C29H26N6O3 |
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CAS 号 |
2758117-74-5 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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